ノバ・バイオメディカル List of Products and Services

We will invite experts who are at the forefront of research on regenerative medicine, biopharmaceuticals, and clinical iPS cell extracellular vesicles using cultured cells to share the latest research information and future possibilities. Since this is a live broadcast, please be sure to register so you don't miss it. 【Nova Advanced Cell Science Seminar 2020 - The Future Opened by Cultured Cells】 ■ Date and Time: September 29, 2020 (Tuesday) 1:00 PM - 5:00 PM ■ Online live broadcast ■ Participation Fee: Free (Pre-registration required) (Organized by Nova Biomedical Corporation) ------------------------------------------------------------------------------------ ◆◆ Details & Registration ◆◆ https://www2.novabio.us/jp_seminar2020 ------------------------------------------------------------------------------------

• Seminar

Focusing on "cell proliferation," one of the indicators of cell quality, we compared the results of cell proliferation and culture medium component analysis when changing the culture conditions. This is the result data from an experiment where the frequency of medium exchange was set to three conditions during the maintenance culture of iPS cells in a feeder-free environment, followed by three passages. In this verification, we used the cell culture environment analysis device "BioProfile FLEX2." The "BioProfile FLEX2" is a non-invasive, low-sample-volume device that can measure up to 16 items, including metabolites and cell viability, in just 4 minutes and 30 seconds, or 2 minutes with individual modules. 【Product Specifications】 Analysis Items: Glucose/Lactate/Glutamine/Glutamate/NH4+/Na+/K+ Ca++/pH/pO2/pCO2/Total Cell Density/Viable Cell Density/Viability/Cell Diameter/Osmolality Automatic Calibration: 2 hours (fixed)/Time required 2 minutes Operating Environment: Temperature 10–30°C, Humidity 20–85% 【Features】 ■ Simultaneous analysis of up to 16 items ■ Measurement time: as short as 2 minutes, as long as 4 minutes and 30 seconds (depending on measurement items) ■ Measurement of consumption and production rates of major metabolites ■ Compatible with multiple shapes of sample containers ■ Equipped with an auto-sampling function for continuous measurement

• Other bio-related products
• Other Culture
• Other analytical and testing equipment

□■ Latest Webinar Title □■ ------------------------------------------------------------------------------------- Possibilities of Measuring Medium Components in Cell Manufacturing Speaker: Masahiro Kinooka, Ph.D. (Professor, Osaka University Graduate School) ------------------------------------------------------------------------------------- In applying to process management for cell manufacturing that contributes to regenerative medicine, methods that do not affect production are required. The opportunities for cell measurement technologies are limited, and environmental measurements are also necessary. In this webinar, we will focus on medium component measurement technology within environmental measurements and introduce the possibilities of medium measurement for understanding cell and culture conditions based on our experience in measuring medium components.

• Seminar
• Other Culture
• Other analytical and testing equipment

This is an analysis service for cell culture media using the NOVA Biomedical FLEX2 automated analysis system. There is a possibility of gaining insights that can only be understood through cell culture environment analysis. Why not analyze the cell culture environment in your laboratory once? We analyze 8 metabolic and electrolyte parameters from 500μl of culture media. Metabolic components: Glucose, Lactate, Glutamine, Glutamate Electrolytes: NH4+, Na+, K+, Ca2+

• Cell culture contract service
• Other bio-related products and services
• Other Analysis

This seminar is fully booked. Thank you for the many attendees. You will hear a wide range of lectures from basic research in academia to industrial applications in pharmaceuticals and venture companies. A networking event will also be held after the seminar. We look forward to your participation. [Nova Advanced Cell Science Seminar - The Future Opened by Cultured Cells] ■ Date: August 1, 2019 (Thursday) 1:00 PM - 6:00 PM (Networking event 6:00 PM -) ■ Venue: Shinagawa Prince Hotel Main Tower Diamond 30 ■ Participation Fee: Free (Networking event participation: Free) ■ Capacity: 200 people ■ Organized by: Nova Biomedical Corporation Application Deadline: July 22 (Monday) *Applications are closed due to full capacity.

• Seminar

The "Stat Profile Prime" is a cell culture medium analysis device that can measure a total of 9 items, including pH, PCO2, PO2, and Na+. Calibration and precision management are automatically performed to ensure that measurements of the 9 items can be conducted in approximately 1 minute at all times. Additionally, the Prime's individual cartridge system can be attached to the device immediately after opening, and the replacement process takes only a few seconds, maximizing the usable time of the analysis device. 【Features】 ■ Measurement of 9 items (pH, PCO2, PO2, Na+, K+, Cl, Ca+, Gluc, Lac) ■ Zero maintenance cartridge technology ■ High-speed throughput and small sample volumes ■ Automatic QC function *For more details, please refer to the PDF document or feel free to contact us.

• Other analytical and testing equipment
• Other Culture

The "BioProfile FLEX2" is an automated analysis device for cell culture environments that can simultaneously analyze up to 16 components of cell culture media. In just 4.5 minutes, it quantifies culture conditions such as metabolism, proliferation, and differentiation, contributing to the efficiency of "continuity assessment of the cell manufacturing process," "creating a culture environment with an eye on mass production," and "quality control and documentation of standards in line with GMP compliance." It is equipped with sample containers of various shapes, requiring a small sample volume of 135 to 265 μL. For chemical substances and gas measurements, it uses sensor cards that do not require electrode maintenance. 【Features】 ■ Capable of simultaneous analysis of up to 16 items ■ Rapid measurement time: as short as 2 minutes and as long as 4 minutes and 30 seconds (depending on the measurement item) ■ Can measure the consumption and production rates of major metabolites 【Exhibition Information】 Name: BioJapan 2024 Venue: Pacifico Yokohama D-39 Date: October 9-11, 2024 Featured Products: Demonstration of "BioProfile FLEX2" and "BioProfile FAST CDV" media analysis! A 70% off campaign for "Stat Profile Prime" is currently underway! (Until the end of December) *Analysis explanation materials are currently available! Please check from "PDF Download."

• Other physicochemical equipment

The fully automated cell density/survival rate analyzer "BioProfile FAST CDV" requires only 100μL of sample for cell counting. With continuous processing through a dual flow path, it achieves a high throughput of over 45 measurements per hour. It can automatically measure high-density cells up to 1.4×10^8 cells/mL without manual dilution. The measurement and maintenance processes are thoroughly simplified with automatic handling of dilution, staining, and viability assessment, as well as large-capacity, pack-style reagents. 【Features】 - Required sample: 100µL - Rapid measurement: over 45 measurements per hour high throughput - Various sampling methods including 32-position trays and 96-well plates - Measurement range of 0.5×10^5 - 1.4×10^8 cells/mL without manual dilution - Continuous measurement of up to 500 samples with large-capacity reagent packs - Automatic flow path flushing to prevent clogging - Compliant with 21 CFR Part 11; can be utilized for GMP compliance - Capable of network transfer of data and images *For detailed specifications, please download from below. Feel free to inquire about product descriptions, demos, and quotes. Inquiries about FLEX2 (automated analysis system for cell culture environments) are also welcome.

• Particle Counter

The "BioProfile FLEX2" is an automatic analysis device that can measure up to 16 items, including major metabolites and gas components in cell culture media, osmotic pressure of the culture medium, and cell proliferation, in approximately 4.5 minutes. It can measure multiple items at once, requiring a minimal sample volume of up to 245μL. With easily replaceable sensor cards and a pack-style design, maintenance time is reduced. The online feature also allows for auto-sampling from bioreactors (optional). It is ideal for managing the manufacturing processes of cell processing products and antibody pharmaceuticals, exploring optimal culture conditions for cell culture, and collecting fundamental data to ensure reproducibility and reliability in cell-based research. It also supports data integrity and GMP-compliant validation. 【Features】 ■ No need for measurements with multiple machines, reducing labor hours ■ Non-invasive measurements are possible ■ Auto-sampling for up to several weeks is possible (in collaboration with other systems) ■ Automatic quality control functions within the device ensure verification of performance accuracy ■ Extensive support services (installation, repair, technical support via phone and email, etc.) *For more details, please refer to the PDF document or feel free to contact us.

• Other environmental analysis equipment

The automatic analysis device for cell culture environments, "BioProfile FLEX2," can simultaneously measure 16 essential parameters for cell culture, including metabolism, gas, pH, and cell size, from small samples in just four and a half minutes. In addition to non-invasive sample analysis, the use of cartridge systems makes maintenance, such as waste liquid disposal, easy and helps prevent biohazards. By quantifying the components of the culture medium, the reproducibility and reliability of research using cells can be enhanced, allowing for seamless control of the culture environment from basic research to large-scale commercial production. 【Features】 ■ Reduction of labor and manpower through automation ■ Analysis possible with small samples ranging from 135μL to 275μL ■ Measurement possible in as little as 2 minutes for chemical substances only ■ Non-invasive, capable of measuring with small samples, easy operation and data collection ■ GMP compliant, 21 CFR Part 11 compliant, data integrity ■ Easy maintenance with sensor card type and pack type reagents *We are currently offering a "Guidebook for Analyzing Culture Medium Components for Culture Environment Control," which summarizes product introductions, basic knowledge about analysis items, and a publication list. Please check it along with the catalog in the "PDF download."

• Analytical Equipment and Devices

A cell counter capable of high throughput with over 45 measurements per hour - Can measure small samples (100μL) - High throughput rapid measurement of approximately 45 measurements per hour - Wide measurement range: 0.5×1,000,000 to 1.4×100,000,000 cells/mL - Automatic analysis without external dilution due to internal dilution function - Continuous sampling from 32-position dedicated sample cups or 96 deep well plates - Compliant with 21 CFR Part 11 - Supports network transfer of data and images - Easy maintenance with packaged reagents

• Other physicochemical equipment

The "BioProfile FLEX2" is an automatic analysis device that can measure up to 16 items, including major metabolites and gas components in cell culture media, osmotic pressure of the culture medium, and cell proliferation, in approximately 4.5 minutes. It can measure multiple items at once, and the required sample volume is as low as 245μL. The sensor card, which allows for easy replacement of consumables, and the pack-style design reduce maintenance time. An online function also enables auto-sampling from bioreactors (optional). It is suitable for managing the manufacturing processes of cell processing products and antibody pharmaceuticals, exploring optimal culture conditions for cell culture, and collecting fundamental data to ensure reproducibility and reliability in cell-based research. It also supports data integrity and compliance with GMP validation. 【Features】 ■ No need for measurements with multiple machines, reducing labor hours ■ Non-invasive measurements are possible ■ Auto-sampling for up to several weeks is possible (in collaboration with other systems) ■ Automatic quality control functions within the device ensure verification of true performance values ■ Extensive support services (installation, repairs, technical support via phone and email, etc.) *For more details, please refer to the PDF document or feel free to contact us.

• Other environmental analysis equipment

To prevent the spread of the novel coronavirus (COVID-19), the urgent development of vaccines is required. It is said that managing the culture environment is crucial in the process of vaccine research and development involving host cell cultures. The "BioProfile" series of cell culture environment analysis devices from Nova Biomedical is widely adopted by major pharmaceutical companies and institutions in Japan and around the world for managing culture environments in vaccine research, development, and manufacturing processes. At Nova Biomedical, we hope to contribute, albeit modestly, to the development of COVID-19 vaccines by offering flexible purchasing programs tailored to your budget. For more details, please contact us through the inquiry form, and we will respond promptly. We also have materials available for cell culture analysis using our devices. 【Features】 - Monitoring the progress of cell culture - Quantification of key components in the culture medium - Early detection of abnormalities in the culture environment through regular monitoring - Capability to measure multiple items with one device, significantly reducing measurement time by consolidating the functions of multiple devices into one - Numerical backing for the timing of medium changes - Maintenance-free and sensor card-based, reducing the workload for researchers on equipment maintenance

• Other physicochemical equipment

There is data indicating that "an appropriate culture medium environment correlates with an increase in cell numbers," which necessitates the creation and adjustment of an appropriate culture medium environment to promote efficient cell culture. Are you unable to execute this due to the "time required for measurement and analysis" being a bottleneck? The cell culture environment automatic analysis device 'BioProfile FLEX2' can analyze the components of cell culture media for up to 16 items in just 4.5 minutes. It allows for rapid quantification of culture conditions such as metabolism, proliferation, and differentiation, contributing to the establishment of a culture environment aimed at mass production. ★ We are currently offering materials that investigate the correlation between changes in medium components and cell numbers in iPS cell culture. 【Features】 ■ Simultaneous analysis of up to 16 items ■ Rapid measurement time: as short as 2 minutes, up to 4 minutes and 30 seconds (depending on measurement items) ■ Capable of measuring consumption and production rates of major metabolites ■ Compatible with multiple shapes of sample containers ■ Equipped with an auto-sampling function for continuous measurement of samples *For more details, please refer to the materials available for download in PDF format.

• Analytical Equipment and Devices
• Other measurement, recording and measuring instruments

The "BioProfile FLEX2" is an analytical device that utilizes micro-sensor technology. This technology allows the "BioProfile FLEX2" to achieve "reduced maintenance related to electrodes," "shortened measurement time," and "significantly reduced sample volume," making it an automatic analysis device for cell culture environments. It can measure all 16 parameters with a minimal sample volume, completing all 16 measurements in just 4 minutes and 30 seconds, or 2 minutes for individual modules. 【Features】 ■ Monitoring the progress of cell culture ■ Quantification of key components in the culture medium ■ Early detection of abnormalities through regular monitoring ■ Capability to measure multiple parameters with one device, consolidating the functions of multiple devices into one ■ Numerical backing for the timing of medium exchange *For more details, please request documentation or view the PDF data available for download.

• Other physicochemical equipment

This document is a verification report that measures parameters in the culture supernatant during the maintenance culture of iPS cells and the differentiation induction process from iPS cells to dopamine-producing neural progenitor cells, exploring applications for evaluating cell quality and experimental systems. In addition to the experimental content and the composition of reagents and media, it discusses differentiation induction and maintenance culture. 【Contents】 ■ Purpose ■ Experimental Content ■ Reagents and Media Composition - Differentiation induction into neural progenitor cells - iPS cell culture ■ Discussion *For more details, please refer to the PDF document or feel free to contact us.

• others

The "BioProfile pHOx" is a compact and user-friendly automatic analyzer for animal cell culture media. It is designed to quickly and accurately measure pH, PCO2, and PO2 in animal cell culture samples. With a liquid calibration cartridge system, there is no need for gas tanks, regulators, or humidifiers. 【Features】 ■ Compact design ■ Designed to measure pH, PCO2, and PO2 ■ Equipped with a liquid calibration cartridge system *For more details, please refer to the catalog or feel free to contact us.

• Analytical Equipment and Devices