[Exhibition Information] 34th Annual Meeting of the Japanese Society of Circulatory Pharmacology

A world-class patch clamp system that is easy to operate for anyone, allowing for simple data acquisition and verification.

This is a patch clamp system of the world's smallest class that can perform gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. 【Features】 ■ No need for manual patch clamp experience or difficult operations ■ No need for microscope, vibration table, manipulator, Faraday cage, or puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent, ligand-dependent, and temperature-dependent channels ■ Options available for research on channel rhodopsins and mechanosensitive channels using light stimulation ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications and enables rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips ■ Optional temperature control (10 to 50°C), capable of extracellular/intracellular perfusion ■ Can be integrated with amplifiers such as HEKA and Axon *For details, please refer to the catalog available for download in PDF.

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

Measurement of impedance and extracellular potential of iPS-derived cardiomyocytes.

This is a hybrid cardiotoxicity screening device capable of impedance measurement and extracellular potential measurement similar to MEA. It can detect not only cardiomyocytes but also the minute contractions of cancer cells and liver cells due to the effects of compounds. ■ Simultaneous measurement of impedance and extracellular potential ■ 96-well simultaneous measurement ■ Label-free measurement ■ Long-term monitoring capability ■ Electrical pacing & optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, and CO2 control) ■ Includes multifunctional and excellent data analysis and graph creation software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

The Langeendorff method has been transformed into the latest high-throughput technology, allowing for the measurement of contractile force in cardiomyocytes under physiological conditions similar to the natural environment of cardiac tissue.

The FLEXcyte 96, which transforms the conventional Langendorff method into the latest high-throughput technology, can measure the contractile force (mN/mm²) of cardiomyocytes for cardiotoxicity and safety evaluation, as well as drug screening, under physiological conditions similar to the native cardiac tissue environment, without missing even slight responses to cytotoxicity, regardless of whether in the chronic or acute phase, simultaneously in 96 wells. ■ Simultaneous measurement in 96 wells ■ Label-free measurement ■ Long-term monitoring possible ■ Optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, CO2 control) ■ Includes multifunctional excellent data analysis and graphing software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

Under physiological conditions, it is possible to measure the actual contractile force of iPS-derived cardiomyocytes.

Measurement of Contraction Force in Cardiomyocytes Using FLEXcyte96 The FLEXcyte membrane plate features a silicon membrane with a thickness of less than 10μm at the bottom of a 96-well plate. When cardiomyocytes are seeded onto the plate, the weight of the culture medium causes the silicon membrane to deflect, and subsequently, dynamic deflection (up and down movement) occurs due to the synchronized beating of the cardiomyocytes. By measuring the changes in deflection with our proprietary Capacitive Distance Sensor, developed in collaboration with innoVitro, it is possible to calculate mechanical stress and measure the actual contraction force under physiological conditions.

• Other physicochemical equipment
• Other Analysis

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to attend this event. 【 Exhibition Name 】 27th INTERPHEX Week Tokyo https://www.interphex.jp/tokyo/ja-jp.html 【 Dates 】 July 9 (Wednesday) - 11 (Friday), 2025 10:00 AM - 5:00 PM 【 Venue 】 Tokyo Big Sight (3-11-1 Ariake, Koto-ku, Tokyo 135-0063)

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely invite you to visit us during this busy time. 【 Exhibition Name 】 Automotive Technology Exhibition 2025 YOKOHAMA https://aee.expo-info.jsae.or.jp/ja/yokohama/ (An "online exhibition" will also be held during and around the event period) 【 Dates 】 May 21 (Wednesday) - 23 (Friday), 2024 10:00 AM - 6:00 PM *On the final day, 9:00 AM - 4:00 PM (Online exhibition: May 14 (Wednesday) - June 4 (Wednesday)) 【 Venue 】 Pacifico Yokohama (1-1-1 Minatomirai, Nishi-ku, Yokohama, Kanagawa Prefecture) Our booth number: "Concourse 505"

Nakakin will be exhibiting at 'FOOMA JAPAN 2026 (International Food Industry Exhibition)' held at Tokyo Big Sight. This exhibition proposes "A rich future opened by food technology" through cutting-edge technology, products, and services in food machinery, amidst growing interest in "food safety and security." We aim to facilitate the exchange and dissemination of technology and information related to food machinery, equipment, and associated devices, contributing to the further development of the food industry. We sincerely look forward to your visit.

[Speaker] Academic Visitor, University of Strathclyde, UK Visiting Professor, Offshore Wind Research and Education Center, Kyushu University Senior Researcher, Institute for Sustainable Energy Policies (ISEP) Mr. Yo Yasuda [Lecture Topics] 1. International Trends in Decarbonization and Japan's Position (1) Risks of Fossil Fuel Dependence and Decarbonization as Risk Management (2) Discussions on Decarbonization and Renewable Energy in International Organizations (3) Discussions on Decarbonization and Renewable Energy in Japan (4) Discrepancies Between International and Domestic Discussions (The U.S. is not the world) 2. International Discussions on Large-Scale Introduction of Renewable Energy (1) Electrification and Sector Coupling (Why are EVs and Heat Pumps Advancing?) (2) Externalities and Benefits (Long-Term Perspective and Risk Management) (3) Flexibility (The notion that "renewable energy is unstable" is outdated) 3. Challenges and Solutions for Japan, Methodology for Information Gathering (1) Fake News and Scientific Methodology (2) Non-Scientific Narratives and Evidence-Based Policy Making (EBMP) (3) AI and Specialized Information Retrieval 4. Q&A / Business Card Exchange *Reference: "The Future of 90% Renewable Energy by 2050 - Scenarios and Scientific Basis for Achieving Decarbonization" by Yo Yasuda, Yamato Keikokusha (December 2024)

[Speaker] Akira Yamauchi, President and CEO of Intellectual Property Landscape Co., Ltd. Patent Attorney, AIPE Certified Senior Intellectual Property Analyst [Lecture Topics] 1. What is Physical AI? [1] Industrial Robots [2] Humanoids [3] Autonomous Vehicles as the main fields Overview of the population setting for the three fields and the key players in each field 2. [1] Industrial Robot Analysis 3. [2] Humanoid Analysis 4. [3] Autonomous Vehicle Analysis 5. Summary and Discussion of the Analysis Results for the Three Fields 6. Q&A Session