July 4th Process Modeling and Simulation Seminar "From Continuous Production Process of Solid Dosage Forms to Oral Absorption" *The day before the Interfaces event

Visualize the manufacturing process for pharmaceuticals and food! For improving quality and reviewing production costs in active ingredient manufacturing and formulation processes. *Demo tests are currently being conducted.

This is a modeling tool developed in collaboration with a U.S. mega-pharma company. Recently, the pharmaceutical industry has been transitioning from batch to continuous production, and it is being used for process design and control system considerations. It is a model library of gPROMS FormulatedProducts. In continuous production processes, advanced quality management (PAT, QbD, RTRT) and the ability to accommodate small-batch, diverse production become possible, but at the same time, high-precision process modeling technology becomes essential. If you want to "reduce plant construction costs," "increase production volume at existing plants," or "improve product quality (particle size distribution)," please feel free to contact us! You can watch the video on YouTube: https://youtu.be/AJZcgI-r2Ik

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Pre-testing in simulations allows for risk avoidance in scaling up. We offer consulting services. Monthly contracts available.

The spray dryer allows for the consideration of product quality variation control and equipment scale-up (enlargement) by simulating factors that influence particle size control, moisture content control, and particle shape during the manufacturing process. In modeling, the particle size distribution is calculated based on the Population Balance equation, and the drying process of the particles is also taken into account. Additionally, representing adhesion to the walls is an important requirement in the simulation. With the integration of Siemens' STAR-CCM+, it is possible to analyze the actual gas flow in detail, which can be used for considerations of scale-up and operational improvements. This is an optional feature of gPROMS FormulatedProducts. *For more details, please download the catalog or contact us.

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For increasing production volume, optimizing operations, scale-up design, cost reduction, energy saving, etc.!

<gPROMS FormulatedProducts Crystallization Process Library> It can be used for various considerations and decision-making in production volume enhancement, operational improvement, and process optimization. To build efficient procedures (recipes) in the crystallization process, we will efficiently carry out operations in the following flow and achieve these within a short period (approximately 1 to 2 months). Modeling → Experiment → Model Verification (Parameter Estimation, Validation) → Process Optimization Consideration → Scale-Up Consideration The ability to automatically perform parameter estimation with the tool is a significant factor in reducing the consideration period. Additionally, since it is a kinetic model (expressing mechanisms in mathematical formulas), the number of parameters is kept to a necessary minimum. Furthermore, tools that automatically optimize cooling temperature reduction methods and patterns, the amount and timing of seed crystals, evaporation rates, and heating patterns are powerful, and scale-up may be conducted in conjunction with CFD (Computational Fluid Dynamics) simulations when necessary.

• Contract Analysis

For the pharmaceutical industry and university pharmacy departments: Materials are currently being provided for the simulation of "continuous production" and the optimization of new drug development.

gPROMS Formulated Products is a modeling tool for solid and powder processes. In cases applied to pharmaceutical processes, it enables consistent performance analysis of the entire system, from active pharmaceutical ingredient (API) manufacturing through formulation processes to risk analysis of oral absorption. Our software has already been implemented by major pharmaceutical companies in Europe, the United States, and Japan. We will send you three simulation materials related to API manufacturing, crystallization, formulation, and oral absorption (Technical Information Association, separate print) by mail (free of charge). 1. Optimal design of API manufacturing and formulation processes using modeling tools 2. Optimization of crystallization processes using simulation and modeling tools 3. Correlation between process parameters and quality characteristics using AI We hope this will be useful as part of further efficiency improvements in "continuous production" and new drug development. If you are interested, please contact us by writing "Request for Process Modeling Materials" in the "Inquiry" section.

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• Analysis Services

Visualize continuous processes! For improving quality and reviewing production costs in active pharmaceutical ingredient manufacturing and formulation processes. *We provide support from demo tests to utilization follow-up.

This is a modeling tool developed in collaboration with a U.S. mega-pharma company. Recently, the pharmaceutical industry has been transitioning from batch production to continuous production, and it is being used for process design and control system considerations. It is a model library of gPROMS FormulatedProducts. In continuous production processes, advanced quality management (PAT, QbD, RTRT) becomes possible, as well as the ability to handle small-batch, multi-product production, but at the same time, high-precision process modeling technology becomes essential. If you have any inquiries such as "I want to reduce plant construction costs," "I want to increase production volume at existing plants," or "I want to improve product quality (particle size distribution)," please feel free to contact us! 【Features】 ■ Capable of steady-state and dynamic (dynamic) simulation ■ Easily handles multiple recycle streams ■ Allows for optimization considerations of plant design and operation methods ■ Can identify and estimate process equipment performance from test data ■ Provides graphical representation of batch plant operating procedures ■ Can be linked with crystallization process analysis libraries ■ Can be linked with oral absorption analysis libraries *For more details about the product, please download the PDF from the link below.

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• Other analyses
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We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely invite you to visit us during this busy time. 【 Exhibition Name 】 Automotive Technology Exhibition 2025 YOKOHAMA https://aee.expo-info.jsae.or.jp/ja/yokohama/ (An "online exhibition" will also be held during and around the event period) 【 Dates 】 May 21 (Wednesday) - 23 (Friday), 2024 10:00 AM - 6:00 PM *On the final day, 9:00 AM - 4:00 PM (Online exhibition: May 14 (Wednesday) - June 4 (Wednesday)) 【 Venue 】 Pacifico Yokohama (1-1-1 Minatomirai, Nishi-ku, Yokohama, Kanagawa Prefecture) Our booth number: "Concourse 505"

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to attend this event. 【 Exhibition Name 】 27th INTERPHEX Week Tokyo https://www.interphex.jp/tokyo/ja-jp.html 【 Dates 】 July 9 (Wednesday) - 11 (Friday), 2025 10:00 AM - 5:00 PM 【 Venue 】 Tokyo Big Sight (3-11-1 Ariake, Koto-ku, Tokyo 135-0063)

We are pleased to announce the upcoming webinar "Analytical Instruments Course - Basic Edition." This course is designed for anyone who will be involved in analytical work starting this spring, as well as those who wish to revisit the principles of analytical methods. This time, we will explain sulfur, nitrogen, and chlorine analysis instruments, as well as total organic carbon analysis instruments. If you are interested, please register for participation through the details and registration button. Start times: 14:00 - Nitrogen, Sulfur, and Chlorine Analysis Instruments 15:00 - Total Organic Carbon Analysis Instruments

We are pleased to announce the upcoming webinar "Analytical Instrument Course - Basics Edition." This course is designed for anyone who will be involved in analytical work starting this spring, as well as those who wish to revisit the principles of analytical methods. We believe that everyone will find the content satisfying. If you are interested, please register for participation using the application button. This time, the program will be held as follows: 1:00 PM - Microwave Sample Digestion System 2:00 PM - Atomic Absorption Spectrophotometer 3:00 PM - ICP Emission Spectrometer

The next official Yocto Project practical course (LFD461-JP) is scheduled to be held over three days from June 9 (Tuesday) to June 11 (Thursday), 2026. This practical course integrates the knowledge and know-how gained from Yocto-related development, support, and seminars conducted by Lino. We encourage companies that want to learn Yocto or utilize it more effectively to consider participating.