Notice of participation in the 24th Annual Meeting of the Japanese Society for Regenerative Medicine from March 20 (Thursday) to March 22 (Saturday), 2025.

Reduce the risk of inflow and outflow of pollutants. Comprehensive support for facility development.

The "Room Pressure Control System" is our patented system (Patent No. 6773364) that allows for the sealing of decontamination rooms without disrupting the pressure balance with adjacent rooms in the same air conditioning system. By implementing this system, it is no longer necessary to stop the entire air conditioning system every time decontamination occurs, even in highly airtight rooms like cleanrooms, which also helps reduce the risk of contamination inflow and outflow. Additionally, our company can provide comprehensive support from planning to construction and maintenance for life science facilities such as pharmaceutical manufacturing facilities. [Our Strengths] - Proposals based on advanced technology grounded in experience and achievements, considering the entire equipment system. - We can also propose facility construction in compliance with the Pharmaceuticals and Medical Devices Act and the Act on Securing Safety for Regenerative Medicine. - Flexible responses to advanced needs such as room pressure management and aseptic management. *For more information about our company, please refer to the materials. Feel free to contact us as well.

• Pressure Control

For those considering the establishment or renovation of research facilities such as pharmaceutical manufacturing and cell culture processing, please feel free to consult with us! 【*Project examples are currently available.】

Our company plans, designs, and constructs clean rooms and related facilities under various conditions, ranging from life science facilities to medical facilities. By utilizing "digital mockups," we conduct virtual walkthroughs that allow us to visualize the flow of people and materials within the facility. You can confirm the 3D image of what the building will look like upon completion. This enables us to clearly envision detailed points that may only become apparent after completion (for example, "the workspace is good, but the changing area turned out to be surprisingly small," or "it became dark due to shadows from objects," etc.). [Features] - By utilizing digital mockups, you can virtually confirm the flow and completion image. - We propose facilities that comply with GMP, from flow planning to quality assurance. - We accommodate not only new constructions but also maintenance and renovations after operation. *For more details, please download the PDF or feel free to contact us.

• Other clean room equipment and facilities

Acquisition of a patent for "room pressure control technology" for cell culture processing facilities and establishment of a model room.

Our company plans, designs, and constructs clean rooms and related facilities under various conditions, ranging from life science facilities to medical facilities. We have obtained a patent for "room pressure control technology," which allows us to seal a decontamination room while maintaining pressure balance with adjacent rooms. In the model room established at our Tsukuba Mirai Technology Center, we can conduct tests on room pressure control for bio clean rooms, such as cell culture processing facilities. Additionally, we possess advanced technology and extensive know-how for the establishment and renovation of clean rooms in pharmaceutical manufacturing facilities and cell culture processing facilities, including "digital mock-up technology," which allows for virtual confirmation of the interior before construction. Please feel free to consult with us! For more details, such as case studies of cell culture processing facilities, please download the PDF or feel free to contact us.

• Clean Room

Improved workability with handle opening and closing while maintaining high airtightness.

This product is a high airtight super pass box that employs electromagnetic locks on the doors to prevent contamination during the loading and unloading of items into and out of clean rooms, eliminating the risk of simultaneous opening. During the decontamination of CPC, the doors are further secured to enhance airtightness. Additionally, the 15W UV lamps will turn off when the doors are open. 【Features】 ■ The interior of the pass box is decontaminated by UV lamps (automatic shut-off setting). ■ When the interlock is released, a buzzer on the receiving side sounds to indicate that the door is open. ■ When the door is closed, the interlock turns ON and the buzzer stops. *For more details, please download the PDF or feel free to contact us.

• Other clean room equipment and facilities

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will introduce a number of products, including our new product, the Pillow Packaging Full Air Tightness Inspection Machine MSQ-2003. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to visit us at this opportunity. 【 Exhibition Name 】 JAPAN PACK 2025 Japan Packaging Industry Exhibition https://www.japanpack.jp/ 【 Dates 】 October 7 (Tuesday) to October 10 (Friday), 2025 *4 days 10:00 AM to 5:00 PM 【 Venue / Booth Number 】 Tokyo Big Sight / East Hall 8, Booth 8-505

Nitto Kohki will hold the "2024 Attack Fair in Ichihara" at the "Yume Hall" for two days from December 11 (Wednesday) to December 12 (Thursday), 2024. The Attack Fair is an exhibition where you can actually "see, touch, and operate" Nitto Kohki's products. Additionally, there will be wonderful souvenirs for visitors and many fun activities prepared. We look forward to welcoming everyone!

Nitto Kohki will hold the "2025 Attack Fair in Kurume" at the "Local Production Kurume General Exhibition Hall" for two days from February 13 (Thursday) to February 14 (Friday), 2025. The Attack Fair is an exhibition where you can actually "see, touch, and operate" Nitto Kohki's products. Additionally, there will be wonderful commemorative gifts for visitors and many fun activities prepared. We look forward to welcoming everyone!

**Seminar Overview** The construction industry faces many challenges, including a shortage of personnel, regulations on maximum working hours, and the need for efficiency improvements. Additionally, the transmission of skills due to an aging workforce has become a significant issue, with a high turnover rate among younger employees who are supposed to carry on these skills. In this seminar, we will discuss the causes of turnover based on case studies and explain key points on how to reduce turnover rates by advancing IT integration.

**Seminar Overview** "Generative AI," which is gaining attention as a method for improving business efficiency and utilizing internal digital transformation (DX), can be influenced by the literacy of the employees using it, potentially increasing the burden of work instead. In this seminar, we will discuss the current challenges of generative AI while providing examples of how it can be used to enhance business efficiency. We will also explain how to utilize generative AI in a way that achieves efficiency without being dependent on the user's skills. We hope this will serve as a reference for considering the use of generative AI.