Tohoku Univ. Technology : Intestinal bacteria that reduce uremic substances : T22-046
Intestinal bacteria that reduce p-cresyl sulfate
Previous studies have shown that several uremic substances, which cause exacerbation of diabetic nephropathy, are produced by intestinal bacteria. On the other hand, identification of intestinal bacterial species involved in the production of uremic substances has been difficult due to confounding factors such as renal function. The inventors identified intestinal bacteria involved in the reduction of uremic substances by analyzing them without confounding factors of renal function. The present invention relates to an agent for inhibiting the production of uremic toxins and a functional food containing these bacteria. Sesamol has also been proposed as a functional ingredient for reducing uremic substances by Professor Abe et al., one of the present inventors. (Uremic substance reducing agent containing sesame lignan (ttechnoarch.co.jp)) It is expected that the bacteria of the present invention will not be used as a single agent but will be commercialized aiming at a synergistic effect by combining with the above functional ingredients.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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