Notice of Participation in the "Japan Biomaterials Society" Exhibition from November 6 (Monday) to November 7 (Tuesday), 2023.

There are numerous research examples, including skin models and models of various organs (heart, liver, kidneys, etc.)!

We would like to introduce our bio 3D printer, the "BIO X Series." We offer the "BIO X" and "BIO X6," which allow for flexible use according to research purposes. As an application example, in "cell and molecule encapsulation," cells, drugs, proteins, spheroids, and more can be embedded within hydrogel beads. Additionally, it is possible to print multiple cells and materials using up to six print heads. 【Flexible Use According to Research Purposes】 ■ Utilize multiple print heads ■ Continuously print models ■ Create flexible 3D models ■ Dispense materials like Matrigel *For more details, please refer to the PDF document or feel free to contact us.

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Compatible with a wide range of materials. Ensures high cleanliness with UV-C lamps and HEPA filters. Also focuses on ease of use.

The "BIO X" is a desktop bio 3D printer equipped with an intelligent print head (iPH) that can accommodate a wide range of materials. It features two high-output fans at the top of the device, which pressurize the cavity with clean air filtered through HEPA filters and other means. Additionally, it is equipped with UV-C lamps that maintain a clean printing environment through an automatic cycle. 【Features】 ■ Compatible with temperature-sensitive materials such as collagen and gelatin ■ A wide lineup of high-performance print heads ■ Easy replacement of print heads ■ Suitable for a wide range of applications *For more details, please refer to the materials. Feel free to contact us with any inquiries.

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Highly flexible 3D bioprinting! Featuring a bio 3D printer with cell ink.

Cell culture, which is essential in fields such as regenerative medicine, oncology using stem cells, drug discovery, and toxicity evaluation, is still predominantly conducted in two-dimensional cultures. However, some may wonder if conducting experiments in three dimensions, similar to the cells themselves and the surrounding environment in vivo, would allow for a more faithful study of cell behavior. In this document, we introduce the importance of three-dimensional culture and our company's 3D bioprinting technology, as discussed with our application specialists. We encourage you to read it. [Contents (partial)] - Highly flexible 3D bioprinting - Usable even by beginners, allowing for plenty of trial and error - Extrusion printer BIO X - Light-curing bioprinting LUMEN X+ *For more details, please refer to the PDF document or feel free to contact us.

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Cells are suspended in a gelatin-based biomaterial and shaped using a bioprinter. Subsequently, bone formation differentiation is induced and evaluated during culture.

We are introducing application examples utilizing the BIO X series 3D bioprinter. This product allows for flexible use tailored to research purposes across a variety of applications. There are numerous research cases, including skin models, various organ models (such as heart, liver, kidney, etc.), and cancer disease models. [Contents] - Bioprinting of primary human mesenchymal stem cells and vascular endothelial cells - Multilayer tissue models using multiple cells and materials - Encapsulation of cells and molecules - High-precision automatic dispensing of Matrigel *For more details, please refer to the PDF materials or feel free to contact us.

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Developed a bio-ink composed of human endothelial cells, human pericytes, and animal collagen, and printed the structure.

Current artificial skin graft products promote wound healing, but they ultimately detach because they do not integrate with the patient's skin tissue. The lack of a functional vascular system in artificial grafts poses a significant barrier. We have developed a bioink composed of human endothelial cells, human pericytes, and animal collagen, allowing us to print these structures using the "CELLINK BIO X" and a temperature-controlled print head. This combination of critical elements enables cells to initiate communication and begin forming vascular structures with characteristics similar to biological blood vessels within weeks. Once the vessels are formed, they can exchange nutrients and waste, sustaining the survival of the graft. [Overview] ■ Institution: Rensselaer Polytechnic Institute ■ Challenge: The lack of a functional vascular system in artificial grafts is a significant barrier ■ Solution: Using CELLINK BIO X and a temperature-controlled print head ■ Results - Begin forming vascular structures with characteristics similar to biological blood vessels within weeks - Once vessels are formed, they can exchange nutrients and waste, maintaining the survival of the graft *For more details, please refer to the related links or feel free to contact us.

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Introducing bio-printing technology for 3D heart models designed for personalized medicine and transplantation.

In Dr. Carmine Gentile's laboratory in Sydney, research is being conducted to develop bio-printed heart tissue using patient-specific cells to minimize the risk of transplant rejection. In a 2020 study, mouse cells were bio-printed using alginate-gelatin hydrogel with CELLINK's "BIO X." The bio-printed heart cells were cultured for 7 to 14 days until they developed into pulsating patches of heart tissue. During open-heart surgery on mice from which the cells were derived, the vascularized heart patches were transplanted into the damaged areas of the heart. The transplantation aimed to test the safety of the bio-printed patches and confirm their positive effects on heart function, both of which were validated. [Summary] - Facility: Dr. Carmine Gentile's laboratory in Sydney - Challenge: Development of bio-printed heart tissue - Results: - Safety of the bio-printed patches - Positive effects on heart function *For more details, please refer to the related links or feel free to contact us.*

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Pursuing ease of use! Enables high-resolution printing using living cells.

The "BIONOVA X" is a type of bio 3D printer that cures hydrogels using DLP light crosslinking. It has a high resolution of about 10μm and also supports grayscale printing (changing the illumination according to the pixel intensity in the model image). Developed in the lab of Dr. Shaochen Chen at UCSD, this device accommodates a variety of applications and can be applied to the development of axonal guides for spinal injury treatment. 【Features】 ■ Can print directly onto well plates with up to 24 wells ■ Provides an ideal environment for high-throughput applications ■ Capable of easily modeling tiny structures and complex shapes such as vascular systems ■ Patented continuous printing technology ■ Achieves overwhelming speed without sacrificing print fidelity *For more details, please refer to the related links or feel free to contact us.

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We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will introduce a number of products, including our new product, the Pillow Packaging Full Air Tightness Inspection Machine MSQ-2003. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to visit us at this opportunity. 【 Exhibition Name 】 JAPAN PACK 2025 Japan Packaging Industry Exhibition https://www.japanpack.jp/ 【 Dates 】 October 7 (Tuesday) to October 10 (Friday), 2025 *4 days 10:00 AM to 5:00 PM 【 Venue / Booth Number 】 Tokyo Big Sight / East Hall 8, Booth 8-505

[Speaker] Hajime Hiraki, CEO of Chemistry Cube Co., Ltd., Innovation Consultant [Key Lecture Content] Until now, in many companies, managers who operate and manage organizations and specialists in specific technical fields have been established as the career paths for engineers and researchers. However, as uncertainty increases, there is a growing demand for value creation capabilities that anticipate societal challenges and customer needs and generate innovation. In this context, the importance of a new career path, "Technical Leader," distinct from traditional managers and specialists, is on the rise. In this lecture, we will focus on the "Technical Leader," who plays a central role in value creation centered on technology, and explain their role, the required abilities, and the approach to their development, using case studies. [Lecture Items] 1. The Era of Technical Leaders 2. What is a Technical Leader? 3. Practicing Technical Leadership - Management Techniques for Technical Leaders 4. Development of Technical Leaders 5. Q&A / Business Card Exchange

[Lecture Topics] 1. Smart City Policies by the Cabinet Office Yusuke Nakamura, Planning Officer, Cabinet Office, Science and Technology Innovation Promotion Secretariat 1. Policy Positioning of Smart Cities 2. Smart City Policies of the Cabinet Office 3. Revision of SCRA 4. Q&A / Business Card Exchange 2. Digital Policies of the Ministry of Internal Affairs and Communications Promoting Community DX Tatsuhiko Saruta, Deputy Director (Smart City and Subsidy Projects), Digital Economy Promotion Office, Information and Communications Bureau, Ministry of Internal Affairs and Communications 1. Current Status and Challenges of Local Communities 2. Expected Roles of Digital Technology and Strategies for Problem Solving 3. Status of Initiatives in FY R7 by the Ministry of Internal Affairs and Communications 4. Future Initiatives 5. Q&A / Business Card Exchange 3. Initiatives for Promoting Smart Cities by the Ministry of Land, Infrastructure, Transport and Tourism Masahiro Kobayashi, Planning Specialist, Digital Information Utilization Promotion Office, International and Digital Policy Division, Urban Bureau, Ministry of Land, Infrastructure, Transport and Tourism 1. Initiatives to Promote the Spread of Smart Cities 2. Urban Development DX and Project PLATEAU 3. Q&A / Business Card Exchange

[Speaker] Toru Kumagai, Journalist from Germany [Lecture Topics] 1. The German government holds a summit meeting to support the automotive industry 2. Will the EU change the ban on new internal combustion engine vehicle sales by 2035? 3. The main players at the Munich Auto Show IAA Mobility are China and BEVs 4. The strategy of Chinese OEMs steadily expanding their foothold in Europe 5. Reasons for the recovery of new BEV registrations in Europe by 2025 6. Is the hollowing out of the German automotive industry progressing due to Trump tariffs? 7. Q&A

We will be exhibiting at "BioJapan 2025." We would like to invite you to visit our booth. All of our staff are sincerely looking forward to your visit. ■ Booth Number: D-69 ■ Exhibitor Website https://biojapan2025.jcdbizmatch.jp/Lookup/jp/Member/u0?ke=%E9%96%A2%E6%9D%B1%E5%8C%96%E5%AD%A6&np=2&ob=1&ub=1 ■ Exhibition Content: Manufacturing services for cell culture media and preparation solutions, reagents related to regenerative medicine (such as the ciKIC series), reagents related to cell assays (such as the ad-MED Vitrogel series), etc.