JNC List of Products and Services

"Cellufine MAX IB" is a new mixed-mode resin used for the polishing purification of monoclonal antibodies (Mab) after the purification of Protein A resin. It features surface modification with polyallylamine and the modification of some parts with butyl groups, allowing proteins to adsorb even at high salt concentrations. 【Features】 ■ Can be used for the polishing purification of antibody drugs ■ After Protein A purification, it can achieve high purity with just one purification step ■ Contributes to reduced lead times and cost savings through a two-step purification process ■ Stable resin that allows for in-place cleaning with 0.5M sodium hydroxide ■ Unique salt tolerance that retains proteins even at high salt concentrations *For more details, please refer to the PDF document or feel free to contact us.

• Chromatography

Cellufine ET Clean is a chromatography resin that immobilizes poly-ε-lysine on spherical cellulose particles. It can efficiently remove endotoxins from the target sample solution. Cellufine ET Clean can effectively remove endotoxins produced by gram-negative bacteria under conditions such as physiological saline. Since endotoxins do not elute even under high salt concentration conditions, it can be suitably used when endotoxins need to be removed from proteins. The product is available in two types: Cellufine ET Clean S: Small pores, resulting in less non-specific adsorption of proteins. Cellufine ET Clean L: Large pores, capable of adsorbing a large amount of endotoxins. 【Features】 - Adsorbs endotoxins at high salt concentrations. - At high salt concentrations where endotoxins are adsorbed, proteins pass through. - Efficiently removes endotoxins from proteins and other substances. - Stable polyamino acids do not become inactive, allowing the use of harsh cleaning solutions. *For more details, please refer to the PDF document or feel free to contact us.

• Chromatography

Cellufine Sulfate is an affinity chromatography resin used for virus purification. It has a proven track record of use in vaccine manufacturing by global pharmaceutical companies worldwide. The density gradient ultracentrifugation method used for virus purification has several drawbacks, including lead time, reproducibility, and safety issues. Cellufine Sulfate can address these shortcomings due to its chromatography capabilities. 【Features】 ■ Affinity activity for live viruses, inactivated viruses, and split viruses ■ Affinity for virus-derived antigens, bacteria-derived antigens, and heparin-binding proteins ■ The chromatography process is closed, ensuring high safety and low risk of microbial contamination ■ Effective in removing endotoxins that may have contaminated the manufacturing process, as it does not adsorb endotoxins ■ Due to its negatively charged ligands, it does not adsorb positively charged impurities such as host-derived DNA ■ Physically robust and highly durable as it is based on cellulose ■ Sterilization through multiple autoclave cycles is possible *For more details, please refer to the PDF materials or feel free to contact us.

• Chromatography

Cellufine SPA-HC is a highly reusable resin that immobilizes alkaline-resistant Protein A on porous cellulose particles, significantly improving pressure resistance through a unique crosslinking method. With proprietary particle manufacturing technology developed over 40 years of industry experience, it achieves high adsorption performance at high flow rates. Designed as a filler for actual manufacturing scales, it allows for the utilization of existing equipment while achieving reduced lead times. 【Features】 ■ Excellent dynamic binding capacity Achieves excellent dynamic adsorption even with short residence times Over 50 mg/mL excellent adsorption performance at a residence time of 2 minutes ■ High pressure resistance and liquid permeability Achieves high flow rates at low pressure through unique crosslinking technology At an operating pressure of 0.3 MPa, liquid flow is possible at a flow rate with a residence time of 2.4 minutes ■ Robust performance independent of antibody type Maintains high adsorption performance even with different monoclonal antibodies Enables robust downstream development ■ Excellent reusability Immobilizes highly alkaline-resistant recombinant Protein A Achieves excellent alkaline resistance *For more details, please refer to the PDF document or feel free to contact us.

• Chromatography

The "MC-Media Pad" is a microbial testing sheet medium that can reduce waste compared to agar media. Due to its sheet form, the amount of waste generated is approximately one-twentieth that of traditional agar plates. This helps to minimize waste generation, allowing for a reduction in costs associated with waste disposal. Our product also considers the environment through waste reduction, contributing to the achievement of the SDGs. *For more details, please refer to the catalog or feel free to contact us. ↓ Free samples are currently available! Please feel free to inquire about them ↓

• Microbiology

The "MC-Media Pad" is a microbial detection sheet medium that allows for inspections without the need for expensive equipment. The "MC-Media Pad" (formerly known as Sanita-kun) is a simplified microbial detection medium that serves as an alternative to agar media. It consists of a sheet-like medium layered with a medium for detecting target microorganisms and a water-soluble polymer non-woven fabric. This enables rapid detection as there is no need to prepare agar media. There is no need for equipment or facilities required for medium preparation, and advanced techniques for inspection are not necessary. 【Inspection Method】 Inspections can be easily and simply conducted as follows: ■ Sample Inspection You can test the microbial load in food. ■ Direct Stamp Inspection Since the surface of the medium is made of non-woven fabric, you can directly stamp it with your hands or from the production line to investigate the contamination level of the production line. ■ Settled Bacteria Inspection It is possible to test for settled bacteria, which is an indicator for managing the working environment. You can conduct the test simply by removing the film and leaving it exposed. *For more details, please refer to the catalog or feel free to contact us. ↓ Free samples are currently available! Please feel free to inquire for your request ↓

• Microbiology

"CELLUFLOW" is a porous, spherical cellulose microparticle. It has characteristics such as a smooth texture, low irritation to the skin, and water and oil absorption, making it suitable as a cosmetic ingredient. Due to its porous nature, it possesses water and oil absorption properties. By incorporating it into cosmetics such as lotions and serums, it can impart excellent texture, spreadability, and sustained release functions to the products. [Features] ■ Long-standing track record as a cosmetic ingredient ■ Solves the microplastic problem due to being plant-derived ■ Spherical particles of 10μm that penetrate pores and provide various functionalities ■ High strength both physically and chemically *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

"CELLUFLOW" is a porous, spherical cellulose microparticle. It has characteristics such as a smooth texture, low irritation to the skin, and water and oil absorption, making it suitable as a cosmetic ingredient. Due to its porous nature, it possesses water and oil absorption properties. By incorporating it into lipsticks and lip balms, products with excellent texture, spreadability, and functionality can be developed. [Features] - Proven track record as a cosmetic base material for many years - Solves the microbead issue due to its plant-based material - Exhibits good slip properties due to its spherical shape and 10μm particle size - High physical and chemical strength *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

"CELLUFLOW" is a porous, spherical cellulose microparticle. Due to its smooth texture, low irritation to the skin, and water and oil absorption properties, it is suitable as a cosmetic ingredient. Being porous, it has water and oil absorption capabilities. By incorporating it into cosmetics such as emulsions and liquid foundations, products with excellent texture, spreadability, and functionality can be developed. [Features] ■ Has a long track record as a cosmetic base material ■ Solves the microbead issue due to its plant-based composition ■ Spherical particles of 10μm that penetrate pores and provide various functionalities ■ Physically and chemically strong ■ Prevents makeup from breaking down for extended periods when formulated into foundations ■ Provides uniform application in foundations *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

"CELLUFLOW" is a porous, spherical cellulose microparticle. It has characteristics such as a smooth texture, low irritation to the skin, and water and oil absorption, making it suitable as a cosmetic ingredient. Due to its porous nature, it possesses water and oil absorption properties. By incorporating it into cosmetics such as foundation, eye color, and body powder, products with excellent texture, spreadability, and functionality can be developed. [Features] - Proven track record as a cosmetic base material for many years - Solves the microbead issue due to its plant-based material - Spherical particles of 10μm that penetrate pores and provide various functionalities - High strength both physically and chemically - Prevents makeup from breaking down for extended periods when formulated in foundation - Provides uniform application in foundation *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

"CELLUFLOW" is a porous, spherical cellulose microparticle. It has characteristics such as a smooth texture, low irritation to the skin, and water and oil absorption, making it suitable as a cosmetic ingredient. Due to its porous nature, it possesses water and oil absorption properties. By incorporating it into cosmetics such as foundation and sunscreen, products with excellent texture, spreadability, and functionality can be developed. [Features] - Proven track record as a cosmetic base material for many years - Solves the microbead problem due to its plant-based material - Spherical particles of 10μm that penetrate pores and provide various functionalities - High strength both physically and chemically - Prevents makeup from breaking down for extended periods when formulated into foundation - Provides uniform application properties to foundation *For more details, please refer to the PDF document or feel free to contact us.

• Cosmetic materials and raw materials

"Cellufine" is a resin to chromatography used for the purification of antibody drugs such as monoclonal antibodies, biopharmaceuticals like proteins and enzymes, vaccines, virus particles, and food additives. Due to its spherical cellulose particles, it has mechanical strength and high biocompatibility, making it widely used for the purification of biopharmaceuticals. With over 40 years of manufacturing experience, it has been adopted by global pharmaceutical companies around the world. Additionally, as it is derived from natural polysaccharides, it has a lower level of leachables compared to synthetic polymers. 【Features】 - Adopted by pharmaceutical companies worldwide for the purification of biopharmaceuticals - Can be operated at high flow rates - High adsorption performance allows for cost improvements in the manufacturing process - Lower leachables compared to synthetic polymers due to being made from natural polysaccharides - Manufactured under an ISO9001 quality system *For more details, please refer to the PDF document or feel free to contact us.

• Chromatography

The "MC-Media Pad" (formerly known as Sanita-kun) is a simplified microbial detection medium that serves as an alternative to agar media. It consists of a sheet-like medium layered with a medium for detecting target microorganisms and a water-soluble polymer non-woven fabric. Since there is no need to prepare agar media, rapid detection is achieved. Testing can be conducted without high levels of expertise or expensive equipment, allowing for inspections to be performed anytime and anywhere. Additionally, due to the optimization of microbial detection technology, the cultivation time is shorter compared to traditional agar media, enabling faster detection. This product is certified by international certifications such as AOAC-PTM, AOAC-OMA, and MicroVal, and is included in the food hygiene inspection guidelines, which are considered the standard for food microbial testing in Japan, ensuring safe usage. 【Features】 ■ Easy to use as it spreads naturally with a pipette ■ Medium optimized for good bacterial coloration ■ Contributes to reduced cultivation time ■ Different color tapes for each microorganism help minimize operator errors ■ Achieves simple microbial testing compliant with HACCP *For more details, please download the PDF or feel free to contact us.

• Microbiology