Notice of Participation in COSME Week 2026 / 16th Cosmetics Development Exhibition

Natural anionic surfactant upcycled from coffee by-products.

To produce 1 kilogram of coffee, 20 kilograms of CO2 are required. However, only 1% of the coffee beans are used in the production process, while 99% is discarded. Cafe Bueno has achieved zero waste by utilizing this residue as a cosmetic ingredient. KLEANSTANT is a natural anionic surfactant upcycled from coffee by-products, containing potassium palmitate, linoleic acid, polyphenols, tocopherols, and diterpene esters. In addition to its cleansing properties, foaming ability, and antioxidant effects, it also has moisturizing benefits. KLEANSTANT exhibits high foaming performance when the original pH is lowered through neutralization treatment. It shows the best performance at a pH of 5 to 6, and citric acid also contributes to the removal of residues and improvement of emulsification. However, at a pH of 4, foaming ability may decrease.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

A scrub made from upcycled coffee beans. It has a mild texture due to particle size being below 150μm. It can be used for coloring formulations.

It is said that 20 kilograms of CO2 are needed to produce 1 kilogram of coffee. However, only 1% of the coffee beans are used in production, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. KAFFIBRE is a natural scrub expected to be a substitute for microplastics. It features a particle size of less than 150μm, making it easy to incorporate into formulations.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

An extract containing melanoidin. It has UV absorption effects and suppresses the production of glycation substances. Anti-aging effects (improvement of spots and wrinkles).

To produce 1 kilogram of coffee, 20 kilograms of CO2 are required. However, only 1% of the coffee beans are used in production, while 99% is discarded. Cafe Bueno has achieved zero waste by using this residue as a cosmetic ingredient. KAFFEAGE is a powdered extract product that has powdered the water-soluble active ingredients contained in coffee residue. It contains polyphenols and melanoidins. Efficacy: UV Protection: Confirmed absorption in the UV range, suppresses the production of glycation substances caused by UV. SPF Boost: +73.9% (1.8% added) Crow's Feet Wrinkles: -12% Elasticity Improvement: +12.2% Moisturizing Effect: +16.37%

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

A lipid-soluble hyaluronic acid sodium derivative with caprylic acid introduced. It can be used in oil products for hair care, skin care, and lip care.

<About Contipro> It is a biotechnology company and a global manufacturer that has been producing active ingredients used in the pharmaceutical and cosmetic industries for nearly 30 years. We offer a range of products including sodium hyaluronate and its derivatives produced by fermentation, as well as distinctive peptides and natural polysaccharides. <Product Introduction> This is an oil-soluble sodium hyaluronate derivative with caprylic acid. It can be used in oil phases for lip products, balms, hair oils, nail care, and more. <Efficacy> - Stimulates hair growth - Improves cuticles - Increases lip volume - Improves elasticity - Reduces wrinkles: 35% - Shrinks pores: 30% - Smoothing effect - Reduces erythema: over 10% and more.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Hyaluronic Acid Na for Whitening that Maximizes the Function of Alpha-Linolenic Acid

HyWhite is a sodium hyaluronate with whitening (brightening) properties manufactured by Contipro in the Czech Republic. HyWhite is a product that has high whitening (brightening) effects, made by partially replacing low molecular weight sodium hyaluronate with alpha-linolenic acid, which has high permeability to the skin. Alpha-linolenic acid is widely known for its strong melanin production suppression effects, and in in-vitro results, it has been confirmed to have a higher suppression effect than kojic acid. On the other hand, it is also known as a component that is difficult to formulate due to its low skin permeability and instability. This product promotes the absorption of alpha-linolenic acid, which has been a problem in the past, by replacing part of the low molecular weight hyaluronate with alpha-linolenic acid, thereby improving stability and maximizing the effects of alpha-linolenic acid. *In addition to HyWhite, Contipro also manufactures sodium hyaluronate, hydrolyzed sodium hyaluronate, and other hyaluronate derivatives.

• Other additives
• Cosmetic materials and raw materials

It is a porous silica micro powder derived from bamboo. It has improved usability, sebum absorption effects, shine suppression, and deodorizing effects.

This is silica derived from bamboo originating in the forests of India. Properties: White powder Particle size: ≦15μm Silica content: ≦87% Mechanism of action: The porous particles of fine micro powder absorb excess sebum and sweat, reducing shine and drying sweat. Effectiveness: - Reduces skin oiliness and controls shine, improving makeup longevity. - Absorbs sweat and keeps the skin dry, thus reducing odor. In Vitro: Artificial sebum absorption capacity: Twice its own weight In Vivo: Antiperspirant effect: -26% (after 4 hours) Odor suppression: -40% (after 4 hours)

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Ginger root extract containing gingerol, which has whitening effects, longevity effects, stress resistance, antioxidant properties, and calming effects.

This is an oil extract made from ginger roots sourced from Madagascar, extracted with triheptanoin. LUMILYS suppresses lipofuscin and melanin, the root causes of age-related spots, through both traditional and new mechanisms of action. Old mechanism: It suppresses the production of lipofuscin and melanin through antioxidant and anti-inflammatory effects. New mechanism: By inhibiting growth factor SCF and nerve factor RGMB, it directly acts on melanocytes to fundamentally control melanin production. *RGMB is a factor secreted from nerves when they interact with melanocytes (LUMILYS acts on the nerves). Active ingredients: • Gingerol: >32%/dry weight *A component that possesses whitening effects, longevity effects, stress resistance, antioxidant effects, and calming effects (6-gingerol: >20%, 8-gingerol: >4%, 10-gingerol: >4%) Efficacy: Antioxidant: EC50: 0.25% IL8: -46% Reactive oxygen species: -46.5% Growth factor SCF: -27% Nerve factor RGMB: -12% Lipofuscin accumulation: -26% Melanin production: -46% Currently conducting In Vivo studies.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Extreme environment microorganisms, long-lasting moisture, UV protection, Langerhans cell protection, anti-pollution, anti-aging, fermentation, hair care.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water per 1 mole of Ectoin, exhibiting cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules, forming a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV radiation, and dehydration. ― About Effectiveness ― Moisturizing Persistence (In-Vivo): Lasts for 1 week. Skin Barrier Function and Protection of Langerhans Cells (In-Vivo): 100% protection. Promotion of Heat Shock Protein Production (In-Vitro), Anti-Pollution Effect (Ex-Vivo), Protection against Blue Light, UV-A, UV-B, IR-A, and Heat, Anti-Aging Effects (In-Vivo): Improvement in Skin Roughness (86% improvement), Wrinkle Depth (32% improvement), Elasticity (82% improvement), Smoothness (61% improvement), Whitening Effect (In-Vivo): Improvement in Skin Pigmentation (25% improvement).

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

We will be exhibiting at the "P-MEC Japan 2025 Pharmaceutical Ingredients and Equipment Exhibition" held at Tokyo Big Sight. During the event, we will showcase various products. We invite all relevant parties to come and visit us. 【Suppliers】 ・LAUDA

Seiko Co., Ltd. will be exhibiting at the "11th Monozukuri World Nagoya" held at Port Messe Nagoya. This exhibition features approximately 630 companies showcasing advanced technologies that contribute to shortening development and manufacturing periods, promoting DX and IT, reducing costs, and enhancing energy efficiency and automation in factories, including IT and DX products, parts, equipment, devices, and measurement products. We plan to display the actual cabinet for equipment management, "SMART BEE," so please be sure to visit us. 【Model Numbers】 ■ Vending Machine Type Tool Management Cabinet Smart Bee X, Smart Bee S, Cute Bee, Smart Bee Pro ■ Locker Shelf Type Tool and Consumables Management Cabinet T Series: T57, T100, T108 TW Series (with electronic scale): TW45, TW68, Hyper S, Hive

We will be exhibiting at "Japan DX Week Spring 2026," which will be held at Tokyo Big Sight from April 8 (Wednesday) to April 10 (Friday). At the Marble booth, we plan to showcase how AI can improve work efficiency and lead to business automation in on-site operations. Additionally, we will provide an opportunity to experience a demonstration utilizing the latest technology, AR. Furthermore, for our manufacturing industry customers, we will present proposals under the theme "Utilizing Drawings to Drive DX," promoting the digitalization of design and quality areas, and introducing packaged products and custom services aimed at enhancing productivity in the manufacturing sector.

Core systems are the foundational support for corporate management, and their importance is increasingly heightened in the DX era, where data becomes a source of competitive advantage. To respond swiftly and flexibly to the rapidly changing business environment, a transformation in the nature of systems is required. We will introduce a method to realize a highly flexible and scalable business system that promotes operational efficiency and data utilization through the combination of kintone and ASTERIA Warp, using examples and demonstrations.

The widespread adoption of generative AI is rapidly evolving from traditional "conversational AI" to "autonomous execution AI (AI agents)." The AI agents that have recently garnered attention are not limited to merely generating responses; they can incorporate an autonomous processing flow of "planning → task decomposition → execution → evaluation," serving as new partners that can substitute and expand users' business operations. In this seminar, we will clearly introduce the following topics, incorporating examples of the AI solution "AIdea Suite AGENT +plus" and the data integration tool "ASTERIA Warp": - Why "AI agents" are becoming essential for corporate competitiveness now - The mechanisms of AI agents and specific use cases - Methods for establishing business efficiency, creating new value, and gaining a competitive edge - Specific steps for implementing AI agents - Data integration and its methods, which are essential for utilizing AI *This is a re-broadcast of the seminar held on October 30, 2025 (Thursday).