[Exhibition Information] 16th Annual Meeting of the Japanese Society of Safety Pharmacology

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

No pipetting operations are required during the experiment. It is equipped with a benchtop dispensing device that can automatically measure up to 48 cells continuously in an auto patch clamp system.

This is a tabletop-sized auto patch clamp system that can simultaneously measure up to 8 cells with giga-seal formation. With easy experimental setup, stable whole-cell recordings, and sophisticated software, it enables highly efficient compound ion channel screening. ■ Equipped with a dispensing device, allowing for fully automated experiments (measurements) ■ Simultaneous measurement of 4 cells / 8 cells (up to 48 cells can be measured continuously) ■ 250 to 600 data points per day ■ Automation from giga-seal formation to whole-cell formation ■ Compatible with voltage-dependent and ligand-dependent channels ■ Measurement of action potentials using current clamp is also possible ■ Dynamic clamp capability (optional) ■ Temperature control and extracellular/intracellular perfusion possible ■ Cooling plate allows for cooling of cells and compounds ■ Borosilicate glass chips reduce compound adsorption ■ Comes with excellent analysis software

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

An automated patch clamp system capable of meeting all needs, from small-scale screening projects to high-throughput screening.

Designed to seamlessly integrate fully automated compound screening into the drug discovery process, it provides the best performance in high-throughput screening of ion channels in drug discovery, pharmacology, safety, pharmaceutical research and development, and exploratory screening departments. Additionally, by using the 32-well mode, it can be optimized for small-scale compound screening and projects. ■ Simultaneous measurement of 384 cells ■ 20,000 data points per day ■ High giga-seal success rate ■ Supports a variety of ion channel targets and enables rapid assay system development ■ Measurement of action potentials using current clamp is also possible ■ Extracellular/intracellular perfusion is possible ■ High-speed external solution exchange (up to 110 µl/s) is possible ■ Measurement section and 12 decks can be individually temperature controlled (temperature range: 10–37°C) ■ Compound plate preparation on the deck is possible ■ Single & multi-well chips available (in-house manufactured) ■ Borosilicate glass chips reduce compound adsorption ■ Approximately 8 hours of unmanned operation is possible ■ Comes with powerful analysis software ■ Validated system for CiPA

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

The Langeendorff method has been transformed into the latest high-throughput technology, allowing for the measurement of contractile force in cardiomyocytes under physiological conditions similar to the natural environment of cardiac tissue.

The FLEXcyte 96, which transforms the conventional Langendorff method into the latest high-throughput technology, can measure the contractile force (mN/mm²) of cardiomyocytes for cardiotoxicity and safety evaluation, as well as drug screening, under physiological conditions similar to the native cardiac tissue environment, without missing even slight responses to cytotoxicity, regardless of whether in the chronic or acute phase, simultaneously in 96 wells. ■ Simultaneous measurement in 96 wells ■ Label-free measurement ■ Long-term monitoring possible ■ Optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, CO2 control) ■ Includes multifunctional excellent data analysis and graphing software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

Measurement of impedance and extracellular potential of iPS-derived cardiomyocytes.

This is a hybrid cardiotoxicity screening device capable of impedance measurement and extracellular potential measurement similar to MEA. It can detect not only cardiomyocytes but also the minute contractions of cancer cells and liver cells due to the effects of compounds. ■ Simultaneous measurement of impedance and extracellular potential ■ 96-well simultaneous measurement ■ Label-free measurement ■ Long-term monitoring capability ■ Electrical pacing & optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, and CO2 control) ■ Includes multifunctional and excellent data analysis and graph creation software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

Label-free and real-time high-throughput cell kinetics measurement is possible.

【Application Examples】 CAR-T cell killing assays, cell proliferation (viability), cytotoxicity (damage), biological barrier function, cell signaling, GPCR measurements, etc. AtlaZ can measure and analyze the impedance changes of cells in up to 6 x 96-well plates in real-time. Since it allows for daily kinetics measurements while remaining in the incubator, a single assay can yield a wealth of data regarding cell responses. Additionally, by changing the measurement frequency range, it can be applied to various applications. ■ Simultaneous measurement of up to 6 x 96-well plates (independent measurements are also possible) ■ Daily kinetics measurements are possible ■ A wide measurement range through frequency range adjustments | Frequency range (0.1 kHz to 100 kHz) ■ Selectable measurement modes (TEER, Cell Monitoring, Cytolysis mode) (Measurements with different functions for each plate are also possible) ■ Management of measurement plates is possible with the included barcode scanner.

• Other physicochemical equipment
• Other Analysis

We are pleased to announce that we will be exhibiting at the exhibition "TOYO One-Man Show 2026" hosted by Toyo, as detailed below. We regularly share information on our website and various social media platforms, but this will be a great opportunity for you to see the actual measuring instruments. We sincerely invite you to attend. Date: January 28 (Wed) and 29 (Thu), 2026, from 10:00 AM to 8:00 PM Venue: Kariya City Industrial Promotion Center (1-1-6 Aioi-cho, Kariya City, Aichi Prefecture, a 5-minute walk from JR Kariya Station) Exhibiting manufacturers: Approximately 75 companies Registration URL: https://www.tenjikai-uketsuke.com/form/toyo-show2026/visitor *Please note that pre-registration is required, so we kindly ask you to register in advance via the web.

Do you want to use SOLIDWORKS more conveniently but think, "API seems difficult..."? How about trying to create a macro together? The theme is "Automating just one process." This time, we will create a system that automates the simple task of "saving," which you do manually every time in SOLIDWORKS, so that it can be completed with one click. Even if you have never written code before, that's okay. By simply "tracing and creating together" the necessary parts, you will be able to experience the excitement of actual automation in action. Through this webinar, I hope you will realize, "Oh, I can start with something this small in API." ■ Recommended for: - Those who do not fully understand how to utilize SOLIDWORKS API - Those who are not familiar with macros - Those who want to automate their design processes - Those who want to reduce human errors, even just a little.

[Speaker] Associate Professor Naoshi Matsuhisa, Center for Advanced Science and Technology, The University of Tokyo [Key Lecture Content] Various soft and stretchable electronic materials that break the common belief that rubber does not conduct electricity are being developed. Electronics made with these materials are expected to be utilized as next-generation wearable devices that are soft like skin, provide excellent wearing comfort, and enable long-term health monitoring. This lecture will introduce the forefront of soft and stretchable electronic material development, as well as the creation of entirely new healthcare human-computer interfaces that integrate with the skin. [Lecture Items] 1. Soft and stretchable electronics 2. Ultra-flexible electronics that accompany people 3. The forefront of diverse stretchable electronic material development 4. Sensors and displays that integrate with the skin 5. Ultra-flexible semiconductor devices using stretchable semiconductor materials 6. Next-generation wearable devices that integrate with the skin 7. Summary 8. Q&A / Business card exchange

[Lecturer] Yoshiaki Otsuki, Special Counsel, Anderson Mori & Tomotsune Law Office, Foreign Law Joint Enterprise [Key Lecture Content] Rare earth elements are metallic minerals commonly used in electric vehicles (EVs) and smartphones, but it is said that a large portion of their production relies on China. However, in light of the recent intensification of U.S.-China tensions and other international circumstances, concerns have arisen regarding the security of rare earth supply. In this context, the development of rare earth projects within Japan's territorial waters or exclusive economic zone (EEZ) has suddenly come into the spotlight. This lecture will focus on the legal aspects of rare earth development projects within Japan's territory, particularly addressing the application issues of the Mining Act, which was amended in 2022. [Lecture Topics] Chapter 1: Introduction - International Situation Surrounding Rare Earths Chapter 2: Application of the Mining Act Regarding Rare Earth Development in Japan's Territory Chapter 3: Future Outlook Q&A / Business Card Exchange

[Speaker] Mr. Daiki Kaneda, President and CEO of AXIA Marketing Co., Ltd. Mr. Atsushi Nagata, Director [Key Lecture Content] With the rise of manufacturers from emerging countries, the modern era is reaching its limits in competition based solely on specifications and price. The key for Japanese manufacturing industries, such as automotive parts, industrial machinery, semiconductors, chemicals, and steel, to regain growth in the global market lies in a "deep understanding of local technology trends and regulations" and a strategy that "avoids falling too deeply into price competition and transforms into added value." In this lecture, we will explain, using specific examples, how to avoid and leverage the latest local needs and pressures of technology transfer, and how to earn trust. [Lecture Topics] 1. The harsh reality of the global market and the redefinition of "reasons to be chosen." 2. Development strategies to break through the pressures of technology transfer and institutional barriers. 3. Game-changing material selection: the forefront of decarbonization and ESG compliance. 4. Learning from successful cases: a roadmap for market development and a "key" to execution. 5. Q&A session.