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  3. Unchained Labs (アンチェインドラブズ)
  4. [Free Webinar] Revolutionizing LNP Development: Smooth Technology Transfer for High-Speed and High-Precision Formulation Exploration and Manufacturing
SEMINAR_EVENT
  • May 20, 2025
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May 20, 2025

[Free Webinar] Revolutionizing LNP Development: Smooth Technology Transfer for High-Speed and High-Precision Formulation Exploration and Manufacturing

Unchained Labs (アンチェインドラブズ) Unchained Labs (アンチェインドラブズ)
**[Issue]** The evolution of LNPs is progressing more rapidly than ever, largely due to modifications in particle formulations. However, the formulations to be tested are complex in composition and involve a vast number of combinations, making large-scale screening difficult to achieve. Furthermore, there is the subsequent challenge of transferring to production. Evaluations are also required to be accurate, comprehensive, and high-throughput. **[Webinar Overview]** In this webinar, we will explain how our Sun series can accelerate the exploration and development of LNPs, based on the latest research findings and user case studies in LNP formulations. We will also introduce Stunner, which enables high-speed and accurate LNP evaluations.
Date and time Thursday, Oct 05, 2023
01:00 PM ~ 02:30 PM
Capital
Entry fee Free
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Protein and Nucleic Acid Quality Evaluation Device 'STUNNER'

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

  • Other protein analysis

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[Webinar] The Bright Future Brought by the Sun Series to LNP Formulations

Introducing the details of the newly launched LNP production and screening device.

Researchers of lipid nanoparticles (LNPs) spend a tremendous amount of time on screening, optimization, and scaling up experiments to achieve optimal performance, spot-on targeting, and controlled release of active pharmaceutical ingredients (APIs). Factors such as solubility, pH stability, payload release, and encapsulation all depend on particle size, shape, and structure. In other words, to obtain the right formulation, it is necessary to explore a vast number of formulation parameters and process parameters one by one, and even if a perfect formulation is found, scaling up usually means switching equipment and re-optimizing settings. In this webinar, we will introduce a platform, Sunny Suite, that can reduce the time spent on these LNP formulations. ■ Date and Time: February 26 (Monday) 14:00~ ■ Speaker: Yuji Senoo, Field Application Scientist, Unchained Labs, Inc. ■ Register here: https://unchainedlabs.zoom.us/webinar/register/3217065146675/WN_U1o3xQoZRAKHN-A-7b1yqg

  • Other protein analysis

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The "Sun Series" that covers the development of lipid nanoparticles from upstream to downstream.

Seamlessly transition from formulation condition screening to scale-up and GMP manufacturing. Accelerate LNP product development.

The development of lipid nanoparticles (LNPs) faces many challenges. The formulation, optimization, and scale-up for clinical trials are complex, costly, and a race against time. Our LNP solutions are designed to accelerate all steps of LNP synthesis and characterization. Sunscreen accelerates LNP formulation screening by reducing costs and time, generating up to 96 unique LNP formulations within 6 hours. Next, using Sunshine, you can develop, optimize, and scale up protocols with the appropriate formulations obtained from Sunscreen. When it comes to the clinical trial phase, Sunbather can accommodate LNP production in a GMP environment using the same processes and microfluidic chips (Sunny) utilized by Sunscreen and Sunshine. In this way, the Sun series allows for a seamless transition from screening formulation conditions to scale-up and GMP manufacturing, as they all use the same pumps and microchannel chips. *For product details, please download various materials.

  • Other Physics and Chemistry Equipment

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GMP-compliant lipid nanoparticle automatic synthesis system Sunbather

Accelerating formulation optimization for vaccine and pharmaceutical development.

The transition from LNP to GMP is a costly and complicated process. Typically, this requires switching equipment, using different flow paths and mixing devices, and essentially re-developing and re-validating everything that has been painstakingly done so far. With Sunbather, the transition to GMP can be done easily thanks to its recording features, interchangeable flow paths, and easily transferable design. Sunbather uses the same mixing process and protocols as the Sunscreen and Sunshine from the same Sun series, allowing for easy transition of adjusted formulation conditions to GMP. - Up to 1.8 L/h - Integrated inline dilution - Fully interchangeable flow paths - A wide variety of mixing devices - Software compliant with 21 CFR Part 11 - Process transferable from Sunshine

  • Other Physics and Chemistry Equipment

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Lipid nanoparticle automatic synthesis system Sunshine

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

  • Other Physics and Chemistry Equipment

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Automatic Synthesis and Screening System for Lipid Nanoparticles Sunscreen

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

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How Will Drawings, Sites, and Documents Change? The Reality of AI Implementation That Construction and Civil Engineering Companies Need to Know Right Now in 45 Minutes

  • NEW
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To construction and civil engineering companies looking for the "next" step in digitalization. This seminar will explain the currently trending topic of "AI utilization" in 45 minutes. We will clearly introduce the latest trends, specific case studies, and steps for implementation to address questions such as "What can AI do?" and "How can it be applied to our business?" Whether your company is already advancing in DX or is just starting to consider AI, you will find hints for improving operational efficiency. 【Schedule】 1: Company introduction and instructor introduction 2: Case studies of AI utilization in the construction and civil engineering industry 3: Convincing examples! Patterns of AI utilization in construction operations 4: Three steps to avoid failure in AI implementation 5: Q&A and closing remarks

Jul 01, 2026

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Digitalizing the veteran's expertise! Techniques for sharing know-how to enable young professionals to operate independently.

  • NEW
  • SEMINAR_EVENT

We will address the issue of young employees who, despite joining the company, leave due to reasons such as "there's no time to be taught," "I don't understand when I'm told to learn by watching," and "what is written and said varies depending on the project or person in charge." We propose a system that accumulates the know-how of veterans in AI and systems, allowing young employees to search for and solve problems on their own. 【Schedule】 1: Company introduction and instructor introduction 2: Reasons why technical inheritance is not progressing (lack of time, difficulty in verbalizing) 3: "Next-generation manual and know-how sharing methods" utilizing video and AI search 4: Examples of system construction to institutionalize technical inheritance 5: Q&A and closing remarks

Jul 01, 2026

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Technofrontier

【Exhibition Information】TECHNO-FRONTIER 2026 @ Tokyo Big Sight July 15 (Wed) - July 17 (Fri), 2026 10:00 AM - 5:00 PM

  • NEW
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We are pleased to announce that our company will be exhibiting at TECHNO-FRONTIER 2026, which will be held at Tokyo Big Sight from July 15 to 17, 2026. As an import trading company dealing with components such as transformers and DC/DC converters, we take pride in our wide range of product offerings. Each of these products is a high-quality device designed for specific applications, utilized in areas such as improving power supply efficiency and miniaturization. At our exhibition booth, you will be able to see these products in person, and we will provide detailed information about their performance and applications. We sincerely look forward to welcoming those interested in the miniaturization of power supplies.

Jun 29, 2026

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[Exhibition Information] 13th Labor Safety and Health Exhibition @ Tokyo Big Sight July 15 (Wed) - July 17 (Fri), 2026 10:00 AM - 5:00 PM

  • NEW
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We are pleased to announce that our company will be exhibiting at the 13th Occupational Safety and Health Exhibition, which will be held at Tokyo Big Sight from July 15 to 17, 2026. At our exhibition space, we will showcase safety products such as LED line lights, shock detection labels (Shock Watch), temperature management indicators, and industrial belt partitions. At our booth, you will have the opportunity to see these products in person and learn more about their performance and applications. We sincerely look forward to your visit.

Jun 29, 2026

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[Seminar] Basic Design of Human Resource Systems and Operational Considerations

  • NEW
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[Instructor] Takahisa Saito, Human Resources Consultant, Saito Social Insurance and Labor Office [Key Lecture Content] Human resource systems support the foundation of an organization. However, if the operation is neglected, the system itself will collapse. There are various systems, but among them, the "grade system, evaluation system, and wage system" can be considered the three major elements. We must design these three major elements with the operation in mind. In other words, it is important that the system is easy for management to operate. There is no need to overthink it. Additionally, as work style reforms progress, we must also consider the response to equal pay for equal work. I believe that what lies ahead after organizing the current situation is the "limited regular employee." In this seminar, we will share anticipated information and provide clear explanations. Furthermore, for those attending in person, meaningful information exchange is possible through questions and mutual confirmation. [Lecture Items] 1. Trends and Perspectives Surrounding Human Resources 2. Basics of the Grade System 3. Basics of the Evaluation System 4. Basics of the Wage System 5. Considering Equal Pay and Job-Based Employment 6. Q&A / Business Card Exchange

Jun 29, 2026

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