メイワフォーシス List of Products and Services

Using the latest photoporation technology, a wide variety of cells, including iPS cells and CAR-T cells, can be introduced with various substances such as nucleic acids, proteins, and CRISPR/Cas9 RNPs. This method provides minimal damage during introduction, high survival rates, and achieves efficient transfection with high throughput. Photoporation is a gentle method for delivering payloads to cells based on the interaction between pulsed laser light and photothermal nanosenstizers. When laser light is applied to unique nanosenstizers adjacent to the cells, temporary pores are formed in the cell membrane through localized plasmonic reactions, allowing external payloads to enter the cytoplasm with minimal impact on cell survival and function. This technology serves as a next-generation transfection platform that efficiently, flexibly, and safely delivers various payloads to a wide range of cells, including primary cells, where transfection is challenging.

• Genetic Analysis Software

Cutting-edge visualization using fluorescent staining The characteristics of Acoerela dye are its high quantum yield (>25%) and specificity. A significant increase in fluorescence intensity is observed only when the fluorescent dye binds to the target, during which the hydrophobicity of the environment surrounding the dye changes. The substantial difference in emission profiles between bound and unbound dyes underlies the "light-on" mechanism.

• Staining Reagents

In EV research, accurate and efficient separation from biological samples is essential. Characterization and quantification of EVs are performed to confirm purity and consistency. Subsequently, biological activity is assessed through functional assays, and the potential for therapy is explored. Innovative products play a crucial role in this complex process.

• Staining Reagents

Innovative solution for analysis at the single particle level ★NanoFCM Flare★ 　Measurement of biological particles from 40nm 　For the production and evaluation of EVs, viruses, nucleic acid drugs, etc. ★NanoFCM Auto20★ High-throughput model equipped with auto-sampling and cleaning functions ■Capable of fluorescent detection of single molecules, phenotypes are quantified from marker intensity ■High-resolution size distribution comparable to TEM ■Measures the number concentration of all particles and fluorescently labeled particles ■Quantifies particle populations with up to two fluorescent labels

• Other physicochemical equipment
• Analytical Equipment and Devices
• Particle Counter

■One Drop & One Click Easy and Fast Measurement One drop (5μL), accurately quantifying nanoparticles in as little as 40 seconds ■Interferometric Light Microscopy Observation of Nanoparticle Measurement (ILM: Interferometric Light Microscopy) ■Measurement of unlabelled and unpurified samples ■High-precision measurement of particle size and concentration even for polydisperse samples

• Analytical Equipment and Devices
• Other physicochemical equipment
• Particle Counter

The "qEV Series" is an exosome extraction kit that can extract highly pure extracellular vesicle extracts. The "qEV Extracellular Vesicle Extraction Kit" has obtained the international standard for quality management of medical devices, ISO 13485. It allows for the separation and purification of exosomes and extracellular vesicles in just 15 minutes. The "AFC qEV Column Automatic Recovery Device" automates the process from extraction to cleaning, making the extraction of EVs much easier. 【Features】 ■ Kits can be selected based on research purposes and sample volume. ■ High-efficiency and high-precision analysis can be achieved when used with qNano. ■ Separation can be performed while maintaining the biological and morphological characteristics of EVs. ■ Improved sensitivity and accuracy for analysis and measurement. ■ Obtained the international standard for quality management of medical devices, ISO 13485. *For more details, please refer to the PDF materials or feel free to contact us.

• Separation device
• Analytical Equipment and Devices
• Other physicochemical equipment

The "AFC" is an automatic recovery device for qEV columns that simplifies the extraction process of extracellular vesicles (EVs) from extraction to cleaning. By automatically recovering fractions based on weight detection, it minimizes variability due to manual work, achieving greater reproducibility than ever before. Additionally, it features an RFID tag (an IC tag that can store information) to manage manufacturing and QA data, usage counts, and cleaning cycles. When used in conjunction with the qEV series "Extracellular Vesicle Extraction Kit" and the nanoparticle multi-analyzer "Exoid," it enables high recovery of extracellular vesicle extraction. 【Features】 ■ Fully automated extraction to cleaning, making EV extraction work easier ■ Automatic recovery of fractions based on weight detection, minimizing variability due to manual work ■ Achieves greater reproducibility than ever before * Please use qEV and AFC for basic research purposes only. They cannot be used for clinical or medical procedures. * For more details, please refer to the PDF materials or feel free to contact us.

• Separation device
• Analytical Equipment and Devices
• Other physicochemical equipment

Exoid (TRPS) enables accurate and reliable zeta potential measurements compared to other methods. 【Features】 ■ Simultaneous measurement of zeta potential and particle size for each particle ■ Unbiased results obtained through true zeta potential distribution ■ Measurement of charge at physiological strength in buffer ■ Measurement principle is the electrical resistance nanopulse method (TRPS) ■ Measurement of changes in surface charge *For more details, please refer to the materials or feel free to contact us.

• Other measurement, recording and measuring instruments