重松貿易 Product Lineup

<Introduction> Antibodies are challenging molecules to characterize due to their size and complexity. A compelling approach to combat diseases such as cancer is to conjugate drugs (payloads) to antibodies, but this further increases the risks of complexity and heterogeneity. Antibody-drug conjugates (ADCs), like other IgG-based biopharmaceuticals, require careful and detailed characterization and appropriate analytical workflows. The "FabRICATOR" product from Genovis allows for the digestion of ADCs into subunits, enabling detailed characterization of this complex class of drugs. Additionally, the endoglycosidases "IgGZERO" and "GlycINATOR" help reduce complexity and improve resolution, making intact ADC studies possible. [Genovis actively hosts web meetings and seminars. Please feel free to contact us for adjustments according to your needs.]

• Research Antibodies
• Other protein analysis
• Other analytical and testing equipment

IgGZERO (EndoS) is an endoglycosidase derived from Streptococcus pyogenes that hydrolyzes the N-linked glycans in the Fc region of IgG. It is useful for reducing complexity through rapid deglycosylation of IgG and inactivating the effector functions of the Fc region. This enzyme deglycosylates IgG from various animal species, including human IgG (all subclasses), as well as IgG from mice, rats, monkeys, sheep, goats, cows, and horses. The enzyme specifically hydrolyzes only the glycans in the Fc region of IgG, even in the presence of other glycosylated proteins in solution. It is expressed and produced in E. coli, contains a His tag, and has a molecular weight of 110 kDa. Genovis actively holds web meetings and seminars. Please feel free to contact us for adjustments according to your requests.

• Other protein analysis
• Other analytical and testing equipment
• Research Antibodies

FabRICATOR (IdeS) is a unique enzyme that digests specific sites just below the hinge region of antibodies. It generates a uniform pool of F(ab')2 and Fc/2 with a 30-minute incubation. No substrates other than IgG are known. Typically, IgG is digested within 30 minutes, but there is no risk of excessive digestion even with longer incubation times. FabRICATOR digests IgG under physiological conditions, maintaining its immunoreactivity. The enzyme activity is maximized at 37°C, but it can also be used at room temperature by extending the reaction time. FabRICATOR digests all subclasses of IgG from humans, monkeys, rabbits, and sheep. However, its activity against mouse IgG2a and IgG3 is limited. For the digestion of these antibodies, the use of FabRICATORZ is recommended. ● Genovis actively holds web meetings and seminars. Please feel free to contact us for adjustments according to your requests.

• Research Antibodies
• Other protein analysis
• Other analytical and testing equipment

"MolYsis" is a tool that removes human DNA and concentrates bacterial and fungal DNA from liquid samples. Technically, it is effective in a short series of steps for the selective lysis of blood cells and the quantitative degradation of released human DNA (>99%). After the lysis solution is concentrated by centrifugation, the microorganisms are treated with reagents that break down the cell walls of gram-positive bacteria, gram-negative bacteria, and fungi. It has been clinically evaluated for a wide range of microbial lysis, demonstrating effectiveness against over 200 species of bacteria and 65 species of fungi. [Features] - Removes human DNA - Selectively concentrates bacterial and fungal DNA - Removes PCR inhibitors - Dissolves a wide range of bacteria and fungi *For more details, please refer to the PDF materials or feel free to contact us.

• Other Nucleic Acid/DNA Research
• Real-time PCR
• Other Amplification/PCR

At Levena Biopharma, we have experienced scientists involved in the modification of ADCs, capable of providing rapid PoC regardless of scale. By combining linker payloads and modification methods, we offer high-quality custom ADCs at competitive prices. Our services include comprehensive reports that contain characteristic specifications. We also have a proven track record of supplying over a hundred types of ADCs made from human, mouse, or rat IgG1 or IgG2, at scales ranging from 1mg to 200mg. 【ADC Characterization Methods, etc.】 ■ Analytical Tools: HPLC (HIC, SEC, RP), iCIEF, LC-MS ■ Quality: Drug-to-Antibody Ratio (DAR), purity via SDS-PAGE, aggregation, endotoxins, residual drugs ■ In vitro Pharmacology: Over 100 common tumor cell lines for cytotoxicity studies ■ ADC reference standards are also available for comparative characterization ■ Development of analytical methods and stability studies ■ Scale-up and process development services to commercial scale *For more details, please refer to the external link page or feel free to contact us.

• Custom reactions and synthesis
• Other contract services

The product is a glass plate coated with fluorescent indicator F254 silica gel. It is a 320 glass plate measuring 2.5×7.5 cm. 【Data Sheet】 ■ Name: HPTLC Silica Gel 60 GF254 ■ Number: CS-E0009 ■ Material: Glass support, silica gel matrix ■ Features: Binder high molecular fluorescent indicator ■ Packaging: 320 units in a fiber case ■ L×W: 2.5×7.5 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 0.25 mm *You can download the English version of the catalog. *For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
• others

The product is a glass plate coated with fluorescent indicator F254 silica gel. It is a 640 glass plate measuring 2.5×5.0 cm. 【Data Sheet】 ■Name: HPTLC Silica Gel 60 GF254 ■Number: CS-E0010 ■Material: Glass support, silica gel matrix ■Features: Binder high molecular fluorescent indicator ■Packaging: 640 units in a fiber case ■L×W: 2.5×5.0 cm ■Shipping: Ambient ■Storage Temperature: Room temperature, caution with humidity ■Layer Thickness: 0.25 mm *You can download the English version of the catalog. *For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
• others

The product is a glass plate coated with fluorescent indicator F254 silica gel. It is an 80 glass plate measuring 5.0×20 cm. 【Data Sheet】 ■ Name: HPTLC Silica Gel 60 GF254 ■ Number: CS-E0011 ■ Material: Glass support, silica gel matrix ■ Features: Binder polymer fluorescent indicator ■ Packaging: 80 units in a fiber case ■ L×W: 5.0×20 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 0.25 mm * You can download the English version of the catalog. * For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
• others

The product is a glass plate coated with fluorescent indicator F254 silica gel. It is a 20 glass plate measuring 20×20 cm. 【Data Sheet】 ■ Name: HPTLC Silica Gel 60 GF254 ■ Number: CS-E0013 ■ Material: Glass support, silica gel matrix ■ Features: Binder high polymer fluorescent indicator ■ Packaging: 20 units in a fiber case ■ L×W: 20×20 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 0.25 mm * You can download the English version of the catalog. * For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
• others

The product is a glass plate coated with fluorescent indicator F254 silica gel. It is an 800 glass plate measuring 2.0×5.0 cm. 【Data Sheet】 ■ Name: HPTLC Silica Gel 60 GF254 ■ Number: CS-E0020 ■ Material: Glass support, silica gel matrix ■ Features: Binder polymer fluorescent indicator ■ Packaging: 800 units in a fiber case ■ L×W: 2.0×5.0 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 0.25 mm * You can download the English version of the catalog. * For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
• others

The product is a glass plate coated with fluorescent indicator F254 silica gel. It is a 20 glass plate measuring 20×20 cm. 【Data Sheet】 ■ Name: PLC Silica Gel 60 GF254 ■ Number: CS-E0007 ■ Material: Glass support, silica gel matrix ■ Features: Binder polymer fluorescent indicator ■ Packaging: 20 units in a fiber case ■ L×W: 20×20 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 1 mm *You can download the English version of the catalog. *For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
• others

The product is a glass plate coated with silica gel and fluorescent indicator F254. It is a 20 cm x 20 cm glass plate. 【Data Sheet】 ■ Name: PLC Silica Gel 60 GF254 ■ Number: CS-E0014 ■ Material: Glass support, silica gel matrix ■ Features: Binder polymer fluorescent indicator ■ Packaging: 20 units in a fiber case ■ L×W: 20×20 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, with attention to humidity ■ Layer Thickness: 0.5 mm *You can download the English version of the catalog. *For more details, please refer to the PDF materials or feel free to contact us.

• Gelling Agent
• others

The product is a silica gel coated with aluminum TLC plates and fluorescent indicator F254. It consists of 25 aluminum sheets measuring 20×20 cm. 【Data Sheet】 ■ Name: HPTLC Silica Gel 60 F254 ■ Number: CS-E0008 ■ Material: Aluminum carrier, silica gel matrix ■ Features: Binder polymer fluorescent indicator ■ Packaging: 25 units in a fiber case ■ L×W: 20×20 cm ■ Shipping: Ambient ■ Storage Temperature: Room temperature, caution with humidity ■ Layer Thickness: 0.2 mm * You can download the English version of the catalog. * For more details, please refer to the PDF document or feel free to contact us.

• Gelling Agent
• others

Our company supports the synthesis of metabolites from drug candidates (compounds) by utilizing a panel of "synthetic chemical liver" that mimics a set of human liver cell cytochrome P450 enzymes (CYP). This multi-well panel, produced using organometallic catalysts, mimics a set of cytochrome P450 enzymes (CYP) found in human liver cells. By leveraging this tool, we support the synthesis of metabolites from drug candidates. 【Features】 ■ A diverse panel that mimics the main reactions occurring during drug metabolism ■ Utilizes biomimetic catalysts that include metalloporphyrins ■ Rapid identification of reaction conditions for generating drug metabolites *For more details, please refer to the PDF document or feel free to contact us.

• Custom reactions and synthesis
• Other contract services

We would like to introduce ChemScene's "HPTLC Silica Gel Plates," which we handle. They achieve high separation capability and contribute to cost performance. You can choose plates from a variety of sizes (from 20x20cm to 2.5x5cm, etc.). The products that are pre-cut can be used as they are. 【Features】 ■ Uniform and smooth silica gel surface coating ■ Achieves high separation capability ■ Can be repurposed for PLC (preparative use) ■ Contributes to cost performance ■ Choose plates from a variety of sizes (from 20x20cm to 2.5x5cm, etc.) ■ Pre-cut products can be used as they are (CS-E0009, CS-E0010, CS-E0020) *For more details, please refer to the external link page or feel free to contact us.

• Other experimental consumables
• others

The "PhotoRedOx Box" is a photochemical reaction device designed to allow researchers to easily and reproducibly conduct various light-induced redox reactions. It can deliver uniform light to all samples, achieving consistent reaction reproducibility. Additionally, thanks to the cooling fan, the internal temperature of the device can be maintained close to room temperature even during long reactions. The device is compatible with standard stirrers, allowing for consistent stirring. The sample holder accommodates vials ranging from 0.3ml to 20ml. 【Features】 ■ Simultaneously irradiates multiple samples with light while controlling the heat emitted by the light source ■ Achieves compactness and efficiency in reactions suitable for use with standard stirrers ■ The lamp adapter is removable, allowing for replacement with light sources of various wavelengths ■ Enables consistent work from reaction screening to scale-up in a short period ■ Saves time by eliminating the need to consider the distance from the light source to the samples *For more details, please refer to the external link page or feel free to contact us.

• Other experimental equipment and supplies
• Other research software
• others