自然免疫応用技研 List of Products and Services

"Somacy-CL001" is an LPS for liquid-type cosmetics. It is produced by extracting and purifying LPS from wheat Pantoea bacteria that were fermented and cultured in a medium containing wheat flour. It is recommended to incorporate it into cosmetics at a concentration of 0.3-1% (0.3-1μg/g as LPS). 【Features】 ■ For cosmetics ■ Derived from Pantoea agglomerans LPS ■ Water-soluble *For more details, please refer to the catalog or feel free to contact us.

• Cosmetic materials and raw materials

This document is a research report investigating the effects of a moisturizing cream containing glycosphingolipids (LPS) on atopic dermatitis symptoms, which were observed symmetrically on both sides of the body in four individuals who were not using any medications such as steroids. For four weeks, one side was treated with the moisturizing cream containing LPS, while the other side received a placebo cream, applied twice daily, with the cooperation of a dermatologist. The study was conducted in a double-blind manner, and the changes in the EASI score were monitored. The results of the study indicated that glycosphingolipids (LPS), when combined with a high-quality moisturizing base, could be expected to improve allergic skin irritation. [Research Content] ■ Human efficacy verification study on atopic dermatitis using cosmetics containing LPS materials *For more details, please refer to the catalog or feel free to contact us.

• Food/beverage functional materials
• Cosmetic materials and raw materials
• Other Media

This document is a research report on a human efficacy verification study for diabetes using tea targeted at diabetes prevention, which incorporated LPS materials. The study found that for fasting blood glucose, both the test group and the control group showed a statistically significant decrease due to the glucose absorption inhibitory activity inherent in Salacia. However, statistically significant decreases in HbA1c and LDL were observed only in the test group. Further analysis of the decreases in HbA1c and LDL revealed that this effect was particularly evident in individuals who initially had high lipid metabolism markers. These results indicate that pantethine glycosphingolipids (LPS) have the effect of improving lipid and glucose metabolism in individuals with elevated blood lipids. [Research Content] ■ Human efficacy verification study for diabetes using LPS material-containing foods *For more details, please refer to the catalog or feel free to contact us.

• Food/beverage functional materials
• Cosmetic materials and raw materials
• Other Media

This document is a research report on "Substances that Act on Immunity," which compares the macrophage activation abilities of gram-negative bacteria; glycolipids (LPS) and the peptidoglycan (from dead lactic acid bacteria), as well as β-glucan (from baker's yeast) extracted from yeast. This study found that, in terms of macrophage activation power, glycolipids (LPS) have a higher superiority compared to peptidoglycan and β-glucan, and are effective in trace amounts. [Research Content] ■ Substances that Act on Immunity *For more details, please refer to the catalog or feel free to contact us.*

• Food/beverage functional materials
• Cosmetic materials and raw materials
• Other Media

"APV-CL001" is an LPS for liquid-type cosmetics. It is produced by extracting LPS from the culture solution of apple-derived Pantoea bacteria. It appears colorless to yellow and has a slight odor. We recommend a formulation of 0.3-1% (0.3-1μg/g as LPS) in cosmetics. 【Features】 ■ Liquid product ■ For cosmetics ■ LPS derived from apple Pantoea bacteria *For more details, please refer to the catalog or feel free to contact us.

• Yeast and fungi
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

"RiB-CL001" is a liquid-type LPS for cosmetics. It is produced by extracting LPS from a culture solution fermented with rice bran using the bacterium Paenibacillus polymyxa. It appears colorless to pale yellow and has a slight odor. We recommend a formulation of 0.3-1% (0.3-1μg/g as LPS) in cosmetics. 【Features】 ■ Liquid product ■ For cosmetics ■ LPS derived from Paenibacillus polymyxa *For more details, please refer to the catalog or feel free to contact us.

• Yeast and fungi
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

"SomacyRB-FP100" is a powdered type of food-grade LPS. It is extracted and adjusted from a culture solution fermented with wheat Panthoea bacteria using rice bran, and then spray-dried with dextrin as a carrier. We recommend incorporating 15 to 50 mg into food per day. [Features] ■ Powdered product ■ Food-grade ■ LPS derived from wheat Panthoea bacteria *For more details, please refer to the catalog or feel free to contact us.

• Food/beverage functional materials
• Food ingredients (liquid)
• Yeast and fungi

"Somacy-FP100" is a powdered type of food-grade LPS. It is extracted and adjusted from a culture solution fermented with wheat flour using wheat Pantoea bacteria, and then spray-dried with dextrin as a carrier. Its appearance is white to light yellow. We recommend incorporating 15 to 50 mg into food per day. 【Features】 ■ Powdered form ■ Food grade ■ Derived from wheat Pantoea bacteria *For more details, please refer to the catalog or feel free to contact us.

• Food/beverage functional materials
• Food ingredients (liquid)
• Yeast and fungi

"Somacy-FL100" is a liquid-type food-grade LPS. It is produced by extracting and adjusting a culture solution fermented from wheat flour with the bacterium Pantoea agglomerans. It has a yellow to brown color and a slight odor. We recommend incorporating 15 to 50 mg into food per day. 【Features】 ■ Liquid product ■ Food grade ■ LPS derived from Pantoea agglomerans *For more details, please refer to the catalog or feel free to contact us.

• Food/beverage functional materials
• Food ingredients (liquid)
• Yeast and fungi