Detection of TOC and conductivity of alkaline cleaning agents using TOC measurement.
300_00296
[Test Report] Simultaneous Measurement of TOC and Conductivity of Alkaline Cleaners Using Sievers M Series TOC Analyzer
In the pharmaceutical industry, cleaning validation of manufacturing equipment is a crucial element of quality control. In particular, accurately detecting residues of alkaline cleaning agents is essential for ensuring product safety and quality. Here, we will introduce a method for simultaneously measuring the TOC and conductivity of alkaline cleaning agents using the Sievers M9 TOC analyzer. - Characteristics and Importance of Alkaline Cleaning Agents We selected CIP-100Ⓡ as the alkaline cleaning agent commonly used for cleaning manufacturing equipment during product changeovers in the pharmaceutical industry. Its composition includes potassium hydroxide (10-30%) and disodium EDTA (1-5%), which contribute to its cleaning effectiveness. In cleaning validation, it is important to confirm that no cleaning agent remains on the equipment after the final rinse.
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- Measurement Methods for TOC and Conductivity CIP-100 was diluted to four concentrations (0.001%, 0.01%, 0.025%, 0.05%) and measured using the Sievers M9 model. - Results and Discussion Both TOC and conductivity showed very good linearity. It was reliably detectable even at the lowest concentration (0.001%). - Summary The Sievers M9 TOC analyzer can simultaneously measure both TOC and conductivity, which is helpful for detecting detergent residues during the cleaning validation process. CIP-100 is a common alkaline detergent, and the Sievers M9 allows for easy detection of trace concentrations through simultaneous measurement of TOC and conductivity. Please refer to the test report for more details.
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Cleaning validation
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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.