Tohoku Univ. Technology : Strong promoter for marine invertebrates : T22-084
OsHV-1 promoter for gene delivery and a variety of applications in bivalve molluscs.
Understanding gene functions in marine invertebrates has been limited, largely due to the lack of suitable assay systems. The inventors discovered a strong viral promoter derived from a bivalve-infectious virus, ostreid herpesvirus-1 (OsHV-1). This promoter showed 24.7-fold and 16.1-fold higher activity than the cytomegalovirus immediate early (CMV IE) promoter and the endogenous EF1α promoter, the two most commonly used promoters in bivalves so far (Fig.1). GFP assays showed that the OsHV-1 promoter is active not only in scallop cells (Fig.2) but also in HEK293 cells (Fig.3) and zebrafish embryos.
- Company：Tohoku Techno Arch Co., Ltd.
- Price：Other
