[Exhibition Information] 16th Annual Meeting of the Japanese Society of Safety Pharmacology

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

No pipetting operations are required during the experiment. It is equipped with a benchtop dispensing device that can automatically measure up to 48 cells continuously in an auto patch clamp system.

This is a tabletop-sized auto patch clamp system that can simultaneously measure up to 8 cells with giga-seal formation. With easy experimental setup, stable whole-cell recordings, and sophisticated software, it enables highly efficient compound ion channel screening. ■ Equipped with a dispensing device, allowing for fully automated experiments (measurements) ■ Simultaneous measurement of 4 cells / 8 cells (up to 48 cells can be measured continuously) ■ 250 to 600 data points per day ■ Automation from giga-seal formation to whole-cell formation ■ Compatible with voltage-dependent and ligand-dependent channels ■ Measurement of action potentials using current clamp is also possible ■ Dynamic clamp capability (optional) ■ Temperature control and extracellular/intracellular perfusion possible ■ Cooling plate allows for cooling of cells and compounds ■ Borosilicate glass chips reduce compound adsorption ■ Comes with excellent analysis software

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

An automated patch clamp system capable of meeting all needs, from small-scale screening projects to high-throughput screening.

Designed to seamlessly integrate fully automated compound screening into the drug discovery process, it provides the best performance in high-throughput screening of ion channels in drug discovery, pharmacology, safety, pharmaceutical research and development, and exploratory screening departments. Additionally, by using the 32-well mode, it can be optimized for small-scale compound screening and projects. ■ Simultaneous measurement of 384 cells ■ 20,000 data points per day ■ High giga-seal success rate ■ Supports a variety of ion channel targets and enables rapid assay system development ■ Measurement of action potentials using current clamp is also possible ■ Extracellular/intracellular perfusion is possible ■ High-speed external solution exchange (up to 110 µl/s) is possible ■ Measurement section and 12 decks can be individually temperature controlled (temperature range: 10–37°C) ■ Compound plate preparation on the deck is possible ■ Single & multi-well chips available (in-house manufactured) ■ Borosilicate glass chips reduce compound adsorption ■ Approximately 8 hours of unmanned operation is possible ■ Comes with powerful analysis software ■ Validated system for CiPA

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

The Langeendorff method has been transformed into the latest high-throughput technology, allowing for the measurement of contractile force in cardiomyocytes under physiological conditions similar to the natural environment of cardiac tissue.

The FLEXcyte 96, which transforms the conventional Langendorff method into the latest high-throughput technology, can measure the contractile force (mN/mm²) of cardiomyocytes for cardiotoxicity and safety evaluation, as well as drug screening, under physiological conditions similar to the native cardiac tissue environment, without missing even slight responses to cytotoxicity, regardless of whether in the chronic or acute phase, simultaneously in 96 wells. ■ Simultaneous measurement in 96 wells ■ Label-free measurement ■ Long-term monitoring possible ■ Optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, CO2 control) ■ Includes multifunctional excellent data analysis and graphing software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

Measurement of impedance and extracellular potential of iPS-derived cardiomyocytes.

This is a hybrid cardiotoxicity screening device capable of impedance measurement and extracellular potential measurement similar to MEA. It can detect not only cardiomyocytes but also the minute contractions of cancer cells and liver cells due to the effects of compounds. ■ Simultaneous measurement of impedance and extracellular potential ■ 96-well simultaneous measurement ■ Label-free measurement ■ Long-term monitoring capability ■ Electrical pacing & optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, and CO2 control) ■ Includes multifunctional and excellent data analysis and graph creation software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

Label-free and real-time high-throughput cell kinetics measurement is possible.

【Application Examples】 CAR-T cell killing assays, cell proliferation (viability), cytotoxicity (damage), biological barrier function, cell signaling, GPCR measurements, etc. AtlaZ can measure and analyze the impedance changes of cells in up to 6 x 96-well plates in real-time. Since it allows for daily kinetics measurements while remaining in the incubator, a single assay can yield a wealth of data regarding cell responses. Additionally, by changing the measurement frequency range, it can be applied to various applications. ■ Simultaneous measurement of up to 6 x 96-well plates (independent measurements are also possible) ■ Daily kinetics measurements are possible ■ A wide measurement range through frequency range adjustments | Frequency range (0.1 kHz to 100 kHz) ■ Selectable measurement modes (TEER, Cell Monitoring, Cytolysis mode) (Measurements with different functions for each plate are also possible) ■ Management of measurement plates is possible with the included barcode scanner.

• Other physicochemical equipment
• Other Analysis

Softex Corporation will be exhibiting at the "40th Electro Test Japan" held at Tokyo Big Sight. At our booth, we will showcase the micro-focus X-ray inclined CT inspection device "SHRα," which demonstrates its power on components such as implemented multilayer boards and three-dimensional structures that have been difficult to inspect until now. [Booth Number: East Hall 5 E15-17] We sincerely look forward to your visit.

Kanadebia Co., Ltd. will be exhibiting at the "9th Railway Technology Exhibition 2025 Mass-Trans Innovation Japan 2025" held at Makuhari Messe. This exhibition has been held since 2010 as a comprehensive trade fair where various railway-related technologies, including railway and transportation systems, infrastructure technology, facilities, power, transportation, operation management, vehicles, interiors, and passenger services, come together. Please be sure to check out the "Railway Camera System" offered by Kanadebia. We sincerely look forward to your visit.

On November 20, 2025 (Thursday) and December 2, 2025 (Tuesday) from 11:00 to 14:00, our representative, certified public accountant and tax accountant Koichi Yokoyama, will be speaking at a free webinar hosted by Otsuka Shokai. He will explain important points to be aware of regarding the revised Construction Industry Law. [Construction Industry Law / Public Works Appropriateness Promotion Law] - Prevention of omissions in the description of construction contracts - Obligation to notify "risk" information before the contractor's contract - Mutual exchange of original documents for construction contracts - Digitization of estimates, contracts, and order forms/acceptance letters We are entering an era where contracts must be documented in writing and stored electronically. At Paperlogic, we fully support companies that are transitioning from paper to digital. We also offer free consultations with certified public accountants and tax accountants, so please join us!

We would like to inform you that we will be exhibiting our products at the Membrane Symposium 2025. If you are planning to attend, please feel free to stop by. ❚ Products Scheduled for Exhibition - Artificial Lipid Bilayer Experimental Device | Orbit mini You can easily measure channel activity at the single-molecule level. This device allows for the formation of lipid membranes, reconstitution of membrane proteins, and single-channel measurements in experiments using artificial lipid bilayers, all performed with just a micropipette, enabling functional and structural analysis of target membrane proteins and evaluation of drug effects. - Liposome Preparation Device | Vesicle Prep Pro This is the world's first device that can produce giant unilamellar vesicles (GUVs) with diameters ranging from 1 to 30 μm without organic solvents, using the electroporation method (vibrating hydrated lipid films in an alternating electric field). - Auto Patch Clamp System | Port-a-Patch mini This compact system eliminates the need for a microscope, vibration isolation table, manipulator, and Faraday cage, which are typically required for conventional patch clamp experiments. It allows for easy data acquisition and verification without the need for specialized skills or experience.

Agilent will be exhibiting at the "VACUUM 2025 Vacuum Exhibition"! At Agilent, we offer clean and quiet IDP dry scroll pumps, high-performance and high-compression TwisTorr turbo pumps, ion pumps and controllers optimized for UHV/XHV, and robust and reliable helium leak detectors. Leveraging the technology and expertise cultivated at Varian Vacuum, we respond to our customers' vacuum needs with the value of our products and support based on extensive experience and knowledge. Agilent's pumps, systems, and components enable cutting-edge research in physics, analytical instruments, and nanotechnology, and are also ideal for industrial processes. We invite you to visit the Agilent booth! 【Exhibition Information】 Date: December 3 (Wed) - 5 (Fri), 2025, 10:00 - 17:00 Venue: Tokyo Big Sight, South Hall 2 Booth Number: V-36