ナード研究所 List of Products and Services

Microwaves are a type of electromagnetic wave, and when microwaves are irradiated, they are absorbed by a substance depending on its dielectric properties, causing the substance itself to heat up. This phenomenon is utilized as a new heat source for organic synthesis reactions. Due to the wide variety of applicable reactions, our company conducts various reactions using microwave synthesis equipment. **Effects of Microwaves** - Reduction of reaction time, suppression of side reactions, and improvement of yields are possible. - Since it acts directly on the substance, it allows for solvent-free reactions, uniform heating in solid-phase reactions, and promotes reactions. - The ability to conduct reactions at temperatures higher than the boiling point leads to effects such as improved solubility. - Microwave-specific effects such as positional selectivity, stereoselectivity, and high crystallization. *For more details, please refer to the related link page or feel free to contact us.*

Our company has both batch and flow-type photoreaction devices, allowing us to carry out reactions using the most suitable methods. In the past, we have developed flow-type photoreactions for the synthesis of phenazines, achieving shorter reaction times and improved yields compared to batch methods. Based on these results, we propose improvements for effective synthesis by selecting appropriate techniques tailored to the characteristics of photoreactions. 【Features】 ■ Equipped with both batch and flow-type photoreaction devices ■ Capable of conducting reactions using suitable methods ■ Reduction in reaction time and improvement in yield compared to batch methods ■ Selection of appropriate techniques based on the characteristics of photoreactions ■ Proposals for improvements towards effective synthesis *For more details, please refer to the related links page or feel free to contact us.

In recent years, we support continuous process development using microreactors and multi-stage continuous stirred-tank reactors (multi-stage CSTR) in the increasingly recognized field of flow synthesis. We can accommodate flash chemistry, avoidance of ultra-low temperature reactions, high-temperature reactions, high-pressure reactions, heterogeneous reactions, gas-liquid, solid-liquid, and gas-solid-liquid reactions, demonstrating effectiveness in precise reaction control, utilization of unstable intermediates, improved safety, and one-pot synthesis. Additionally, we can handle the difficult management of slurries and continuous crystallization in continuous processes. 【Features】 ■ Capable of accommodating flash chemistry (ultra-fast reactions), avoidance of ultra-low temperature reactions, high-temperature reactions, high-pressure reactions, heterogeneous reactions, gas-liquid, solid-liquid, and gas-solid-liquid reactions ■ Effective in precise reaction control, utilization of unstable intermediates, and improved safety ■ Able to handle the difficult management of slurries and continuous crystallization in continuous processes *For more details, please refer to the related link page or feel free to contact us.

With the advancement of medicine and the aging population, there is a growing demand for improved health and quality of life, which is creating new needs for pharmaceutical development. Drugs that show effects in extremely small amounts can also pose a high risk of health hazards in the development and manufacturing processes. Our company has been operating containment facilities since April 2016 with the aim of safely and securely handling these substances. Leveraging our long-standing expertise in organic synthesis and this facility, we provide safe and secure contract synthesis and purification services for highly pharmacologically active compounds, contributing to the acceleration of development in this field. 【Facility Overview】 ■ Manufacturing Room: 17m² (2 Hazard Rooms) and DG Room / Pass Box ■ Containment Equipment: Hazard Room / Safety Cabinet / Draft Chamber ■ Static Pressure Management: -15Pa to -30Pa ■ Manufacturing Environment / External Environment: Class 100,000 HEPA performance / HEPA exhaust *For more details, please refer to the related link page or feel free to contact us.