Tohoku Univ. Technology : Aspergillus oryzae introduced with multi-copy genes : T24-084
Extremely high production level of target protein by fermentation (3 g/L)
In protein production using Aspergillus oryzae, the introduction of multi-copy genes encoding target proteins can be used as a means of improving productivity. However, if the DNA fragment to be introduced is tandemly inserted at one chromosomal locus and the repair through homologous recombination is repeated, the sequence may be excised, and the production cannot be increased as a result. Dr. Zhang and colleagues at the Graduate School of Agriculture, Tohoku University have developed a method to introduce DNA fragments into multiple loci of the chromosome of A. oryzae in a single transformation, and succeeded in obtaining a new A. oryzae in a short period of time. The A. oryzae of the present invention has been confirmed to have improved material productivity. Furthermore, by using a highly dispersible strain of mycelium as a host, it is expected to be low in viscosity when cultured in a fermenter, enabling continuous culture.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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