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In the pharmaceutical industry, cleaning validation and product changeover are essential processes to ensure product quality and safety. In particular, the use of at-line TOC measurement based on PAT is very useful. - PAT Guidance Introduced in 2004, PAT guidance is an innovative framework for drug development, manufacturing, and quality assurance. This guidance provides a scientific, risk-based approach and promotes innovation and efficiency improvements by the industry and regulatory agencies. The PAT guidance introduces the "at-line" method, which involves sampling and measurement close to the process. By using the Sievers M9 portable TOC meter, it becomes possible to test rinse samples and swab samples for cleaning validation and product changeover at-line.

In the pharmaceutical industry, cleaning validation and product changeover are essential processes to ensure product quality and safety. However, traditional laboratory sample analysis is time-consuming and costly, leading to delays in production schedules. Therefore, the introduction of at-line TOC measurement is gaining attention. - Benefits of Introducing Portable TOC Meters The Sievers M9 portable TOC meter provides measurement results that are equal to or better than those obtained in the lab. The manufacturing team can perform sampling and measurement on-site and quickly document the results, eliminating the need for the quality control team to report results and wait for equipment approval. By implementing at-line TOC methods, annual sampling costs can be significantly reduced.

Sievers brand TOC analyzers, standard solutions, and consumables have been used by users around the world for over 30 years. Recognized as a global leader in TOC measurement technology, Sievers provides the highest quality standard solutions and consumables through expertise and Six Sigma methods. The pre-prepared standard solutions are designed for applications such as calibration, verification, and system suitability, and can also be used with TOC analyzers from other manufacturers. Additionally, we offer TOC vials with a cleaning guarantee of less than 10 ppb and cleaning validation kits.

● No calibration required, reagent-free measurement ● Ultra-low maintenance design with air cleaning + ultrasonic cleaning method

●Measurement of organic substances that cannot be detected by UV ●Higher sensitivity than differential refractive index detector (RI) The Sievers TOC Analyzer M9 SEC is a detector for organic substances separated by molecular weight using a GPC/SEC system. It is capable of measuring organic substances that do not absorb UV light (such as alcohols and polysaccharides) with higher sensitivity than a differential refractive index detector (RI). Application examples: Measurement of refractory organic substances in environmental water, optimization of membrane treatment for wastewater, management of activated carbon injection amounts, measurement of precursor substances for disinfection by-products, quality control of pharmaceuticals, cosmetics, and plastics.

In the pharmaceutical industry, processes that are free of waste and continuous improvement are required. Efficient processes enable the provision of safe and high-quality pharmaceuticals when needed. By adopting real-time testing of pharmaceutical water, it is possible to streamline the manufacturing process while ensuring quality. At Central Science, real-time testing of TOC and conductivity using the Sievers TOC analyzer optimizes the monitoring of pharmaceutical water systems, achieving better process control, productivity improvement, and risk management for cGMP processes. **Features** - Reduces costs, resources, contamination, lab errors, and data delays associated with traditional lab analysis - Detects and addresses OOS and OOT in real-time - Continuous control and system validation - Setting of alert levels and action levels based on trend data In the PDF data, you can find technical materials related to TOC real-time testing and information on the "Online TOC Analyzer Sievers M500" and "Sievers M9 Lab Model for Pharmaceutical Water/Cleaning Validation." *For more details, please download the catalog or contact us directly.*

The Sievers M5310C is an online TOC analyzer that supports continuous automatic TOC measurement in accordance with the Ministry of the Environment's notification [Appendix Table 30-2]. It automates and streamlines water quality management at water treatment plants, enabling anomaly detection and rapid response. **Features** - Compliance with regulations: Adheres to continuous automatic measurement methods based on drinking water quality standards - High-precision measurement: Achieves accuracy equivalent to laboratory models - Real-time measurement: Measurement interval of 2 minutes, no carrier gas required - Labor-saving: Significantly reduces human burden with automatic sampling - Dual-channel model support: Simultaneously measures raw water and treated water with a single unit

The TOC analyzer Sievers M5310C model complies with the water quality testing method notification, achieving real-time, high-precision TOC measurements. It eliminates the need for carrier gas, reducing running costs, and allows for immediate measurement upon power-on. An online model is also available that can simultaneously monitor raw and treated water with a rapid 2-minute cycle. 【Features】 Compliance: Adheres to the ministerial ordinance regarding water quality standards Rapid Measurement: No warm-up required, 2-minute cycle No Carrier Gas Required: Low-cost operation High Precision: Stable measurements even at low concentrations below 0.3 mg/L Three Models Available: Lab type / Online type / Portable type

In the semiconductor industry, the quality control of ultra-pure water (UPW) in the manufacturing process is a crucial factor that affects product yield and quality. In particular, the contamination of trace amounts of TOC (total organic carbon) and boron can adversely impact the performance of semiconductor devices. Our water quality monitoring equipment continuously monitors these trace components with high precision, maintaining the quality of the UPW system. [Application Scenarios] - UPW systems in semiconductor manufacturing plants - Each process, including raw water, RO water, reclaimed water, UF/EDI, and use points [Benefits of Implementation] - Stabilizes the quality of UPW, contributing to improved yield - Reduces the risk of product defects caused by TOC and boron - Enhances manufacturing process efficiency and reduces costs

We will be exhibiting at CPHI Japan 2026 (International Pharmaceutical Development Exhibition)! 【Exhibition Details】 ■Exhibition Name: CPHI Japan 2026 ■Venue: Tokyo Big Sight, East Hall 3 ■Booth Location: Equipment and Machinery Zone 3G-37 ■Admission Fee: Free (Pre-registration required) We sincerely look forward to your visit.

【 Sievers M9 】This TOC analyzer, with its unique gas-permeable membrane conductivity measurement method and wide measurement range, can accommodate various applications. - No carrier gas required - Stability in ultra-low concentration ranges - 12 months of calibration stability - Compliance with data integrity requirements based on 21 CFR Part 11 (optional) 【 Sievers Soleil 】This rapid analysis device detects fewer than 10 viable bacteria in 100 mL with ultra-high purity within 45 minutes. - Assists in rapid decision-making: Quality control of pharmaceutical water / Cleaning validation 【 Sievers Eclipse 】This endotoxin meter is designed for easy endotoxin measurement by anyone. - Semi-automated measurement with dedicated microplates and microfluidic technology - Less than 30 pipetting operations, significantly reducing preparation time and effort (21 samples) - Reduced usage of lysate reagents 【 Sievers M500 】This third-generation online TOC analyzer has evolved from reagent-free gas-permeable membrane conductivity measurement technology. - Real-time measurement at 3-minute intervals - Compliance with data integrity based on 21 CFR Part 11

In the field of agriculture, particularly in irrigation, water quality significantly affects crop growth. High organic matter concentration in irrigation water can lead to reduced soil permeability and increased risk of pests and diseases. The Sievers InnovOx TOC analyzer measures total organic carbon (TOC) with high reliability, even in irrigation water containing high salinity and turbidity, using supercritical water oxidation (SCWO) technology. This allows for accurate assessment of irrigation water quality and enables appropriate water quality management. 【Use Cases】 - Water quality monitoring of irrigation water - Water quality management in the reuse of treated wastewater - Evaluation of the impact of fertilizer components 【Benefits of Implementation】 - Increased yield due to improved irrigation water quality - Reduced risk of pests and diseases - Optimization of fertilizer costs

In the food industry, monitoring water quality in process management is crucial. Particularly, to ensure food safety and quality, it is necessary to quickly and accurately detect the presence of organic substances. Even in wastewater containing high salt concentrations and turbidity, which have been difficult to measure with conventional methods, the Sievers InnovOx achieves complete oxidation through supercritical water oxidation (SCWO) technology, enabling accurate TOC measurement. 【Application Scenarios】 - Wastewater management in food manufacturing processes - Quality control of cleaning water - Quality control of products 【Benefits of Implementation】 - Improved accuracy of water quality monitoring in process management - Stabilization of product quality - Compliance with regulations

In the beverage industry, managing water quality during the manufacturing process is essential for maintaining product safety and quality. In particular, TOC (Total Organic Carbon) is important as an indicator of organic contamination in water, which can affect the flavor and shelf life of the product. The Sievers InnovOx TOC analyzer enhances water quality management in beverage manufacturing through high-precision TOC measurements, contributing to improved product quality. 【Use Cases】 - TOC monitoring of process water and cleaning water - Quality inspection of products - Optimization of manufacturing processes 【Benefits of Implementation】 - Stabilization of product quality - Increased efficiency of manufacturing processes - Compliance with regulations

In wastewater analysis within the chemical industry, accurate measurement of diverse organic compounds is required. In particular, wastewater containing high salinity or insoluble organic matter can be difficult to measure with conventional TOC analyzers. Inaccurate measurements can hinder the optimization of wastewater treatment processes and compliance with environmental regulations. The Sievers InnovOx TOC analyzer addresses these challenges through supercritical water oxidation (SCWO) technology, providing reliable data. 【Application Scenarios】 - Wastewater management in chemical plants - Wastewater analysis in research institutions - Wastewater monitoring in environmental surveys 【Benefits of Implementation】 - Capability to handle a wide range of samples through high-concentration TOC measurement - Improved data accuracy due to high reliability and stability - Enhanced analytical efficiency through conversion functions from TOC to BOD and COD

In the oil industry, accurate measurement of organic matter in water is required to suppress equipment corrosion. In particular, organic matter in process water can be a cause of corrosion, making its management crucial. The Sievers InnovOx TOC analyzer can accurately measure samples containing brine (high salinity water) and suspended or insoluble organic matter, contributing to the reduction of corrosion risk. 【Application Scenarios】 - Measurement of organic matter in boiler water - Management of organic matter in process water - Monitoring for corrosion suppression 【Benefits of Implementation】 - Early detection of corrosion risks - Stable operation of plants - Cost reduction

In the power generation industry, accurate monitoring of water quality contaminants is essential for boiler water management. Particularly, precise measurement of organic matter is crucial for the efficient operation of boilers and the protection of equipment. Inadequate water quality management can lead to decreased boiler efficiency, corrosion, and scale buildup, potentially shortening the lifespan of the equipment. The Sievers InnovOx TOC analyzer accurately measures TOC in boiler water, including high-salinity water and insoluble organic matter, using supercritical water oxidation technology, thereby supporting stable boiler operation. 【Application Scenarios】 - TOC measurement of boiler water - Prevention of foreign matter contamination in turbines - Monitoring of water treatment processes 【Benefits of Implementation】 - Efficient operation of boilers - Protection and longevity of equipment - Optimization of water quality management

In the field of environmental pollution investigation, it is important to accurately grasp organic contamination of soil and water quality. In particular, complex samples containing high salinity or insoluble organic matter may pose challenges for accurate analysis using conventional measurement methods. The Sievers InnovOx TOC analyzer achieves complete oxidation of such special samples through supercritical water oxidation (SCWO) technology, providing reliable data. 【Application Scenarios】 - Water quality pollution investigation of rivers, lakes, and groundwater - Organic matter analysis in soil contamination investigations - Monitoring of wastewater treatment facilities 【Benefits of Implementation】 - Accurate understanding of contamination conditions through high-precision TOC measurements - Improved analysis efficiency by accommodating a wide range of samples - Support for decision-making through enhanced reliability of measurement data

In the water treatment industry, water quality management is a critical issue in water recycling. In particular, accurately understanding the concentration of organic matter in reused water is essential for maintaining safe water quality and establishing efficient water treatment processes. Traditional measurement methods have faced challenges in measuring samples that contain high salinity or turbidity. The Sievers InnovOx addresses these challenges and improves the reliability of TOC measurements in water reuse. 【Application Scenarios】 - Water quality management of reused water in wastewater treatment plants - Measurement of organic matter concentration in industrial water recycling - Water quality analysis in research institutions 【Benefits of Implementation】 - Optimization of water quality management through high-precision TOC measurements - Improved measurement efficiency by accommodating a wide range of samples - Enhanced reliability through stable measurement results

In research fields, the accuracy and reproducibility of experiments are crucial. Particularly in water quality analysis, sample pretreatment significantly affects measurement results. Samples that are difficult to measure using conventional methods, such as those containing high salinity or turbidity, can hinder accurate TOC measurements. The Sievers InnovOx addresses these challenges through supercritical water oxidation (SCWO) technology, enhancing data reliability in research. 【Application Scenarios】 - Water quality analysis in environmental research - Reaction monitoring in chemical research - Culture medium analysis in biotechnology research 【Benefits of Implementation】 - Increased research efficiency through the ability to handle a wide range of samples - Improved data accuracy due to high reliability and stability - Diversification of analysis through TOC to BOD and COD conversion functions

In the petrochemical industry, particularly in refineries, strict management of water quality and quantity is essential for efficient operations. Delays in water quality management increase the risk of cost increases and regulatory violations. Rapid decision-making using real-time data contributes to cost and time savings, as well as water reuse and recycling. Our water quality measurement devices have been developed to address these challenges. 【Use Cases】 - Management of water quality for cooling water, boiler feed water, and other process water - Management and minimization of water usage - Compliance with wastewater standards - Improvement of process control 【Benefits of Implementation】 - Cost reduction - Compliance adherence - Enhanced sustainability of the plant

In the power industry, efficient operation of plants is essential for stable power supply. Water is used for various purposes such as cooling and boilers, and its quality management directly impacts the stable operation of the plant. Deterioration of water quality can lead to equipment failure and decreased efficiency, potentially resulting in instability in power supply. Our water quality measurement devices contribute to the stable operation of plants by providing real-time data and supporting quick decision-making. 【Application Scenarios】 - Water quality management for cooling water and boiler feedwater - Optimization of water treatment processes - Detection of abnormalities in the plant 【Benefits of Implementation】 - Stable operation of the plant - Cost reduction - Compliance with regulations

In the food industry, managing the quality of water used in manufacturing is crucial to ensure product quality and safety. Water quality directly affects the taste, safety, and shelf life of products, necessitating strict management. Water pollution can increase the risk of product quality deterioration and foodborne illnesses. Our real-time data-driven water quality monitoring system enables rapid anomaly detection and response, contributing to the maintenance of food quality. 【Use Cases】 - Water quality management in food manufacturing - Preservation of product quality - Optimization of manufacturing processes 【Benefits of Implementation】 - Thorough quality management - Improved product safety - Reduction in manufacturing costs

In the pulp industry, wastewater treatment requires compliance with discharge standards and optimization of the treatment process. It is particularly important to accurately understand the concentration of organic matter in the wastewater and efficiently remove it. Inadequate water quality management can increase the environmental burden and raise the risk of compliance violations. Our real-time water quality monitoring system rapidly and accurately measures TOC (Total Organic Carbon) to support the optimization of the wastewater treatment process. [Usage Scenarios] - Monitoring of the wastewater treatment process - Compliance with discharge standards - Improvement of treatment efficiency [Benefits of Implementation] - Real-time understanding of organic matter concentration in wastewater - Early detection of abnormalities in the treatment process - Reduction of wastewater treatment costs

In the metal industry, suppressing corrosion is a crucial issue for maintaining product quality and extending the lifespan of equipment. In particular, water quality management used in the manufacturing process significantly affects the occurrence of corrosion. Impurities in the water can promote metal corrosion, potentially leading to product defects and early deterioration of equipment. Our water quality monitoring system enables rapid responses based on real-time data, reducing the risk of corrosion. 【Usage Scenarios】 - Cooling water management in metal processing - Water quality management in cleaning processes - Optimization of wastewater treatment processes 【Benefits of Implementation】 - Reduction of product defects due to corrosion - Decrease in equipment maintenance costs - Improvement in product quality

This is a pre-cleaned TOC vial specifically designed for TOC analysis. It comes with a cleaning guarantee of less than 10 ppb TOC, which helps minimize contamination from the container and ensures stable TOC measurements. It is compatible with TOC analyzers from various manufacturers, including Sievers. The vial itself is reusable, and only the cap needs to be replaced, contributing to reduced running costs. **Features:** - Cleaning guarantee of less than 10 ppb TOC: Since it is pre-cleaned, it reduces the risk of blank increases and sudden abnormal values from the vial. - Reusable vial for cost reduction: Only the cap can be replaced. The vial can be used repeatedly, helping to control consumable costs. - Thin septum adopted: Reduces the burden on the needle due to septum degradation, lowering the risk of equipment troubles. - Usable with TOC analyzers other than Sievers: Compatible with a wide range of TOC analyzers regardless of the manufacturer. - Packaging considerate of pharmaceutical manufacturing areas: Uses a plastic corrugated case (to prevent cardboard powder) to accommodate clean environments.