ナード研究所 List of Products and Services

Nerd Research Institute's contract manufacturing collaborates with its 100% subsidiary, Nerd Chemicals Co., Ltd., to meet a wide range of requests from initial prototype manufacturing in the early stages of development to product manufacturing. Nerd Chemicals prides itself on a high-quality assurance system and flexible responses, adapting to the provision of products in various fields. Among its strengths, it excels in process development for industrialization, with a research and development team specializing in process examination that aims to establish safe and reliable manufacturing methods that meet the required specifications of customers. [Nerd Chemicals' Features] ■ Skilled in small-batch, multi-product manufacturing ■ High technical level of each employee ■ Quality assurance system that meets expectations (GMP standards, ISO 9001) *For more details, please download the PDF or feel free to contact us.

• Contract manufacturing

We would like to introduce our "Flow Synthesis Service." With years of experience, we provide support for flow synthesis. We can quickly facilitate the transition from batch synthesis to flow synthesis. Please feel free to contact us when you need assistance. 【Features of Our Contract Synthesis】 ■ No synthesis data? No problem! We can propose synthesis methods for new compounds. ■ Our researchers engage in direct dialogue, smoothly reflecting your requests in planning and results. ■ We work together with customers to think of solutions to research challenges. *For more details, please download the PDF or feel free to contact us.

• Processing Contract

We would like to introduce our "Synthesis of Inorganic Compounds." We conduct the synthesis of nanoparticle-supported catalysts, raw material mixing using a planetary ball mill, and investigations into the sublimation purification of inorganic compounds. Please feel free to contact us when you need our services. 【Features of Our Contract Synthesis】 ■ No synthesis data? No problem; we can propose synthesis methods for new compounds. ■ Researchers engage in direct dialogue to smoothly reflect your requests in planning and results. ■ We work together with customers to think of solutions to research challenges. *For more details, please download the PDF or feel free to contact us.

• Processing Contract

We would like to introduce our company's "Synthesis of Polymer Processing Materials." We carry out the synthesis of terminal functionalized polymers using chain transfer agents, the synthesis of polybutadiene through anionic polymerization, and the introduction of functional group terminals using chain transfer agents. Please feel free to contact us when you need our services. 【Features of Our Contract Synthesis】 ■ No need for synthesis data; we can propose synthesis methods even for new compounds. ■ Researchers engage in direct dialogue to smoothly reflect your requests in planning and results. ■ We work together with customers to think of solutions for research challenges. *For more details, please download the PDF or feel free to contact us.

• Processing Contract

Nerd Research Institute offers low metalization services for customers who wish to explore low metalization options. When it comes to low metalization of organic materials, it is necessary to consider synthetic methods using metal-free containers and equipment, purification methods for the removal of metal elements, and analytical methods regarding the stability and reproducibility of analyses. Our company streamlines research and development with our low metalization process development services. 【Features of Our Contract Synthesis】 ■ No need for synthesis data; we can propose synthesis methods even for new compounds. ■ Researchers engage in direct dialogue to smoothly reflect your requests in planning and results. ■ We work together with customers to think of solutions for research challenges. *For more details, please download the PDF or feel free to contact us.

• Processing Contract

We would like to introduce our "Synthesis of Organic Compounds." We deliver over 1,000 compounds annually and have a proven track record in most organic reactions. We can propose syntheses even for compounds that have not been reported in literature or patents. Please feel free to contact us when you need assistance. 【Refining Techniques】 ■ Recrystallization ■ Distillation ■ Chromatography ■ Sublimation purification ■ Clean environment *For more details, please download the PDF or feel free to contact us.

• Processing Contract

Nard Laboratory Co., Ltd. is a contract research and manufacturing company specializing in research and development with many years of proven experience. We solve the challenges faced by researchers dealing with compounds, such as the inability to obtain necessary reagents, lack of knowledge about synthesis methods, the need for larger quantities of higher purity reagents, and the desire to consult with chemistry experts. Our company has a Life Sciences Research Division, a Materials Science Research Division, and a Corporate Research Division. [Business Activities] ■ Support for drug discovery research and synthesis ■ Custom synthesis of functional molecules *For more details, please download the PDF or feel free to contact us.

• Contract manufacturing

Thio-tag is a mononuclear zinc complex molecule developed at Hiroshima University Graduate School of Biomedical and Health Sciences, Department of Pharmaceutical Molecular Functional Chemistry, designed to capture thiol compounds. "Thio-tag Chloride" can protect SH-containing compounds such as cysteine thiol groups under physiological pH, room temperature, and air atmosphere, and can be used as a selective stabilizer for analysis. It can be easily dissociated under acidic conditions at pH 3 or through EDTA treatment. Additionally, we also offer "Thio-tag Tip," which allows for the separation and purification of thiol compounds at physiological pH. 【Product Lineup】 ■ Thiol Stabilization Buffer: Thio-tag Chloride ■ Thiol Affinity Chromatography: Thio-tag Tip *For more details, please refer to the related link page or feel free to contact us.

• Other polymer materials

It is a benzylation reaction of hydroxyl groups under basic conditions. For substrates where the Williamson ether synthesis method cannot be applied, benzylation reactions under neutral or acidic conditions are effective. We offer a lineup of benzylating agents that can be used under neutral or acidic conditions. Additionally, we also accept contract manufacturing using such special benzylating agents, so please feel free to consult us. 【Lineup】 ■TriBOT ■TriBOT-PM ■DPT-BM *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• Contract manufacturing
• Chemicals

Nard Institute was founded in 1972 starting from contract research business and began custom synthesis of PET reagents in 1995. For PET reagents, we have a wealth of synthesis achievements for numerous precursors and reference materials. Our company offers a wide range of products, available for sale with a purity of 98% (or 95%) or higher, starting from a minimum quantity of 10mg. We provide short delivery times and will attach HPLC charts with results. Product information is constantly updated, so please feel free to consult us. 【Features】 ■ Custom synthesis for reagents not listed in the catalog ■ Extensive manufacturing experience compliant with GMP ■ Manufacturing support from our subsidiary Nard Chemicals, which has a quality assurance system based on GMP standards ■ Design of compound structures suitable for PET probes and synthesis of derivatives to support early development of PET probes *For more details, please refer to the related links page or feel free to contact us.

• Other contract services

The "Phos-tag technology" is a groundbreaking method for the separation, purification, and detection of phosphorylated substances using Phos-tag. Phos-tag is a functional molecule developed by the Laboratory of Pharmaceutical Molecular Function Science at Hiroshima University, which captures phosphate monoester anions (R-OPO32-) at neutral pH (physiological pH). Our company offers contract analysis using Phos-tag SDS-PAGE, providing strong support for research on protein phosphorylation. Additionally, we synthesize special Phos-tag compounds that have undergone chemical modifications such as various labeling, immobilization to single entities, and amino acid introduction. 【Features of Phos-tag SDS-PAGE】 ■ Enables analysis of substrate protein phosphorylation by kinases ■ Quantitatively visualizes phosphorylated and non-phosphorylated substrates ■ Analyzes the phosphorylation state of proteins within cells ■ Allows for Western blot analysis of target proteins ■ Bands can be excised from the gel after staining for mass spectrometry analysis *For more details, please refer to the related link page or feel free to contact us.

• Contract Analysis
• Other contract services

Betaine is a compound with a structure where three alkyl chains are attached to the amino group of an amino acid, possessing both positive and negative charges within the molecule. The alkyl chain portion is hydrophobic, while the zwitterionic part is hydrophilic. "Betaine 5" utilizes the properties of this betaine to enable the high-concentration solubilization of poorly water-soluble dyes. This technology is expected to allow for more precise detection when used in staining techniques such as ELISA. For inquiries regarding product and technology information, please feel free to contact us. 【Features】 ■ Contains both positive and negative charges within the molecule ■ The alkyl chain portion is hydrophobic, while the zwitterionic part is hydrophilic ■ Capable of high-concentration solubilization of poorly water-soluble dyes *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• others

Ionic liquids have unique properties due to their structural characteristics, such as having almost no vapor pressure, being non-flammable and non-combustible, and having high thermal stability. They are expected to be applied in various uses beyond just solvents. Our company has a track record of synthesizing over 100 types of ionic liquids, ranging from commercially available ones like [BMIM][PF6] to various custom-synthesized ionic liquids that are not listed in reagent catalogs. Moreover, due to their unique properties, ionic liquids are anticipated to be applied not only as new reaction solvents and extraction solvents but also in various fields such as battery materials. Our company has a diverse synthesis record of ionic liquids through methods such as synthesis using autoclaves and anion exchange reactions. 【Features】 ■ Track record of synthesizing over 100 types of ionic liquids ■ Custom synthesis of various ionic liquids *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• others

At Nard Laboratory Co., Ltd., we offer contract synthesis services for OLED materials (organic EL) that are attracting attention as next-generation displays, excelling in visibility, responsiveness, and energy efficiency. We have a proven track record of synthesizing over several hundred compounds, including metal complexes represented by Alq3, aromatic amine-based materials such as TPD and NPD, phosphorescent materials represented by Ir(ppy)3, and recently popular TADF materials. We can supply synthesis quantities ranging from a few grams to kilograms across various scales. For compounds with unknown synthesis routes, if you provide the structure, we will propose a synthesis route from our side. [Features] - Proven track record of synthesizing over several hundred compounds - If you provide the structure, we will propose a synthesis route - We can also accept research in the form of a fixed period for exploring synthesis routes for new compounds or improving manufacturing processes *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• Organic Natural Materials
• Organic EL

"Organic solar cells" utilize inexpensive materials and have an easy manufacturing process, which is expected to significantly reduce costs compared to silicon solar cells, making them the next generation of solar cells. There are two strong candidates: "dye-sensitized solar cells" and "organic thin-film solar cells," both of which are being promoted by the NARD Institute. "Organic thin-film solar cells" use organic semiconductors such as fullerene and phthalocyanine, and high purity of the compounds is required. Our company conducts the synthesis and purification of dyes based on our extensive knowledge and experience in organic synthesis, and we can also propose synthetic routes for newly designed materials for solar cells. [Features] ■ Synthesis and purification of dyes based on extensive knowledge and experience in organic synthesis ■ Proposals for synthetic routes for newly designed materials for solar cells *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• others

Organic semiconductors refer to organic materials that exhibit semiconductor properties, with applications expected in field-effect transistors and organic solar cells. At Nard Research Institute, we manufacture and sell high-purity organic semiconductors such as picene using our own sublimation purification equipment. We cater to everything from research sample sales to industrial production, and we offer custom solutions for purity enhancement and additional analysis. Additionally, we produce high-purity organic semiconductors with a purity of over 99.9% using our own sublimation purification equipment. We accommodate everything from research sample sales to industrial production. 【Features】 - Manufacture and sale of high-purity organic semiconductors such as picene - Support from research sample sales to industrial production - Custom solutions available for purity enhancement and additional analysis *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• Other semiconductors
• others

To achieve miniaturization of lenses, it may be necessary to start from the design of the monomers that serve as materials. At Nard Research Institute, we have a track record of synthesizing various acrylic and methacrylic monomers, as well as coating agents like polyamic acid, using the synthetic techniques we have developed so far. Even for compounds with unknown synthetic routes, if you provide the structure, we can assist from the exploration of the synthetic route to the establishment of the manufacturing process. Additionally, our company has experience in synthesizing various acrylic and methacrylic monomers, as well as coating agents such as polyamic acid, not just low molecular weight monomers. [Features] ■ If you provide the structure, we can assist from the exploration of the synthetic route to the establishment of the manufacturing process. *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• Coating Agent
• others

Nard Laboratory Co., Ltd. supports the research and development of polymer materials used in environments that come into contact with biological cells such as skin and blood. The development of biocompatible materials is attracting significant attention in the fields of medical devices and regenerative medicine research and development. Surface properties act on the contacting cells, influencing cell adhesion promotion or inhibition, and even the secretion of growth factors due to extracellular stimuli. Our company examines the development of these materials from a biochemical perspective to contribute to our customers' research and development. 【Features】 ■ Prototype development of polymers for coating surfaces of devices and equipment ■ Support for the development of biodegradable polymers ■ Fluorescent labeling of polymer materials and functional molecular labeling (biochemical research reagents) ■ Process development for medical polymers ■ Chemical modification of reactive functional groups on polymers ■ Hydrogel modification *For more details, please refer to the related links page or feel free to contact us.

• Other contract services
• Other polymer materials
• others

Nard Laboratory Co., Ltd. has been involved in the development and commercialization of flame-retardant sheets and heat-resistant ducts in collaboration with product processing companies. The specific flame-retardant properties are achieved by coating with a flame-retardant paint developed by blending inorganic materials based on silicone resin. We also have a track record of developing insulation materials that have been made flame-retardant through bonding with insulating materials. In this way, by providing the flame-retardant technologies we have cultivated so far, we can assist in the examination of flame-retardancy improvements and non-combustibility considerations. 【Features】 ■ Engaged in the development and improvement of protective coatings ■ Possesses a track record in the development of flame-retardant insulation materials ■ Provides assistance in examining flame-retardancy improvements and non-combustibility considerations ■ Holds expertise in chemical synthesis technology ■ Capable of assisting in the synthesis and development of new flame retardants *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• others

Our company offers a wide range of services tailored to customer needs, from early-stage research and small-scale sample synthesis to scale-up considerations and manufacturing. We cover a broad spectrum of fields, from general materials to new materials such as electronic materials. In the area of inorganic compounds, we have a track record in battery and electronic materials, metal nanoparticles, ceramic and carbon materials, and in composite materials, we have experience with radiation dose indicators and various special coatings. 【Features】 ■ Organic reactions: General organic synthesis ■ Polymer reactions: Radical polymerization, ionic polymerization, electrochemical polymerization, condensation, etc. ■ Modification and blending of polymers: Grafting reactions, oxidation reactions, reduction reactions ■ Synthesis and preparation of inorganic compounds: Sol-gel reactions, hydrothermal synthesis ■ Processing: Sintering, calcination, etc. ■ Compositing: Mixing, dispersion, coating *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• others

Nard Research Institute Co., Ltd. has a rich track record in the synthesis of various compounds, including pharmaceuticals, pesticides, other natural products, and biomolecules (nucleic acids, glycosides, phosphoric esters). We accommodate various organic synthesis reactions, such as low-temperature reactions, anhydrous reactions, ozonolysis, photochemical reactions, and asymmetric synthesis. Even in cases where there is no established synthetic route, we will propose suitable routes by combining new literature database searches with our extensive experience. [Features] - Rich synthesis track record of various compounds - Support for various organic synthesis reactions - Proposal of suitable routes based on our extensive experience *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• others

In recent years, materials for material science applications, particularly resist materials and materials for organic electronics, are required not only to be of high purity but also to have reduced metal content. Nard Research Institute utilizes various purification technologies, including sublimation purification developed over more than 40 years of experience, to achieve the reduction of each metal component (from ppm to ppb) and meet customer demands. For inquiries or questions regarding product and technology information, please feel free to contact us. 【Features】 ■ Achieves reduction of each metal component (from ppm to ppb) using various purification technologies. *For more details, please refer to the related link page or feel free to contact us.

• others
• Other contract services
• Other metal materials

At the Nard Research Institute, we have been advancing the acquisition of manufacturing technologies and the expansion of separation and purification techniques and equipment in cutting-edge fields such as pharmaceuticals, electronic materials, automotive materials, and bio-related materials. Utilizing all the technologies and equipment we have cultivated so far, we not only support HPLC separation using silica gel, ODS, and GPC columns but also HPLC separation of optically active compounds using chiral columns. Additionally, we possess a mass-triggered HPLC separation device, allowing for the separation of trace components identified by mass spectrometry. The samples obtained through separation undergo structural analysis using analytical instruments such as NMR, LC/MS, GC/MS, and MALDI-TOF/MS, ultimately leading to the synthesis of estimated compounds and the identification and structural determination of unknown substances. 【Features】 ■ Supports HPLC separation of optically active compounds using chiral columns ■ Capable of separating trace components identified by mass spectrometry ■ Ultimately combines separated samples with the synthesis of estimated compounds for the identification and structural determination of unknown substances *For more details, please refer to the related link page or feel free to contact us.

• others
• Other contract services

"Metal complexes" exhibit a wide variety of properties, such as catalysts and dye sensitizers, depending on the combination of ligands and metals. Our company conducts commissioned synthesis, including various ligand synthesis and complexation. Additionally, the synthesized metal complexes can be analyzed using techniques such as NMR, XRD, and ICP-OES. [Features] ■ We perform commissioned synthesis that includes various ligand synthesis and complexation. ■ The synthesized metal complexes can also be analyzed using techniques like NMR. ■ We have dark rooms and multiple glove boxes, allowing synthesis under various conditions. *For more details, please refer to the related links page or feel free to contact us.

• others
• Other contract services
• Other metal materials

Alkoxysilane compounds have been used as silane coupling agents for a long time and have recently gained attention as raw materials for unique mesoporous silica structures. Our company has a proven track record of synthesizing various alkoxysilane compounds, with supply capabilities of up to several hundred grams. Please feel free to contact us for inquiries or questions regarding product and technology information. 【Features】 ■ Long-standing use as silane coupling agents ■ Also gaining attention as raw materials for mesoporous silica ■ Proven track record in synthesizing various alkoxysilane compounds ■ Supply capabilities of up to several hundred grams *For more details, please refer to the related link page or feel free to contact us.

• others
• Other contract services

Our company is particularly focused on polymerization catalysts, and we have built a track record in synthesizing homogeneous transition metal catalysts starting from ligand synthesis. Based on our extensive knowledge and experience in organic synthesis, we can accommodate not only existing metal complexes but also newly designed metal complexes, as well as next-generation rare earth metal complexes and non-metallocene type transition metal catalysts. [Features] - Particularly focused on polymerization catalysts - Wide-ranging support based on extensive knowledge and experience in organic synthesis *For more details, please refer to the related links page or feel free to contact us.

• others
• Other contract services
• Other metal materials

In the Material Science Research Department Group 6, we synthesize products such as "-3-Hydroxybutanoic" and "-Pentanediol" using asymmetric reduction catalysts. In addition to the compounds listed below, we also offer custom synthesis using asymmetric reduction catalysts. For inquiries or questions regarding product and technology information, please feel free to contact us. 【Compounds】 ■ (R): -3-Hydroxybutanoic Acid Ethylester 98% ee ■ (R): -3-Hydroxybutanoic Acid Methylester 98% ee ■ (S): -3-Hydroxybutanoic Acid Ethylester 98% ee ■ (S): -3-Hydroxybutanoic Acid Methylester 98% ee ■ (2R, 4R): -Pentanediol 98% ee ■ (2S, 4S): -Pentanediol 98% ee *For more details, please refer to the related link page or feel free to contact us.

• others
• Other contract services

"Organic dyes" are attracting attention as highly efficient light absorbers and key materials for functionalization in the fields of electronic information and medical diagnostics. Our company has a proven track record in the synthesis of a wide variety of organic dyes, including Ru-based sensitizing dyes, phthalocyanine-based dyes, and squarilium-based dyes, utilizing the synthetic techniques we have developed over the years. For compounds with unknown synthetic routes, if you provide the structure, we can propose a synthetic route from our side. [Features] - Proven track record in the synthesis of a wide variety of organic dyes - For compounds with unknown synthetic routes, if you provide the structure, we can propose a synthetic route *For more details, please refer to the related link page or feel free to contact us.

• others
• Other contract services

Molecular imaging refers to a technique that non-invasively visualizes changes in molecular groups within living organisms (such as enzymes, genes, membrane proteins, etc.) and observes them dynamically and quantitatively. A representative method in this field is positron emission tomography (PET), which is well-known in current research. In recent years, technologies utilizing fluorescence and near-infrared light have also been applied in the fields of biochemistry and regenerative medicine. As it lies at the intersection of medicine, pharmacy, and engineering, this field is expected to see further development. Nard Institute will continue to support this area from the standpoint of organic compound development. [Theme] ■ VARGULA LUCIFERIN ■ Fluorescent labeling of organelles *For more details, please refer to the related links page or feel free to contact us.

• others
• Other contract services

Our company conducts the synthesis of various compounds, including fluorescent substances such as DOTA, TAMRA, Alexa, Biotin, and stable isotopes like deuterium, 13C, and 15N. We can introduce these compounds to your desired sites and also provide suggestions for compounds tailored to your intended applications. Based on our extensive synthesis experience, we support the labeling of a wide range of compounds, including general organic compounds, glycans, nucleic acids, and more. For inquiries or questions regarding product and technology information, please feel free to contact us. 【Features】 ■ Synthesis of compounds containing stable isotopes ■ Suggestions for compounds tailored to your intended applications ■ Support for the labeling of a wide range of compounds *For more details, please refer to the related link page or feel free to contact us.

• others
• Other contract services

Our company uses a method called the bottom-up approach for the synthesis of metal nanoparticles and the synthesis of composite materials that support metal nanoparticles on a carrier. Compared to the top-down approach, it is possible to achieve a narrower particle size distribution. We have a track record of various synthesis methods and a wide range of elements. Our materials are used in a variety of industries for applications such as conductive materials, magnetic materials, luminescent materials, DDS materials, cosmetic materials, battery materials, and catalyst materials. 【Features】 ■ It is possible to disperse in organic solvents by introducing organic substances onto the particle surface. ■ Compared to the top-down approach, it is possible to achieve a narrower particle size distribution. ■ We have a track record of various synthesis methods and a wide range of elements. ■ We actively try elements and synthesis methods that have not been implemented before. *For more details, please refer to the related link page or feel free to contact us.

• others
• Other metal materials

Our company offers contract synthesis services for inorganic materials, with a track record of over 500 custom syntheses. We can propose synthesis methods not only for those with established procedures but also for requests where only the compound structure is determined and the synthesis method is not. We utilize our in-house know-how and conduct literature research to suggest synthesis formulations. We possess various equipment related to inorganic synthesis and analysis of inorganic materials, allowing us to carry out everything from formulation proposals to analysis of the synthesized products. 【Synthesis Achievements (Excerpt)】 <Methods> ■ Solid-phase method, co-precipitation method, sol-gel method, hydrothermal synthesis method, solvothermal method, melt-quenching method, etc. <Materials> ■ Various solid materials for batteries (positive electrode active materials, negative electrode active materials, solid electrolytes, precious metal-supported catalysts), glass materials, MOF materials, metal nanoparticle materials, catalyst materials, etc. *For more details, please refer to the related link page or feel free to contact us.

• others
• Other contract services

At Nerd Research Institute, we utilize the fine chemical synthesis technologies accumulated so far to offer contract synthesis and research of dendrimer raw materials (building blocks). By employing various polymerization methods, we provide novel hyperbranched polymers. Additionally, upon request, we can assist in creating dendrimers with new functionalities by combining building blocks into the core. Our company synthesizes new dendrimer raw materials and dendrimers to meet your needs. 【Features】 ■ Synthesis of new dendrimer raw materials and dendrimers ■ Utilization of fine chemical synthesis technologies ■ Acceptance of contract synthesis and research for dendrimer raw materials ■ Also conducting contract synthesis of relatively easier-to-synthesize hyperbranched polymers than dendrimers ■ Providing novel hyperbranched polymers by employing various polymerization methods *For more details, please refer to the related links page or feel free to contact us.

• Other polymer materials
• others

Polymer materials are utilized in various industries, and a wide variety of polymer materials are sold by many manufacturers. Nard Laboratory's "Contract Synthesis Service" has a track record of delivering over 50 types of custom polymer compounds annually. Our company has numerous synthesis achievements not only in general radical polymerization but also in anionic polymerization, cationic polymerization, and step-growth polymerization, with a significant number of successful syntheses of both random polymers and block polymers. [Features] - Implementation from investigation of synthesis methods - Ability to synthesize various types of resins by using different polymerization methods - Control of molecular weight and molecular weight distribution is possible by using living polymerization techniques - Capable of conducting not only polymerization but also modification reactions *For more details, please refer to the related link page or feel free to contact us.

• Other polymer materials
• others

We would like to introduce our synthesis technology for "metabolites and degradation products." In the fields of pharmaceuticals and pesticides, we carry out the synthesis of standard samples of metabolites, impurities, and degradation products necessary for overseas registration and other requirements. Additionally, in the case of compounds with unknown structures, we utilize analytical instruments such as LC-MS and NMR to perform structure analysis, determination, synthesis, analysis, and reporting. 【Features】 ■ Synthesis of standard samples of metabolites, impurities, and degradation products ■ Utilization of analytical instruments such as LC-MS and NMR for compounds with unknown structures ■ Execution of structure analysis, determination, synthesis, analysis, and reporting *For more details, please refer to the related link page or feel free to contact us.

• others

We synthesize nucleosides modified at the base or sugar parts using our accumulated organic synthesis technology, and deliver them as amides that can be immediately utilized in automated oligonucleotide synthesis devices. Additionally, we also support the phosphorylation of modified nucleosides and provide high-purity triphosphates, diphosphates, and monophosphates using advanced purification techniques. [Achievements] ■ Synthesis of non-natural nucleoside amides ■ Scale-up production of non-natural nucleoside amides ■ Synthesis of non-natural nucleotides *For more details, please refer to the related links page or feel free to contact us.

• others

Lipids include simple lipids such as acylglycerols and complex lipids such as phospholipids and glycolipids, and they are known to have various functions as important substances that constitute living organisms. On the other hand, in the field of drug delivery systems (DDS), lipid compounds are utilized with liposomes as transport carriers. Our company leverages synthetic and purification technologies to synthesize lipid compounds necessary for research and development of lipid molecules such as acylglycerols, phospholipids, and glycolipids, and provides the required samples. Furthermore, we also accommodate custom synthesis according to requests, including various fluorescent labeling, stable isotope labeling such as 2H and 13C, and PEG modification. 【Features】 ■ Synthesis of lipid compounds necessary for research and development, providing the required samples ■ Custom synthesis according to requests, including stable isotope labeling and PEG modification *For more details, please refer to the related link page or feel free to contact us.

• others

We custom synthesize peptides necessary for the development process. By providing the required samples, we contribute to the efficiency and speed of research and development. We synthesize various fluorescently labeled compounds, including stable isotopes such as D, 13C, and 15N, and propose the sites of isotope incorporation and synthesis pathways. Additionally, we provide small quantities of samples containing peptides derived from basic frameworks in multiple specimens. You can rely on us for everything from the design of the synthesis method to delivery. 【Features】 ■ Custom sample synthesis for research ■ Fluorescent and stable isotope labeling ■ Small quantity, multiple specimen synthesis ■ Research support - FTE contracts ■ Sample synthesis and purification using high-purity equipment *For more details, please refer to the related link page or feel free to contact us.

• others

Our company conducts the synthesis of glycan and glycan derivatives at various scales, from a few milligrams for research purposes to process development aimed at future commercialization. We can accommodate not only linear glycans but also the construction of complex branched glycans. We have a proven track record in the synthesis of glycan derivatives, regardless of whether they are natural or non-natural. Additionally, we support life science research through the modification of N-linked and O-linked glycans, as well as custom synthesis of glycoproteins. 【Features】 ■ Synthesis of glycans and glycan derivatives at various scales ■ Capability to construct complex branched glycans ■ Proven track record in the synthesis of glycan derivatives, both natural and non-natural ■ Support for life science research *For more details, please refer to the related link page or feel free to contact us.

• others

Our company has both batch and flow-type photoreaction devices, allowing us to carry out reactions using the most suitable methods. In the past, we have developed flow-type photoreactions for the synthesis of phenazines, achieving shorter reaction times and improved yields compared to batch methods. Based on these results, we propose improvements for effective synthesis by selecting appropriate techniques tailored to the characteristics of photoreactions. 【Features】 ■ Equipped with both batch and flow-type photoreaction devices ■ Capable of conducting reactions using suitable methods ■ Reduction in reaction time and improvement in yield compared to batch methods ■ Selection of appropriate techniques based on the characteristics of photoreactions ■ Proposals for improvements towards effective synthesis *For more details, please refer to the related links page or feel free to contact us.

• Other inspection equipment and devices
• Testing Equipment and Devices
• others

Microwaves are a type of electromagnetic wave, and when microwaves are irradiated, they are absorbed by a substance depending on its dielectric properties, causing the substance itself to heat up. This phenomenon is utilized as a new heat source for organic synthesis reactions. Due to the wide variety of applicable reactions, our company conducts various reactions using microwave synthesis equipment. **Effects of Microwaves** - Reduction of reaction time, suppression of side reactions, and improvement of yields are possible. - Since it acts directly on the substance, it allows for solvent-free reactions, uniform heating in solid-phase reactions, and promotes reactions. - The ability to conduct reactions at temperatures higher than the boiling point leads to effects such as improved solubility. - Microwave-specific effects such as positional selectivity, stereoselectivity, and high crystallization. *For more details, please refer to the related link page or feel free to contact us.*

• Other contract services

In recent years, we support continuous process development using microreactors and multi-stage continuous stirred-tank reactors (multi-stage CSTR) in the increasingly recognized field of flow synthesis. We can accommodate flash chemistry, avoidance of ultra-low temperature reactions, high-temperature reactions, high-pressure reactions, heterogeneous reactions, gas-liquid, solid-liquid, and gas-solid-liquid reactions, demonstrating effectiveness in precise reaction control, utilization of unstable intermediates, improved safety, and one-pot synthesis. Additionally, we can handle the difficult management of slurries and continuous crystallization in continuous processes. 【Features】 ■ Capable of accommodating flash chemistry (ultra-fast reactions), avoidance of ultra-low temperature reactions, high-temperature reactions, high-pressure reactions, heterogeneous reactions, gas-liquid, solid-liquid, and gas-solid-liquid reactions ■ Effective in precise reaction control, utilization of unstable intermediates, and improved safety ■ Able to handle the difficult management of slurries and continuous crystallization in continuous processes *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• Mixer/agitator

Our company has established a quality assurance system based on the international standard ISO 9001 for quality management systems. We also accommodate the production of small quantities and small lots of products. Additionally, we provide support for scaling up chemical manufacturing, offering comprehensive consulting services from process development to production management. 【Features】 ■ A quality assurance system based on the international standard ISO 9001 ■ Capable of producing small quantities and small lots ■ Support for scaling up chemical manufacturing ■ Comprehensive consulting services provided *For more details, please refer to the related link page or feel free to contact us.

• Other contract services
• ISO-related consultant

Our company provides "Process Research, Scale-Up Synthesis, and Manufacturing Services." In "Improvement of Synthesis and Manufacturing Routes," we conduct various studies aimed at improving the yield of existing routes, reducing costs, and enhancing productivity, and we propose improved routes based on medicinal chemistry routes. In "Scale-Up," we carry out syntheses on a scale of hundreds of grams to several kilograms based on laboratory synthesis results. We also develop manufacturing formulations for factory scale production based on laboratory synthesis achievements. 【Service Contents】 ■ Improvement of Synthesis and Manufacturing Routes ■ Scale-Up ■ Impurity Investigation ■ Process Development Support *For more details, please refer to the related link page or feel free to contact us.

• Other contract services

With the advancement of medicine and the aging population, there is a growing demand for improved health and quality of life, which is creating new needs for pharmaceutical development. Drugs that show effects in extremely small amounts can also pose a high risk of health hazards in the development and manufacturing processes. Our company has been operating containment facilities since April 2016 with the aim of safely and securely handling these substances. Leveraging our long-standing expertise in organic synthesis and this facility, we provide safe and secure contract synthesis and purification services for highly pharmacologically active compounds, contributing to the acceleration of development in this field. 【Facility Overview】 ■ Manufacturing Room: 17m² (2 Hazard Rooms) and DG Room / Pass Box ■ Containment Equipment: Hazard Room / Safety Cabinet / Draft Chamber ■ Static Pressure Management: -15Pa to -30Pa ■ Manufacturing Environment / External Environment: Class 100,000 HEPA performance / HEPA exhaust *For more details, please refer to the related link page or feel free to contact us.

• Other contract services