Tohoku Univ. Technology : A novel mitochondrial oxidative stress marker : T24-075
Enabling highly specific and accurate evaluation of oxidative stress in mitochondria
Oxidative stress is a phenomenon in which excessive reactive oxygen species are produced, increasing biological oxidative damage such as DNA and RNA mutations and protein denaturation, and is said to lead to various diseases and accelerated aging. More than 90% of reactive oxygen species in living organisms are generated in mitochondria, where oxygen respiration occurs, and mitochondria are known to be susceptible to oxidative damage. However, there is no mitochondria-specific oxidative stress marker until now. The present invention finds ms2A as an oxidative stress marker for mitochondrial tRNA for the first time, and provides a method for evaluating mitochondria-specific oxidative stress levels.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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