Accelerating upstream bioprocessing with rapid processing times.
Is the time it takes to obtain analysis results a bottleneck in the analysis of cell culture media (CCM), clone selection, process development, and optimization? Waters' bioprocessing walk-up solution eliminates that time lag and accelerates your decision-making. Efficient upstream bioprocessing from cell line development (CLD) to upstream process development (USP) requires a high-sensitivity, robust high-throughput analytical platform. This system is an ideal choice for at-line process analytical technology (PAT) that can overcome cumbersome routine measurements of CPP and CQA, with the capability to integrate with bioreactors such as Sartorius Ambr 15 and Ambr 250, achieving the following: ■ Streamlining the workflow from sample pretreatment to data acquisition through data analysis using samples from the bioreactor ■ Generating quantitative analytical results that guide process development (for both CPP and CQA) ■ Enabling faster and more reliable decision-making through high-quality data from samples taken from the bioreactor
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The BioAccord system equipped with the Automation Portal is an LC-MS based PAT solution that features an automated workflow from sample to results, allowing for the rapid evaluation of both CPP and CQA from samples taken from bioreactors.
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Applications/Examples of results
- Analysis of nutrient components and metabolites in cell culture media - Automated analysis of product quality characteristics
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Waters Corporation, headquartered in Milford, Massachusetts, USA, has played a pioneering role as a specialized manufacturer of liquid chromatography since its establishment in 1958. Actively engaged in the development of new products and technologies, it has grown into an international group company that supplies not only high-performance liquid chromatography but also mass spectrometers (MS) and thermal analysis instruments. Waters Japan started operations in 1973 (Showa 48) as the Japanese base of Waters Corporation. Inheriting the corporate ethos of the U.S. headquarters, we have made "Customer Success" our mission and continue to provide innovative technologies and lab solutions.