Tohoku Univ. Technology ： The Treatment and Prevention of Inflammatory Bowel Disease : T23-033
Anti-inflammatory effect by xCT inhibition or Glutamine synthetase inhibition
The limited number of drugs available for the treatment of inflammatory bowel disease(IBD) and their severe side effects, including immunosuppression, have led to calls for research into drugs without side effects. The inventors focused on the role of xCT, a cystine/glutamate antiporter, in IBD. Their research suggests that xCT inhibitors or glutamine synthetase inhibitors may be therapeutic/preventive agents for inflammatory diseases. [RESULTS] ・Mice with intestinal epithelium-specific xCT deficiency showed anti-inflammatory effects on dextran sulfate sodium(DSS) colitis(Fig.1). ・Glutamine synthetase inhibitor (MSO：Methionine sulfoximine) showed anti-inflammatory effects on DSS colitis(Fig.2).
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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