Measurement of nitrite in hypromellose [Ion Chromatography Technical Document]
Measurement of nitrite in hydroxypropyl methylcellulose by ion chromatography.
The presence of carcinogenic nitrosamines in pharmaceuticals poses a threat to patient safety. By controlling the concentration of nitrites in drugs and processes, the formation of nitrosamines can be prevented, making it essential to have a highly sensitive method for analyzing nitrites in pharmaceuticals and their raw materials. In many cases, dimethylamine is used in the synthesis of various drugs. Under acidic conditions, it reacts with nitrites to form nitrosamines. This also applies to the production of hydroxypropyl methylcellulose (HPMC), a common excipient. This technical document introduces the quantification of nitrites in hydroxypropyl methylcellulose using ion chromatography (IC) with direct UV/VIS detection.
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