フィジオマキナ List of Products and Services

The "Dashboard" is a product that automates the input of necessary values by connecting electronic scales, thickness gauges, and hardness testers to GTP-2. The software automatically generates multiple approaches to the results obtained from measurements. This allows for the evaluation of powders from a greater number of perspectives. 【Features】 ■ Input of values is completed with one click ■ Various plots are automatically generated *For more details, please refer to the related links or feel free to contact us.

"ExtruVis" is a system that automatically measures residence time distribution by connecting a PC with dedicated software installed to a camera. The main tasks before use are alignment and the preparation is very simple. It guides the analysis of recorded measurement values, allowing access to results in just a few seconds. Please feel free to contact us when you need assistance. 【Features】 ■ Simple preparation ■ Effective software *For more details, please refer to the related links or feel free to contact us.

The "mini-DT" is a dissolution tester specialized for small volumes. It requires minimal installation space, with a width of 350mm and a depth of 300mm, allowing for testing in 8 positions. You can choose from vessels of 100mL, 150mL, 200mL, and 250mL. 【Features】 ■ Four volume options available ■ Can be connected to Rainbow ■ Space-saving design *For more details, please refer to the related links or feel free to contact us.

The "ProMixer" is a powder mixer designed for small volumes that can be used on a tabletop. You can choose between a standard drum type and a V-type. It can be used for volumes ranging from a minimum of 13 to 90 mL, and a maximum of 75 to 450 mL. Please feel free to contact us if you have any inquiries. 【Features】 ■ Two types of drums available ■ Suitable for small volumes *For more details, please refer to the related links or feel free to contact us.

"Rainbow" is a system that enables in situ UV monitoring at intervals as short as 2 seconds without the need for sampling by installing probes in test liquids such as vessels and bioreactors. The included AuPRO software is equipped with features that maximize UV monitoring capabilities, such as secondary differential analysis and the Zero Intercept Method, allowing for many tests that were previously difficult to achieve. Please feel free to contact us when you need assistance. 【Features】 ■ Wide range of concentration measurements possible by replacing dedicated probe tips ■ AuPRO software enabling advanced analysis ■ Suitable for a wide range of applications *For more details, please refer to the related links or feel free to contact us.

The "μDISS" is a system that combines the Rainbow and Mini-Bath manufactured by Pion. It uses a 25mL glass vial, allowing for solubility measurements with a small volume. Additionally, by using an optional insert, it is also possible to conduct solubility measurements with a minimum of 1mL. Besides solubility measurements, it can also be used for salt screening and supersaturation evaluation. 【Features】 ■ Enables solubility measurements with a small sample ■ Allows for the evaluation of supersaturation duration ■ Supports salt screening *For more details, please refer to the related links or feel free to contact us.

The "Sirius T3" is an automatic titration device for measuring the fundamental physical property values of compounds (pKa, logP, solubility). Using titration methods, it accurately measures the basic physical property values of compounds and can handle poorly soluble compounds. Please feel free to contact us when you need assistance. 【Features】 ■ pKa measurement can choose between UV method and potentiometric titration method ■ Supports pKa measurement of poorly soluble compounds ■ Enables evaluation of the lipophilicity of compounds ■ Supports solubility measurement ■ Monitors the precipitation of compounds during measurement *For more details, please refer to the related links or feel free to contact us.

"Crystal16" is a crystallization device that solves issues related to crystallization in general. It allows for the setting of stirring speed, stirring time, starting temperature of the experiment, heating rate, cooling rate, and holding time. Users can set the solvent and sample concentration as experimental conditions. Additionally, it is possible to set the cooling rate and choose the solvent. 【Features】 ■ Capable of setting 16 different crystallization conditions at once ■ Can configure settings to discover crystal polymorphs ■ Selection of stirring shapes is possible ■ Equipped with data analysis software (Crystal Clear) ■ Generates reports in Word format *For more details, please refer to the related links or feel free to contact us.

"Crystalline" is a crystallization device equipped with measurement capabilities similar to those of Crystal16. It can acquire the Raman spectrum of the produced crystals. Additionally, by confirming crystallization through camera images, various particle information can be obtained. Please feel free to contact us when you need assistance. 【Features】 ■ Capable of setting up to 8 different crystallization conditions at once ■ Equipped with measurement capabilities similar to Crystal16 ■ Capable of acquiring Raman spectra ■ Phenomena within the tube can be confirmed through camera images ■ Equipped with dedicated data analysis software *For more details, please refer to the related links or feel free to contact us.

ReactALL, co-developed with Pfizer, is an innovative benchtop multi-reactor system equipped with both novel automatic sampling and overhead stirring functions, making it ideal for medium throughput experiments. This cutting-edge device is specially designed to meet the needs of screening and optimizing chemical reactions, including route scouting and process development and optimization. Due to its medium throughput capability, it allows testing with small amounts of raw materials and reagents. The sampling mechanism can perform up to 18 samples during testing, while the stirring mechanism can suspend solids without grinding them, anticipating actual manufacturing needs. Additionally, an integrated camera allows for monitoring and profiling of particle size and shape, effectively addressing uneven reactions. All of this is achieved using Techobis's SmartCap technology, utilizing standard vials with a reaction volume of 5 to 10 mL. Furthermore, this SmartCap technology ensures that solvent loss during a 20-hour test under heating conditions remains within 10%, providing a highly airtight structure.

We would like to introduce a case study on the use of the crystallization device "Crystal16." We are considering a method to apply this device to observe the phase separation and re-mixing behavior of mixed solutions. Two types of stirring mechanisms, Bottom Stirrer and Top Stirrer, can be used. When using the Top Stirrer, it was confirmed that the liquid surface can be stirred with sufficient strength, ensuring that the contents of the vial are uniformly mixed and suspended. As the name suggests, this product's main application is to obtain solubility curves through crystallization operations of solids; however, it has also been confirmed that it can be used to determine the critical temperature in mixed solutions. [Background] - In the case of non-miscible mixed solutions, it is generally observed that increasing the temperature makes them easier to mix, while lowering the temperature leads to phase separation. - On the other hand, some mixed solutions become mixed when the temperature is lowered and undergo phase separation as the temperature rises. *For more details, please download the PDF or feel free to contact us.

We would like to introduce a case study on the utilization of the crystallization device "Crystalline." Using this device (manufactured by Technobis), which has a camera function, we confirmed the timing of the transition between crystal forms and whether we could easily set conditions to recover the desired crystal form. In cases like carbamazepine, where the crystal form transitions rapidly, it is necessary to accurately grasp the timing of crystal generation and the transition of crystal forms in order to obtain the crystal form before the transition. By using the camera function of this device, we can observe the situation inside the vial and easily confirm the desired timing. [Test] - Carbamazepine yields needle-like Type II crystals through rapid cooling, which then transition to block-like Type III crystals. - Measurements were conducted using the following program to confirm the timing of Type II crystal generation and the transition to Type III crystals: - Raise the solution temperature to 70°C and confirm that carbamazepine is completely dissolved. - Cool to 20°C at -20°C/min. - Hold at 20°C for 4 hours. *For more details, please download the PDF or feel free to contact us.

We would like to introduce a case study on the application of the membrane permeability measurement system "μFLUX." In our previous research, we developed a sustained-release formulation containing an alkalizer, and we attempted to apply this device to evaluate its usefulness in reducing gastric mucosal damage caused by DC. In this study, we only simulated the pH environment, but incorporating other components such as lipids and proteins is expected to lead to a more accurate evaluation. 【Case Overview】 ■ Study - Evaluated the impact of pH fluctuations in the microenvironment caused by the alkalizer on the membrane permeability of the acidic drug DC using μFLUX. ■ Results - It was demonstrated that μFLUX could be a useful tool not only for evaluating drug absorption but also for assessing the risk of side effects caused by drug accumulation in tissues. *For more details, please download the PDF or feel free to contact us.