July 4th Process Modeling and Simulation Seminar "From Continuous Production Process of Solid Dosage Forms to Oral Absorption" *The day before the Interfaces event

Visualize the manufacturing process for pharmaceuticals and food! For improving quality and reviewing production costs in active ingredient manufacturing and formulation processes. *Demo tests are currently being conducted.

This is a modeling tool developed in collaboration with a U.S. mega-pharma company. Recently, the pharmaceutical industry has been transitioning from batch to continuous production, and it is being used for process design and control system considerations. It is a model library of gPROMS FormulatedProducts. In continuous production processes, advanced quality management (PAT, QbD, RTRT) and the ability to accommodate small-batch, diverse production become possible, but at the same time, high-precision process modeling technology becomes essential. If you want to "reduce plant construction costs," "increase production volume at existing plants," or "improve product quality (particle size distribution)," please feel free to contact us! You can watch the video on YouTube: https://youtu.be/AJZcgI-r2Ik

• simulator
• Analysis Services

Pre-testing in simulations allows for risk avoidance in scaling up. We offer consulting services. Monthly contracts available.

The spray dryer allows for the consideration of product quality variation control and equipment scale-up (enlargement) by simulating factors that influence particle size control, moisture content control, and particle shape during the manufacturing process. In modeling, the particle size distribution is calculated based on the Population Balance equation, and the drying process of the particles is also taken into account. Additionally, representing adhesion to the walls is an important requirement in the simulation. With the integration of Siemens' STAR-CCM+, it is possible to analyze the actual gas flow in detail, which can be used for considerations of scale-up and operational improvements. This is an optional feature of gPROMS FormulatedProducts. *For more details, please download the catalog or contact us.

• simulator
• Contract Analysis
• Analysis Services

For increasing production volume, optimizing operations, scale-up design, cost reduction, energy saving, etc.!

<gPROMS FormulatedProducts Crystallization Process Library> It can be used for various considerations and decision-making in production volume enhancement, operational improvement, and process optimization. To build efficient procedures (recipes) in the crystallization process, we will efficiently carry out operations in the following flow and achieve these within a short period (approximately 1 to 2 months). Modeling → Experiment → Model Verification (Parameter Estimation, Validation) → Process Optimization Consideration → Scale-Up Consideration The ability to automatically perform parameter estimation with the tool is a significant factor in reducing the consideration period. Additionally, since it is a kinetic model (expressing mechanisms in mathematical formulas), the number of parameters is kept to a necessary minimum. Furthermore, tools that automatically optimize cooling temperature reduction methods and patterns, the amount and timing of seed crystals, evaporation rates, and heating patterns are powerful, and scale-up may be conducted in conjunction with CFD (Computational Fluid Dynamics) simulations when necessary.

• Contract Analysis

For the pharmaceutical industry and university pharmacy departments: Materials are currently being provided for the simulation of "continuous production" and the optimization of new drug development.

gPROMS Formulated Products is a modeling tool for solid and powder processes. In cases applied to pharmaceutical processes, it enables consistent performance analysis of the entire system, from active pharmaceutical ingredient (API) manufacturing through formulation processes to risk analysis of oral absorption. Our software has already been implemented by major pharmaceutical companies in Europe, the United States, and Japan. We will send you three simulation materials related to API manufacturing, crystallization, formulation, and oral absorption (Technical Information Association, separate print) by mail (free of charge). 1. Optimal design of API manufacturing and formulation processes using modeling tools 2. Optimization of crystallization processes using simulation and modeling tools 3. Correlation between process parameters and quality characteristics using AI We hope this will be useful as part of further efficiency improvements in "continuous production" and new drug development. If you are interested, please contact us by writing "Request for Process Modeling Materials" in the "Inquiry" section.

• simulator
• Analysis Services

Visualize continuous processes! For improving quality and reviewing production costs in active pharmaceutical ingredient manufacturing and formulation processes. *We provide support from demo tests to utilization follow-up.

This is a modeling tool developed in collaboration with a U.S. mega-pharma company. Recently, the pharmaceutical industry has been transitioning from batch production to continuous production, and it is being used for process design and control system considerations. It is a model library of gPROMS FormulatedProducts. In continuous production processes, advanced quality management (PAT, QbD, RTRT) becomes possible, as well as the ability to handle small-batch, multi-product production, but at the same time, high-precision process modeling technology becomes essential. If you have any inquiries such as "I want to reduce plant construction costs," "I want to increase production volume at existing plants," or "I want to improve product quality (particle size distribution)," please feel free to contact us! 【Features】 ■ Capable of steady-state and dynamic (dynamic) simulation ■ Easily handles multiple recycle streams ■ Allows for optimization considerations of plant design and operation methods ■ Can identify and estimate process equipment performance from test data ■ Provides graphical representation of batch plant operating procedures ■ Can be linked with crystallization process analysis libraries ■ Can be linked with oral absorption analysis libraries *For more details about the product, please download the PDF from the link below.

• simulator
• Other analyses
• Analysis Services

We will hold an online seminar as follows. The corporate perspective on the introduction of monitoring systems is changing year by year. We will explain the monitoring systems for machine tools that are currently needed, using various case studies to discuss the changes in the industry environment, what challenges customers perceive, their expectations for monitoring systems, and the effects of their implementation. This seminar will provide insights into specific approaches for your company's introduction of monitoring systems. Date and Time: February 12, 2025 (Thursday) 14:00 - 15:00 Instructor: Monitoring System Representative, ARTIS (MARPOSS Corporation Sales Development Department) Target Audience: - Customers considering the introduction of monitoring systems who want to know the specific process leading to implementation. - Customers interested in what challenges other companies have identified that led to the introduction of monitoring systems. - Customers researching the latest trends in monitoring systems for machine tools. We sincerely look forward to your participation.

We will be exhibiting at Robot Technology Japan from June 11 (Thursday) to June 13 (Saturday), 2026. Exhibits: Various hex wrenches from BONDHUS, tooling wagon from Huot, drill-specific cabinet, and webbing. If you visit Robot Technology Japan, please be sure to stop by our booth (booth number E94).

[Speaker] Kato Shun, Senior Consultant, Global Manufacturing Consulting Department, Consulting Division, Nomura Research Institute, Ltd. [Key Lecture Content] In recent years, the vibrant atmosphere at international technology exhibitions is one example of the growing expectations for the practical application of Physical AI and humanoids in the manufacturing industry. The utilization of AI technology is rapidly expanding into product development, design processes, and manufacturing sites. IT and capital investments in manufacturing are currently at a critical turning point, shifting from traditional digital transformation (DX) to the next phase based on AI and robotics. Furthermore, these environmental changes present a favorable opportunity for Japan's manufacturing sector to create new value and realize business opportunities. This lecture will present the direction of activities that Japan's manufacturing industry should undertake based on trends among advanced players in Europe and the United States.

[Speaker] Koichiro Danno, Head of the Social and Policy Design Unit, Research and Consulting Division, Japan Research Institute, Inc. [Lecture Items] May 7 (Thursday) <Session 1> Knowledge and Practices to be Aware of in Renewable Energy Power and Environmental Value Transactions 1. The Mechanism of Environmental Value Transactions in Our Country 2. International Trends in Environmental Value and Renewable Energy Transactions 3. The Mechanism of Renewable Energy Power Transactions in Our Country 4. Overview of Renewable Energy Power and Environmental Value Transaction Schemes 5. Points to Note and Business Opportunities in Each Scheme 6. Summary 7. Q&A May 13 (Wednesday) <Session 2> Knowledge and Practices to be Aware of Based on the Implementation of FIP, Corporate PPA, etc. in April 1. Overview of the FIP System 2. Business Opportunities Associated with the Transition to FIP in Other Countries 3. Corporate PPA Schemes Utilizing the FIP System 4. Self-Delivery Type Off-Site PPA 5. Requirements for Future Renewable Energy Operators 6. FIP Premium Estimation Process 7. Drastic Changes in the New Rules for FY2026 8. Summary 9. Q&A

This seminar will systematically explain the increasing importance of data integrity (DI) and CSV compliance in the field of pesticide GLP. ▶ Why is DI compliance required now? ▶ Proper data management based on the ALCOA+ principles ▶ Efficient DI measures through risk assessment ▶ DI compliance solutions and the latest analytical technologies from Agilent As a special lecturer, Dr. Kazuhiko Motoba, Executive Officer and Head of the Research Division at Japan Pesticide Co., Ltd., will be speaking. 【Event Overview】 Date: Tuesday, April 21, 2026 Time: 13:00–16:30 (Registration starts at 12:30) Venue: Bellesalle Yaesu Participation Fee: Free (Capacity: 50 people / In-person attendance only) Gain practical insights directly related to your work at the venue.