Tohoku Univ. Technology : Multi-targeted Kinase Inhibitor containing Liphagal or analog thereof : T16-138
Siphonodictyal B induces apoptosis in cancer cells
The inventors found that Liphagal and its analog Siphonodictyal B inhibited multiple kinase activities in addition to PI3K. The inhibitors can be used as inhibitors of CDK7, CDK4, CDK6, PIM2, TSSK3, MST4, NEK6, MAP3K, MST3, DDR1, SPHK1, CaMK1, AurA, BRK, CaMK4 and PIM1 kinases. Studies using human colorectal cancer cells revealed that Siphonodictyal B induces expression of pro-apoptotic proteins by activation of the P38 MAPK pathway following an increase in intracellular reactive oxygen species, leading to apoptosis. In addition, Siphonodictyal B showed anti-tumor effects in a human colorectal cancer cell line tumor-transplanted mouse model.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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