Hokkaido Univ. Technology : Bio-Catalytic Approach to Mesoscopic Particle Synthesis : HK24-007
Innovative method using hydrolytic action of enzymes
Mesoscopic particles, ranging from several tens to several hundred nm in size, have attracted attention in a wide range of fields as interesting materials where quantum size effects and bulk effects interact or synergize. Regarding manufacturing methods, top-down approaches such as physical grinding and bottom-up approaches such as chemical synthesis have been proposed. However, these methods face challenges related to yield, dispersibility, and cost, necessitating new solutions. In this study, the inventor has developed a novel manufacturing method to address these issues: the "Biocatalytic Nanoparticle Shaping method" (BNS method), which utilizes enzymes. The BNS method can be applied to fabricate various mesoscopic particles by combining enzyme-degradable materials with organic/inorganic materials. For example, semiconducting quantum dots (QDs), porphyrin molecules, bipyridine molecules, and nanographene were used as core units, resulting in nearly monodispersed mesoscopic particles with uniform sizes, obtained as stable aqueous dispersions.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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