ヒューマン・メタボローム・テクノロジーズ List of Products and Services

Our company offers a "Metabolome Contract Analysis Service," providing various analysis plans. We analyze the types and concentrations of numerous metabolites. We deliver test reports that include relative values or concentration calculations of detected substances, inter-group comparisons using detection data, principal component analysis, heat maps, and more. This service can broadly analyze organic acids, functional components, and has a proven track record in analyzing natural material components such as plant and food extracts, as well as in examining conditions for substance production. 【Features】 ■ High-sensitivity analysis using the measurement technique "CE-MS method" ■ Data from other companies or institutions can also be analyzed if it is metabolome data ■ Additional statistical analyses can be performed as an option ★ We are currently offering a free on-demand video explaining "Lipidome Analysis," which allows for comprehensive analysis of lipid-soluble metabolites. Please register for viewing using the link below. *For details about the service, please refer to the materials. Feel free to contact us with any inquiries.

• Contract Analysis

Our company offers a wide range of contract metabolome analysis services. The non-targeted high-sensitivity metabolome analysis service "ω Scan Advanced" comprehensively and sensitively analyzes both known metabolites (over 1,000 types) and unidentified peaks, including peaks with unknown substance names, for water-soluble and ionic metabolites. In addition to covering many primary metabolites such as sugar phosphates, amino acids, nucleic acids, organic acids, vitamins, short/medium-chain fatty acids, and dipeptides with high-sensitivity analysis through "Omega Scan," this plan also reports all peaks that can be analyzed with high-sensitivity CE-FTMS (non-targeted analysis), making it the most comprehensive plan available. This service is recommended for those who want to explore not only known metabolites but also new metabolites, conduct screenings to capture extensive metabolic changes, or search for unknown biomarkers. *For more details, please click on the related links below. Feel free to contact us as well.

• Public Testing/Laboratory

HMT has partnered with MiRXES, based in Singapore, to provide miRNA (microRNA) analysis services. The ID3EAL technology, utilizing MiRXES's patented technology, is an excellent miRNA measurement method with superior specificity, detection sensitivity, and reproducibility, supporting your research and development. One of our panel (kit) products, the 'Biofluid Panel,' is a profiling panel that carefully selects 176 target miRNAs based on our own research using over 20,000 serum, plasma, and urine samples from healthy individuals and patients with diseases. It is utilized for biomarker discovery in liquid biopsies. *For more details, please refer to the link below or feel free to contact us.*

• Public Testing/Laboratory

HMT has partnered with MiRXES, based in Singapore, to provide miRNA (microRNA) analysis services. The ID3EAL technology, which utilizes MiRXES's patented technology, is an excellent miRNA measurement method with superior specificity, detection sensitivity, and reproducibility, supporting your research and development. One of our panel (kit) products, the 'Cancer Panel,' is a profiling panel that collects 352 types of miRNAs related to cancer. The target miRNAs are carefully selected based on databases such as miRbase 22, HMDD v3.2, The Cancer Genome Atlas, as well as our own research and highly influential academic papers. *For more details, please refer to the link below or feel free to contact us.

• Public Testing/Laboratory

HMT has partnered with MiRXES, based in Singapore, to provide miRNA (microRNA) analysis services. The ID3EAL technology, which utilizes MiRXES's patented technology, is an excellent miRNA measurement method with superior specificity, detection sensitivity, and reproducibility, supporting your research and development. One of our contract analysis services, "Premium 700," is a contract analysis service that performs absolute quantification of 700 types of miRNA using ID3EAL technology. It is recommended for clinical trials and biomarker discovery. *For more details, please refer to the link below or feel free to contact us.*

• Public Testing/Laboratory

HMT has partnered with MiRXES, a company based in Singapore, to provide miRNA (microRNA) analysis services. The ID3EAL technology, which utilizes MiRXES's patented technology, offers an excellent method for miRNA measurement with high specificity, detection sensitivity, and reproducibility, supporting your research and development. One of our contract analysis services, the 'PanoramiR miRNA KNOWLEDGE PANEL,' is a contract analysis service that uses a profiling panel of 376 carefully selected miRNAs related to various diseases. The target miRNAs are selected based on databases such as miRbase 22, HMDD v3.2, The Cancer Genome Atlas, as well as our own research and influential academic papers. This service is recommended for basic research in biomarker discovery and disease mechanism analysis. *For more details, please refer to the link below or feel free to contact us.*

• Public Testing/Laboratory

Dual scan is a comprehensive analysis plan that covers over 1,300 metabolites, including more than 1,000 water-soluble and ionic metabolites, and over 300 fat-soluble and neutral metabolites. It encompasses a wide range of metabolites such as sugar phosphates, amino acids, nucleic acids, organic acids, vitamins, short/medium-chain fatty acids, dipeptides, as well as fatty acids, acylcarnitines, bile acids, and steroid derivatives, making it highly recommended for those who want to conduct metabolome analysis of a wide variety of substances. 【Main Applications】 ◎ Research on intestinal bacteria ◎ Food analysis ◎ Understanding metabolic changes in primary metabolism present in many biological species ◎ Exploring new networks between metabolites and pathways *For more details, please download the PDF document or feel free to contact us.

• Contract Analysis
• Public Testing/Laboratory

This is a service provided in collaboration between HMT and Lipidome Lab Co., Ltd., offering contract analysis of lipidomes. In addition to targeted analysis that accurately analyzes specific types of lipids contained in the substances listed below, we also offer non-targeted analysis that can analyze a wider range of lipids. This can be applied in a wide range of research areas related to lipids. - Basic research fields aimed at substrate/ligand exploration and molecular dynamics analysis - Medical fields aimed at elucidating disease mechanisms, diagnostic markers, and drug discovery - Food fields aimed at supplement development and quality evaluation - Beauty and cosmetics fields aimed at cosmetic development through skin ceramide evaluation - Others (such as sports science and biofuels)

• Contract Analysis
• Public Testing/Laboratory

Our company offers a "metabolome analysis service" centered around the innovative analytical technique "CE-MS." **What is metabolome analysis?** In living organisms, there are low molecular weight substances such as sugars, organic acids, and amino acids, in addition to nucleic acids (DNA) and proteins. Many of these substances are metabolites produced by the action of enzymes. The totality of metabolites contained within a living organism is referred to as the "metabolome" (a coined term from "metabolite" and "-ome"), and the method of comprehensively analyzing their types and concentrations is called "metabolome analysis" or "metabolomics." Therefore, in metabolomics, the key is the technology that allows for the simultaneous and comprehensive measurement of metabolite levels present in the sample. At HMT, we leverage the innovative measurement technique "CE-MS" while combining multiple measurement instruments to enable analyses tailored to our customers' objectives. *For more details, please refer to the PDF document or feel free to contact us.*

• Other analyses
• Analysis Services

"I don't know the differentiation points of our products..." "I want to find new selling points without conducting new development..." "The direction for future product development is unclear..." ...These challenges may be solved with "metabolome analysis." Our company is a leading provider of metabolome analysis, with nearly 5,000 testing achievements across various fields, primarily in food and pharmaceuticals, as well as materials, cosmetics, environment, fermentation, and exercise. We analyze samples derived from various foods, plants, animals, and microorganisms, measuring metabolites contained in the samples, such as amino acids, vitamins, and functional components. Would you like to clarify the potential of your materials and products that you haven't measured yet through metabolome analysis? We will propose a measurement plan suitable for your company's objectives. *For more details, please refer to the PDF materials or feel free to contact us.

• Other analyses
• Analysis Services
• Other contract services

"Mediator Scan" is a contract analysis service by HMT that scans lipid mediators. It comprehensively analyzes a total of 400 types of lipophilic metabolites, including representative groups of lipid mediators such as oxylipins, lysolipids, and steroids. It is particularly suitable for research related to inflammation, allergies, immunity, cancer, diabetes, and atherosclerosis. 【Features】 ■ Contract analysis service ■ Comprehensive analysis of 400 types of lipophilic metabolites ■ Well-suited for research related to cancer, diabetes, and atherosclerosis ■ For marker exploration and mechanism analysis *For more details, please refer to the PDF document or feel free to contact us.

• Public Testing/Laboratory
• Contract Analysis
• Contract Inspection

This document introduces the "Metabolome Contract Analysis Service," which corresponds to comprehensive analysis of metabolites using mass spectrometry. In addition to explanations of the analytical methods and equipment used in actual contract analyses, it also clearly presents an overview of "metabolome analysis," examples of "analysis data utilization," and "sample cases" using diagrams and tables. [Contents (Excerpt)] ■ What is metabolome analysis? ■ Metabolome analysis and mass spectrometry ■ Our technology and services ■ What can be done with metabolomics *You can view it immediately from "PDF Download." Please feel free to contact us.

• Contract Analysis
• Analysis Services
• Analytical Equipment and Devices

Our company offers a wide range of contract metabolome analysis services. One of our analysis services, the next-generation high-sensitivity metabolomics 'ω Scan', achieves the connection of capillary electrophoresis (CE) and high-resolution mass spectrometry (HRMS) through our patented technology, the "ion source adapter." This allows for the detection of substances present in low quantities, which was difficult with conventional mass spectrometry, and we expect approximately twice the number of detectable substances compared to our traditional method, CE-TOFMS. 【Application Fields】 ◎ Exploration of new markers (possibilities even in already analyzed fields) ◎ Research fields using the following sample types that require trace analysis: - Trace body fluids (sweat, tears, etc.) - Trace tissues (biopsies, etc.) - Extracellular vesicles (exosomes, etc.) - Trace cells (specific immune cells, stem cells) - Cell organelles (mitochondria, nucleus, etc.) ★ As an option, we offer a reporting service for the detection of dipeptide levels in samples called "Dipeptide Search." *For more details, please refer to the materials. Feel free to contact us with any inquiries.

• Public Testing/Laboratory

"F-Scope" is a new contract analysis service that allows for stable isotope labeling analysis. By analyzing metabolites labeled with 13C, it definitively presents the increase or decrease in activity for each metabolic pathway and the direction of those reactions. 【What is isotope labeling analysis?】 ■ Isotopes are atoms that have a different mass than those commonly found in nature. Since the isotopes remain unchanged even when the substrate containing them is metabolized and converted into another substance, they can be treated as "labels." ■ Mass spectrometers can distinguish between isotopes, allowing for the analysis of which metabolic pathway the substrate has gone through and what it has been converted into. *For more details, please refer to the PDF document or feel free to contact us.

• Other analyses
• Analysis Services

"Sea Scope" is a metabolome analysis service that measures metabolic fluctuations in central metabolism (energy, amino acids, nucleic acid metabolism) with high sensitivity and precision, detectable only by CE-QqQMS. Since absolute concentrations of metabolites can be obtained, it is possible to compare the pool sizes of different metabolites and calculate metabolic parameters such as the energy charge of nucleic acids and the pool size of function-specific amino acids. The metabolic parameters reported can only be calculated when the absolute amounts (concentrations) of metabolites are obtained. Knowing the concentrations allows for comparisons between different substances, adjustments between different substances, and comparisons of test data analyzed across different batches. 【Features】 ■ Understanding primary metabolism leads to a better understanding of life ■ Achieves excellent detection sensitivity and quantification range ■ Derives more rational interpretations from metabolic parameters ■ Enables immediate publication of research results *For more details, please refer to the PDF document or feel free to contact us.

• Contract measurement
• Other analyses
• Analysis Services

In the "Basic Scan," we extract information on approximately 1,000 metabolites registered in the HMT library from the data obtained through metabolome analysis and report the results. The library covers the majority of major metabolites (such as amino acids, nucleotides, nucleosides, phosphorylated organic acids, nucleobases, CoA derivatives, organic acids, etc.), making it suitable for monitoring basic metabolic changes and analyzing mechanisms. You can obtain foundational metabolic information to advance your research. 【Features】 ■ The library covers the majority of major metabolites ■ Only annotated peaks among the detected peaks are reported ■ Charts and graphs that can be directly used in papers are also reported ■ Reasonably confirm the profile of primary metabolites *For more details, please refer to the PDF materials or feel free to contact us.

• Contract measurement
• Other analyses
• Analysis Services