Notice of participation in the 24th Annual Meeting of the Japanese Society for Regenerative Medicine from March 20 (Thursday) to March 22 (Saturday), 2025.

Reduce the risk of inflow and outflow of pollutants. Comprehensive support for facility development.

The "Room Pressure Control System" is our patented system (Patent No. 6773364) that allows for the sealing of decontamination rooms without disrupting the pressure balance with adjacent rooms in the same air conditioning system. By implementing this system, it is no longer necessary to stop the entire air conditioning system every time decontamination occurs, even in highly airtight rooms like cleanrooms, which also helps reduce the risk of contamination inflow and outflow. Additionally, our company can provide comprehensive support from planning to construction and maintenance for life science facilities such as pharmaceutical manufacturing facilities. [Our Strengths] - Proposals based on advanced technology grounded in experience and achievements, considering the entire equipment system. - We can also propose facility construction in compliance with the Pharmaceuticals and Medical Devices Act and the Act on Securing Safety for Regenerative Medicine. - Flexible responses to advanced needs such as room pressure management and aseptic management. *For more information about our company, please refer to the materials. Feel free to contact us as well.

• Pressure Control

For those considering the establishment or renovation of research facilities such as pharmaceutical manufacturing and cell culture processing, please feel free to consult with us! 【*Project examples are currently available.】

Our company plans, designs, and constructs clean rooms and related facilities under various conditions, ranging from life science facilities to medical facilities. By utilizing "digital mockups," we conduct virtual walkthroughs that allow us to visualize the flow of people and materials within the facility. You can confirm the 3D image of what the building will look like upon completion. This enables us to clearly envision detailed points that may only become apparent after completion (for example, "the workspace is good, but the changing area turned out to be surprisingly small," or "it became dark due to shadows from objects," etc.). [Features] - By utilizing digital mockups, you can virtually confirm the flow and completion image. - We propose facilities that comply with GMP, from flow planning to quality assurance. - We accommodate not only new constructions but also maintenance and renovations after operation. *For more details, please download the PDF or feel free to contact us.

• Other clean room equipment and facilities

Acquisition of a patent for "room pressure control technology" for cell culture processing facilities and establishment of a model room.

Our company plans, designs, and constructs clean rooms and related facilities under various conditions, ranging from life science facilities to medical facilities. We have obtained a patent for "room pressure control technology," which allows us to seal a decontamination room while maintaining pressure balance with adjacent rooms. In the model room established at our Tsukuba Mirai Technology Center, we can conduct tests on room pressure control for bio clean rooms, such as cell culture processing facilities. Additionally, we possess advanced technology and extensive know-how for the establishment and renovation of clean rooms in pharmaceutical manufacturing facilities and cell culture processing facilities, including "digital mock-up technology," which allows for virtual confirmation of the interior before construction. Please feel free to consult with us! For more details, such as case studies of cell culture processing facilities, please download the PDF or feel free to contact us.

• Clean Room

Improved workability with handle opening and closing while maintaining high airtightness.

This product is a high airtight super pass box that employs electromagnetic locks on the doors to prevent contamination during the loading and unloading of items into and out of clean rooms, eliminating the risk of simultaneous opening. During the decontamination of CPC, the doors are further secured to enhance airtightness. Additionally, the 15W UV lamps will turn off when the doors are open. 【Features】 ■ The interior of the pass box is decontaminated by UV lamps (automatic shut-off setting). ■ When the interlock is released, a buzzer on the receiving side sounds to indicate that the door is open. ■ When the door is closed, the interlock turns ON and the buzzer stops. *For more details, please download the PDF or feel free to contact us.

• Other clean room equipment and facilities

We will be exhibiting at the "12th Conference of the Advanced Power Semiconductor Subcommittee" held at the Toyama International Conference Center. We will be introducing our latest analysis technology services, so please stop by! We sincerely look forward to your visit.

Our company will exhibit at the Measurement and Measurement Comprehensive Technology Exhibition in Hokuriku, showcasing safety products with Gemba Reporter. Please be sure to stop by booth number "72" when you visit. 【Date and Time】 November 6, 2025 (Thursday) 9:00 AM - 5:00 PM 【Venue】 Ishikawa Industrial Exhibition Hall, Building 2 From JR Kanazawa Station, take the Hokutetsu Bus bound for "Shimo-Yasuhara" and get off at "Fukurobatake Town West Green Park," then walk for 5 minutes. Alternatively, take the Hokutetsu Bus bound for "Saiseikai Hospital," get off at "Seibu Green Park," and it will take about 15 minutes by taxi. 【Materials】 https://www.line.co.jp/wp-content/uploads/2025/10/MepTechhokuriku2025.pdf 【Notes】 Please register in advance using the 2D barcode in the PDF.

Sekiguchi Iron Works Co., Ltd. will exhibit at the "Environmental Industry Expo 2025" held at S-Bird in Iida City, Nagano Prefecture. This exhibition aims to pave the way for a sustainable future from the local community. It is a trade fair for environmental-related industries originating from the Minami-Shinshu region of Nagano Prefecture. Our company will introduce next-generation solutions for reducing environmental impact and effectively utilizing energy, including our "smokeless small incinerator" and "stove," along with product panels and case studies. No pre-registration is required, and admission is free. We sincerely look forward to your visit.

Recently, fine bubbles, which are tiny bubbles smaller than 100 μm and are referred to as "fine bubbles," have attracted attention in various fields such as the environment, agriculture, food, fisheries, and medicine, due to their ability to impart various functions to liquids. Fine bubbles are classified into two types based on their size: microbubbles and ultrafine bubbles. Recently, there has been a growing interest in ultrafine bubbles, which have a lifespan of several weeks to months. However, listening to the voices of researchers and users reveals some skepticism, which has become one of the issues hindering the spread of fine bubble technology. On the other hand, we have challenged the elucidation of the stabilization mechanism of ultrafine bubbles from a new perspective by enabling the control of number density exceeding 10 billion particles/mL without pressure or concentration operations using our ultrafine bubble generation technology. In this seminar, we will provide a fundamental explanation of fine bubble technology, including the basic physical properties, characteristics and functions, device technology, measurement and evaluation methods, and case studies, to promote research and utilization of fine bubbles based on a correct understanding.

Sekiguchi Iron Works Co., Ltd. will exhibit at the "Minami-Shinshu Environmental Messe 2025" held at S-Bird in Iida City, Nagano Prefecture. This exhibition will be held simultaneously with the "Environmental Industry Trade Fair" taking place the day before. It will be held over the weekend, with many family-friendly events planned. We encourage those who usually find it difficult to visit to take this opportunity to come. Our product exhibition area is located about 10 minutes from the venue. We sincerely look forward to your visit.