Tohoku Univ. Technology ：Epileptogenic domain estimation program：T21-359
Real-time EZ determination from intermittent EEG!
Traditionally, a specialist determines the epileptogenic area (EZ) to be removed during epilepsy surgery by comprehensively judging the results of EEG, CT and MRI, SPECT and PET. Conventional methods are challenged by (1) low accuracy, (2) the length of the examination period (which requires at least one week), and (3) the high burden on the patient (two surgeries, the installation of an electroencephalograph and the removal of EZ). The present invention can estimate the seizure origin (SOZ) and EZ with high accuracy and speed without waiting for an epileptic seizure by analyzing the high-frequency electroencephalogram during the interictal period. Specifically, since EZ can be precisely determined in about 30 minutes after the installation of the electroencephalograph (electrode), it is theoretically possible to determine and remove EZ in a single operation, greatly reducing the patient's burden. It is expected that real-time EEG analysis software based on the present invention will be developed and implemented in EEG equipped with the software.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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