Analysis of the mechanism of action of skin permeability and the effects of components on the skin.
■Recommended for those with the following development challenges: - Want to elucidate the mechanisms of action of cosmetic and pharmaceutical ingredients on the skin. - Want to evaluate the skin permeability of cosmetic and pharmaceutical ingredients and quantify their metabolites. - Want to quantify the temporal changes of IL-8 after drug administration. - Want to conduct experiments under conditions that impose difficult stimuli or burdens on humans. ■Evaluation Features: - By using extremely fresh excised skin, it is possible to analyze the effects of test substances on the skin and their mechanisms in a state almost identical to human skin (such as stratum corneum barrier function). - In addition to measuring the amount of permeation of ingredients, it is also possible to quantify substances generated in the skin, such as metabolites and inflammatory factors. - It is possible to apply electrical or light stimuli, as well as create conditions of irritated skin, which are difficult to implement on humans. - Ideal for evaluating the usefulness of raw materials and formulations of cosmetics and pharmaceuticals, as well as physical stimulation from beauty devices. ■Test Overview: Extremely fresh human excised skin is used within a few hours after excision. A semi-permeable membrane is attached to the tip of a microprobe through which perfusion fluid circulates, and it is inserted into the dermis. The dialysis fluid after the use of the test substance is collected and quantified.
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Basic research on cosmetics and pharmaceuticals.
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There are many testing organizations, but have you ever been unsure about which evaluation organization to request, or found that you couldn't conduct tests in your desired evaluation system? Nikoderm Research achieves various evidence acquisition by partnering with testing organizations around the world. Our contracted areas include in vitro / ex vivo / in vivo evaluations related to skin, providing evidence data across a wide range of development and research stages, from raw materials of cosmetics and chemical products to finished products and beauty devices. Additionally, we are the exclusive distributor of EPISKIN in Japan. We also import and sell three-dimensional culture tissue models (SkinEthic series) used for evaluations and experiments. *For inquiries, please visit our website. https://www.nikoderm.com/?utm_source=ndr&utm_medium=ipros
