[End] Innovation Forum 2023 "Simplification of pDNA|mRNA Manufacturing Process by Sartorius"

New standards for integrity testing machines that comply with the latest data integrity and QRM.

The Zaltcheck series is the most widely used in the pharmaceutical industry and has gained the trust of many users as a proven integrity testing device. The Zaltcheck 5 Plus is the latest model in the series, released in 2019. With new technology, we have further enhanced usability, compliance with the latest regulations, and error detection capabilities. It sets a new standard for integrity testing devices that meets the needs of customers seeking higher levels of testing. 【Main Features of the Product】 ■ Specifications that exceed QRM legal requirements - Automatic detection of test setting errors and abnormal test conditions ■ Highest level of data integrity - Customized Linux OS - Data encryption and dual data backup ■ Intuitive and excellent operability - Large touchscreen with a clear viewing angle and intuitive user interface - First in the series to support Japanese display ■ Achievement of Health, Safety, and Environment (HSE) - Explosion-proof specifications (ATEX IECEx & FM certified) that allow safe testing of alcohol-wetted filters *For more details, please contact us or download the PDF materials.

• others

Bioreactor system for cell line development and process optimization.

The Ambr1515 Generation 2 is a high-throughput "automated micro-scale bioreactor system" that reproduces the performance of laboratory-scale bioreactors. The system consists of single-use vessels, an automated workstation, and enhanced convenience software. It is designed to be installed in a standard biosafety cabinet for aseptic operations, allowing for parallel monitoring and control of 24 or 48 micro-bioreactor cultures. As the manufacturing processes for biopharmaceuticals become more complex and the density of cultures increases, scientists around the world are facing an unprecedented challenge in developing "clone, medium, and process" that meet new demands. The Ambr15 Generation 2 system enhances equipment performance that influences the success of cultures, improves flexibility, and incorporates new features that reflect user feedback. It helps address the aforementioned challenges and supports the acceleration of research by scientists.

• others

Introducing options and accessories that can be added to the Ambr 15 Generation 2.

You can find the following information in this catalog: ▪ System specifications ▪ Compatible at-line analyzers ▪ Expandable options ▪ Accessories ▪ Ambr 15 microbioreactor (culture vessel) ▪ Plates and chips

• Other physicochemical equipment
• others

Single-use culture equipment that meets the requirements of the microbial culture process.

【Advantages】 ▪ Specifications designed to accommodate all microbial culture processes ▪ Production of plasmid DNA ▪ Microbial culture bags that have undergone qualification for GMP manufacturing ▪ Improved productivity and user-friendly ▪ Refined process control proven in cell culture

• others

Rapid at-line analysis chromatography solution

【Features】 ▪ High-speed, high-resolution HPLC analysis for pDNA processes ▪ Acceleration of PD and stabilization of manufacturing and quality through at-line monitoring ▪ Ability to obtain a lot of important information in a short time, with low effort and low cost ▪ Unique monolithic column for CIMac pDNA analysis ▪ User guide, dedicated validated methods, SOPs, and standard materials included

• others

Fully automated tangential flow filtration system using a closed-loop single-use system suitable for process development to pilot-scale manufacturing.

**Features** - Single-use TFF specifically designed for 1 to 20L scale, providing cost-effective solutions from process development to pilot. - Ready-to-use and closed system, resulting in low bio-burden risk. **Characteristics in ADC Manufacturing** - Automation of three processes: ADC synthesis, precipitate removal, and TFF within a single system. - Reduction of funding, labor, installation space, and process risks, enabling a seamless transition from process development to small-scale commercial ADC manufacturing. - Flexible process sequence control allows for compatibility with various ADC manufacturing protocols. - Stirring optimized for minimal capacity with temperature control.

• others

Technology for clarification of cell cultures and removal of impurities: Sartoclear Depth Filter

The Zaltclear Depth Filter product family is a cellulose-based filter that contains diatomaceous earth. It is used in the biotechnology and pharmaceutical industries, where high solid removal capabilities are required to meet strict standards. In a dual-layer (DL) format, it can filter cell culture media with a cell density of less than 15×10⁶/mL from the process development stage to the commercial production stage.

• others

Please check the Japanese version catalog for a significant increase in operability and stirring power!

A high-speed, flexible, and intelligent single-use mixer that accommodates all stirring processes in cGMP-compliant bioprocessing. In mixing processes within the bioprocess environment, quality and efficiency are critically important, and the choice of mixing equipment has a dramatic impact on both. A high-speed, flexible single-use mixer enhances manufacturers' competitiveness and improves productivity.

• others

A robust, complete, and scalable solution for frozen storage and frozen transportation.

Based on over 15 years of experience in the design of single-use freezing and thawing solutions, we have established Celsius pre-design solutions (PDS) for all processes requiring frozen storage and frozen transport, at both lab scale and manufacturing scale. Celsius PDS separates the downstream process and is equipped with the necessary functions for the safe transport of active pharmaceutical ingredients to pharmaceutical manufacturing facilities.

• others

Smart condition setting, a genuine end-to-end integrated freeze-thaw system.

A robust, complete, and scalable solution for frozen storage and frozen transport. Sartorius offers lab-scale Celsius solutions for smarter and earlier process decisions in the management of frozen active pharmaceutical ingredients. The Celsius Lab-scale Platform enables the characterization of freezing and thawing within single-use bags of 30 mL to 100 mL, featuring complete scalability up to the commercial-scale Celsius Platform (CFT, FFT, and FFTP).

• Other physicochemical equipment
• others

Freeze-thaw solutions for seamless scalability to commercial production.

Sartorius, with over 15 years of experience in the design of freeze-thaw solutions, offers lab-scale and manufacturing-scale solutions for all steps of processes requiring frozen storage and frozen transport. This enables biopharmaceutical manufacturers to effectively decouple downstream processes and safely transport active pharmaceutical ingredients to drug manufacturing facilities. The Celsius Platform, equipped with options for blast freezers, horizontal freezers, and vertical plate freezers, provides an end-to-end integrated approach that enables monitoring and control to broadly ensure product quality and integrity.

• Other physicochemical equipment
• others

Nitto Kohki will hold the "2025 Attack Fair in Meiko" for two days from July 23 (Wednesday) to July 24 (Thursday), 2025, at the "Kowa Seminar Plaza 2F Training Room NO.12 (inside Kowa Sports Land)." The Attack Fair is an exhibition where you can actually "see, touch, and operate" Nitto Kohki's products. Additionally, there will be wonderful souvenirs for attendees and many fun activities planned. We look forward to welcoming everyone!

The "Building Maintenance Human Fair & Clean EXPO 2025," which will be held from November 19 (Wednesday) to 21 (Friday), 2025, is an annual exhibition specializing in the building maintenance field, organized by the National Building Maintenance Association and the Japan Management Association. The field reporting app "Smart Attack" is celebrating its 15th anniversary this year since its release. It has a proven track record of being used by many customers as an efficiency tool for various building maintenance tasks such as cleaning, security, and facility management! At our exhibition booth, we will present a demonstration and the latest information about the completely renewed new app "Smart Attack V3." ★★★ Points ★★★ Fully renewed version: New app "Smart Attack V3" The fully renewed version of the new app "Smart Attack" is here! You can see the latest version "Smart Attack V3," which has improved processing speed and a completely revamped design, in a demonstration. All of us at the company look forward to your visit.

Naviace Co., Ltd. will be exhibiting at the "39th Hokkaido Technology and Business Exchange Meeting" business expo held in Sapporo, Hokkaido (https://www.business-expo.jp/). Under the theme "Change Challenges into Strengths with Carbon Neutrality!!", we will showcase our environmentally friendly cardboard pallet, "Navi Pallet". <Product Features> - Lightweight and high load capacity to improve work efficiency - 100% recyclable and ideal for one-way operations - No heat treatment required, making it suitable for export - High design flexibility for adaptable solutions - Contributes to addressing the logistics 2024 problem and reducing CO₂ emissions The Navi Pallet not only supports the transition from manual loading and unloading to palletization but also contributes to achieving carbon neutrality. We will also display actual Navi Pallets that have been implemented at the venue. Please come and experience the "strength" and "lightness" for yourself. Exhibition Area: Sapporo Chamber of Commerce and Industry Manufacturing Corner

Techne Measurement Co., Ltd. will be exhibiting at the 66th Battery Discussion Conference, which will be held at Wink Aichi from November 18 (Tuesday) to November 20 (Thursday), 2025. This time, we will showcase dew point meters and low dew point calibrators for the battery industry. Please be sure to visit the Techne Measurement booth.

As global inter-company competition intensifies, there is a growing demand for the investigation and analysis of foreign patents. However, due to language barriers and the vast amount of patent information available, it is challenging to search for only relevant technologies, necessitating advanced research skills to conduct efficient investigations. In response, we would like to introduce our patent research support service "PatentSQUARE," which allows you to learn the basics to advanced applications of foreign patent investigations, along with useful features and the latest functionalities. ≪Part One: Recommended for Those Who Are Starting Foreign Patent Investigations≫ - Unique input methods for specific conditions when searching foreign literature - How to conduct investigations with an awareness of patent families - Equipped with an English company name dictionary to support the resolution of discrepancies in notation during analysis ≪Part Two: Recommended for Those Who Want to Analyze Foreign Patents or Conduct Research in New Areas and Competitors≫ - Convenient ways to utilize AI searches to overcome the question of where to start - Practical methods for creating a parent set, analyzing it, and utilizing the information afterward - What can be done "because" of the IP BI dashboard If you want to improve the efficiency of foreign patent investigations or easily conduct analyses of domestic and foreign patents, please feel free to join us. *You can participate in only the themes you prefer.