Notice of Participation in the 27th Interphex Week Tokyo from July 9 (Wednesday) to July 11 (Friday), 2025

RTRT reduces the effort of sampling, detects OOS and OOT through real-time analysis, and implements corrective actions, thereby reducing risk, labor, and operational costs.

In the pharmaceutical industry, processes that are free of waste and continuous improvement are required. Efficient processes enable the provision of safe and high-quality pharmaceuticals when needed. By adopting real-time testing of pharmaceutical water, it is possible to streamline the manufacturing process while ensuring quality. At Central Science, real-time testing of TOC and conductivity using the Sievers TOC analyzer optimizes the monitoring of pharmaceutical water systems, achieving better process control, productivity improvement, and risk management for cGMP processes. **Features** - Reduces costs, resources, contamination, lab errors, and data delays associated with traditional lab analysis - Detects and addresses OOS and OOT in real-time - Continuous control and system validation - Setting of alert levels and action levels based on trend data In the PDF data, you can find technical materials related to TOC real-time testing and information on the "Online TOC Analyzer Sievers M500" and "Sievers M9 Lab Model for Pharmaceutical Water/Cleaning Validation." *For more details, please download the catalog or contact us directly.*

• Other water quality analysis
• Water quality testing
• Pharmaceutical water production equipment and facilities

Shall we make the bio-burden test 45 minutes?

The bio-burden test is one of the important quality control processes to ensure the safety, quality, and compliance of pharmaceuticals. The culture method requires microbial cultivation, which takes about a week to determine results. The bio-burden rapid analysis device Soleil, developed by Sievers, can detect fewer than 10 viable microorganisms in 100 mL with ultra-high purity in under 45 minutes. It has a strong correlation with the culture method, enhancing the safety of pharmaceuticals and the efficiency of the manufacturing process while minimizing risks. In 2023, the PIC/S GMP Annex 1 was implemented, and rapid methods have begun to be adopted as a means of contamination control. This will be useful for the validation of pharmaceutical water/cleaning/process samples/raw materials/final products.

• Analytical Equipment and Devices

Endotoxin measurement is semi-automated! It significantly reduces the test error rate!

The endotoxin measurement device Eclipse, developed by Sievers, aims to make endotoxin testing easy for anyone. Many users have experienced challenges with traditional endotoxin measurements, such as the time and effort required for pipetting operations and the occurrence of human errors. Eclipse has achieved semi-automation of endotoxin measurement by developing a dedicated microplate and microfluidic technology. For measuring 21 samples, pipetting operations are reduced to fewer than 30 times, and since the standard samples are pre-filled, the preparation time and effort for testing are significantly reduced. Additionally, the amount of lysate reagent used is reduced by 90% to just 1mL, contributing to the ecological protection of horseshoe crabs. The IQ/OQ can also be completed in just a few days, so you can rest assured.

• Testing Equipment and Devices

An online TOC analyzer that adopts the "gas permeable membrane conductivity measurement technique" in accordance with the Japanese Pharmacopoeia General Test Method <2.59 Organic Carbon Test Method>.

The online TOC analyzer Sievers M500 is the third generation of online TOC analyzers that has developed Sievers' long-standing reagent-free gas permeable membrane conductivity measurement technology. While inheriting the conventional "accuracy," "reproducibility," and "stability," it has achieved rapid measurement and enhanced data management functions. 【Unique technology compliant with the Japanese Pharmacopoeia】 - Complies with the Japanese Pharmacopoeia General Test Method <2.59 Organic Carbon Test> - Complies with various national pharmacopoeias (USP <643>, EP 2.2.44) - Measures by separating carbon dioxide: gas permeable membrane conductivity measurement method - Calibration using potassium hydrogen phthalate - Detects sodium dodecylbenzenesulfonate with a recovery rate of over 90% 【High performance & high functionality】 - Real-time measurement at 3-minute intervals - Flexible sampling functions - Abundant system protocols - Data integrity compliant with 21 CFR Part 11

• Analytical Equipment and Devices

Rapid / Easy / Accurate TOC Measurement

The Sievers M9 can accommodate a variety of applications due to its unique gas-permeable membrane conductivity measurement method and wide measurement range (0.03 ppb to 50 ppm). Features of the Sievers M9: - No carrier gas required - Stability in ultra-low concentration range - 12 months of calibration stability - Three models to choose from based on application (laboratory type/portable type/online type) - Compliance with data integrity requirements based on 21 CFR Part 11 (optional) - The sample conductivity measurement function allows simultaneous measurement of TOC and conductivity (USP<645> Stage 1) (optional) - An auto-sampler can automatically analyze up to 63 samples (40mL) (optional)

• Analytical Equipment and Devices

Our company will exhibit at the "Reiwa 7th Year Fukushima Industrial Exchange Fair," held at Pulse Iizaka, as our first exhibition to kick off 2026. This fair aims to expand new business transactions and create business opportunities within the region, as well as to promote interaction and collaboration with universities and support organizations. ★ Participating Industry Sectors Machinery, Electronics, Metals / Medical, Welfare / Robotics, Aerospace / Food Processing Environment, Energy / Information, IT / Universities, Support Organizations / Regional Municipalities On the day of the event, we will showcase a variety of popular injection-molded products and resin-cutting processed items, so please feel free to stop by the IIDA booth. 【Iida Manufacturing Co., Ltd. Fukushima No. 2 Factory】 〒969-1204 21-2 Mizukami, Nukazawa, Motomiya City, Fukushima Prefecture TEL: 0243-64-2320 FAX: 0243-64-2571

The highly acclaimed program "Basic Course Series on Analog ICs" by Nisshinbo Micro Devices, which received over 300 applications last time, is back. This time, we will hold the very popular "Operational Amplifier Classroom - What is an Operational Amplifier?" We will introduce the basic functions of operational amplifiers. The difficulty level is beginner, so whether you are new to analog ICs or have some questions, we encourage you to participate! With the latest 2026 recorded lectures and live Q&A sessions with engineers, even busy engineers can learn efficiently. ● Target Participants New employees, young designers Those who want to relearn about analog ICs Those who are about to engage in circuit design, etc. ● Agenda 1. What is an Operational Amplifier - What is an operational amplifier - What is an ideal operational amplifier - Application circuits of operational amplifiers - Typical amplification circuits and gain 2. Structure of Operational Amplifiers 3. Classification of Operational Amplifiers - Dual power supply/single power supply/full swing input/output - High precision/high speed/broadband/high output/low noise/low consumption We look forward to your participation!

Extracting essential information, data analysis for prediction, cause analysis, reduction, and classification: A Practical Introduction ~Multivariate Analysis Specialized for the Manufacturing Industry: Basics and Implementation Procedures/Know-how for Analytical Practice~ [Includes Software Distribution and PC Exercises] -------------------------------------------------- https://www.science-t.com/seminar/B260522.html ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ We will inform you about upcoming technical seminars with discounted participation fees. If you would like to apply for each seminar with a discount, please contact ikuma.fukui@wmjplab.com. * The discount on participation fees is available to anyone. * However, we do not accept participation from technical consultants or instructors. * If you wish to have an in-house training session for the same seminar, please contact me directly. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

Method for Determining Inspection Standards, Standard Values, and Safety Factors According to the Severity of Market Complaints ~ Fundamentals and Applications of Loss Functions that Balance Quality and Economic Efficiency ~ 【Includes PC Exercises (Templates that can also be used for in-house issue discussions)】 ------------------------------------------------------------ https://www.thplan.com/seminar/114398/ ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ We will inform you about upcoming technical seminars with discounts on participation fees. If you would like to apply for each seminar with a discount on the participation fee, please contact ikuma.fukui@wmjplab.com. * The discount on the participation fee is available to anyone. * However, we do not accept participation from technical consultants or instructors. * If you wish to have the same seminar as an in-house training, please contact me directly. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

Introduction to Artificial Intelligence Application Development Led by Element Technologists Basics of Deep Neural Network Models and MT Systems, Minimization of Training Data, Development Implementation Procedures ~ Learning AI Application Know-How through "Automation of Development, Virtual Inspection, and Detection of Unknown Anomalies" ~ 【AI Construction Demo Included, Excel Materials on AI Construction and Calculation Methods Provided to Interested Parties】 ------------------------------------------------------------ https://johokiko.co.jp/seminar_chemical/AD260103.php ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ We will inform you about upcoming technical seminars with discounted participation fees. If you would like to apply for each seminar with a discount, please contact ikuma.fukui@wmjplab.com. * The discount on participation fees is available to anyone. * However, we do not accept applications from technical consultants or instructors. * If you wish to have an in-house training session for the same seminar, please contact me directly. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━