Notice of Participation in the 27th Interphex Week Tokyo from July 9 (Wednesday) to July 11 (Friday), 2025

RTRT reduces the effort of sampling, detects OOS and OOT through real-time analysis, and implements corrective actions, thereby reducing risk, labor, and operational costs.

In the pharmaceutical industry, processes that are free of waste and continuous improvement are required. Efficient processes enable the provision of safe and high-quality pharmaceuticals when needed. By adopting real-time testing of pharmaceutical water, it is possible to streamline the manufacturing process while ensuring quality. At Central Science, real-time testing of TOC and conductivity using the Sievers TOC analyzer optimizes the monitoring of pharmaceutical water systems, achieving better process control, productivity improvement, and risk management for cGMP processes. **Features** - Reduces costs, resources, contamination, lab errors, and data delays associated with traditional lab analysis - Detects and addresses OOS and OOT in real-time - Continuous control and system validation - Setting of alert levels and action levels based on trend data In the PDF data, you can find technical materials related to TOC real-time testing and information on the "Online TOC Analyzer Sievers M500" and "Sievers M9 Lab Model for Pharmaceutical Water/Cleaning Validation." *For more details, please download the catalog or contact us directly.*

• Other water quality analysis
• Water quality testing
• Pharmaceutical water production equipment and facilities

Shall we make the bio-burden test 45 minutes?

The bio-burden test is one of the important quality control processes to ensure the safety, quality, and compliance of pharmaceuticals. The culture method requires microbial cultivation, which takes about a week to determine results. The bio-burden rapid analysis device Soleil, developed by Sievers, can detect fewer than 10 viable microorganisms in 100 mL with ultra-high purity in under 45 minutes. It has a strong correlation with the culture method, enhancing the safety of pharmaceuticals and the efficiency of the manufacturing process while minimizing risks. In 2023, the PIC/S GMP Annex 1 was implemented, and rapid methods have begun to be adopted as a means of contamination control. This will be useful for the validation of pharmaceutical water/cleaning/process samples/raw materials/final products.

• Analytical Equipment and Devices

Endotoxin measurement is semi-automated! It significantly reduces the test error rate!

The endotoxin measurement device Eclipse, developed by Sievers, aims to make endotoxin testing easy for anyone. Many users have experienced challenges with traditional endotoxin measurements, such as the time and effort required for pipetting operations and the occurrence of human errors. Eclipse has achieved semi-automation of endotoxin measurement by developing a dedicated microplate and microfluidic technology. For measuring 21 samples, pipetting operations are reduced to fewer than 30 times, and since the standard samples are pre-filled, the preparation time and effort for testing are significantly reduced. Additionally, the amount of lysate reagent used is reduced by 90% to just 1mL, contributing to the ecological protection of horseshoe crabs. The IQ/OQ can also be completed in just a few days, so you can rest assured.

• Testing Equipment and Devices

An online TOC analyzer that adopts the "gas permeable membrane conductivity measurement technique" in accordance with the Japanese Pharmacopoeia General Test Method <2.59 Organic Carbon Test Method>.

The online TOC analyzer Sievers M500 is the third generation of online TOC analyzers that has developed Sievers' long-standing reagent-free gas permeable membrane conductivity measurement technology. While inheriting the conventional "accuracy," "reproducibility," and "stability," it has achieved rapid measurement and enhanced data management functions. 【Unique technology compliant with the Japanese Pharmacopoeia】 - Complies with the Japanese Pharmacopoeia General Test Method <2.59 Organic Carbon Test> - Complies with various national pharmacopoeias (USP <643>, EP 2.2.44) - Measures by separating carbon dioxide: gas permeable membrane conductivity measurement method - Calibration using potassium hydrogen phthalate - Detects sodium dodecylbenzenesulfonate with a recovery rate of over 90% 【High performance & high functionality】 - Real-time measurement at 3-minute intervals - Flexible sampling functions - Abundant system protocols - Data integrity compliant with 21 CFR Part 11

• Analytical Equipment and Devices

Rapid / Easy / Accurate TOC Measurement

The Sievers M9 can accommodate a variety of applications due to its unique gas-permeable membrane conductivity measurement method and wide measurement range (0.03 ppb to 50 ppm). Features of the Sievers M9: - No carrier gas required - Stability in ultra-low concentration range - 12 months of calibration stability - Three models to choose from based on application (laboratory type/portable type/online type) - Compliance with data integrity requirements based on 21 CFR Part 11 (optional) - The sample conductivity measurement function allows simultaneous measurement of TOC and conductivity (USP<645> Stage 1) (optional) - An auto-sampler can automatically analyze up to 63 samples (40mL) (optional)

• Analytical Equipment and Devices

We will be exhibiting at the "Industrial Exchange Exhibition." (November 26 (Wed) - 28 (Fri), 2025) Period: November 26 (Wed) - 28 (Fri), 2025 Venue: Tokyo Big Sight (Tokyo International Exhibition Center) Tokyo Big Sight West Exhibition Hall, Booth No. K-59 Exhibited Items: AGV + hot air circulation dryer, utilization of thermal fluid simulation, introduction of our proprietary "Unique Heating Technology Cross Flow Fan" Others: At our exhibition booth, we will showcase a practical application of our proprietary "Unique Heating Technology Cross Flow Fan" and a visualization model of thermal fluid simulation.

Kowa Co., Ltd. will be exhibiting at 'Aquatech China 2025' held at the Shanghai New International Exhibition Center (SNIEC) in China. This exhibition is a major international event focused on processes, beverages, and wastewater in China and Southeast Asia. The increasing demand for clean water, the promotion of environmental protection, and the strong enforcement of new regulations create significant opportunities for international companies specializing in wastewater technology in China. We sincerely look forward to your visit.

Kowa Co., Ltd. will be exhibiting at the "InterAqua 2026 17th Comprehensive Water Solutions Exhibition" held at Tokyo Big Sight. This exhibition is one of the largest specialized water business exhibitions in Japan that supports sustainable corporate activities. We will be showcasing a special exhibition titled "Water Treatment Solutions for Industry," where you can see technologies and products related to solving water treatment challenges in factories and facilities, recovering and reusing water resources, environmental risk management, and energy-saving and cost-reduction measures. We sincerely look forward to your visit.

[Speaker] Representative Director of KKR Consulting Co., Ltd. Director and Tax Accountant Junya Yamada of Yamada Junya Tax Accountant Office Tax Accountant Mika Ikeda [Lecture Items] ● Explanation of recent renewable energy installation methods, along with an overview of subsidy systems and tax incentives ● Regarding subsidy systems, an explanation of local government subsidies, primarily in the Kanto region 【1】Latest Renewable Energy Schemes 【2】Explanation of Renewable Energy-related Subsidies 1. National Subsidies (1) Storage Parity Subsidy (2) Subsidies for Agricultural Land, Carports, etc. (3) Regional Resilience Subsidy (4) Subsidies for Warehousing Businesses (5) Subsidies for Accommodation Facilities (6) Perovskite Solar Cell Subsidy (7) Support Subsidy for the Introduction of Storage Batteries for Grid Use 2. Local Government Subsidies, Primarily in the Kanto Region Tokyo, Kanagawa Prefecture, Chiba Prefecture, Saitama Prefecture, Tochigi Prefecture, Ibaraki Prefecture, Gunma Prefecture, etc. 【3】Explanation of Tax Systems Related to Renewable Energy Generation Equipment and Storage Batteries 1. Immediate Depreciation under the Small and Medium-sized Enterprise Management Strengthening Tax System 2. Carbon Neutral Tax System (Applicable to Large Enterprises) 3. Reduction System under the Advanced Equipment Introduction Plan 4. Taxation when receiving subsidies 【4】Q&A / Business Card Exchange

[Speaker] Tetsushi Sudo, Manager, Business Transformation Unit, NTT Data Management Research Institute [Lecture Items] 1. Current Status of Quantum Technology Research 2. Japan's Quantum Strategy Shift: Focus on Quantum Networks 3. Keys to Standardization of Quantum Networks 4. Actions Towards Strategy Implementation 5. Challenges and Solutions for Realization 6. Q&A / Business Card Exchange