◆On-Demand Webinar Distribution◆ A Ray of Hope for Challenges in LNP Research and Development

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

The transition from LNP to GMP is a costly and complicated process. Typically, this requires switching equipment, using different flow paths and mixing devices, and essentially re-developing and re-validating everything that has been painstakingly done so far. With Sunbather, the transition to GMP can be done easily thanks to its recording features, interchangeable flow paths, and easily transferable design. Sunbather uses the same mixing process and protocols as the Sunscreen and Sunshine from the same Sun series, allowing for easy transition of adjusted formulation conditions to GMP. - Up to 1.8 L/h - Integrated inline dilution - Fully interchangeable flow paths - A wide variety of mixing devices - Software compliant with 21 CFR Part 11 - Process transferable from Sunshine

• Other Physics and Chemistry Equipment

Recently, we held technical training sessions for the MilkoScan FT3 at five locations nationwide. In this training, we provided a wide range of useful information for operating the equipment, including explanations of the principles and structure of the device, how to create measurement products, daily maintenance, and how to respond to issues when they arise. Additionally, this year we introduced new methods for utilizing digital services (such as FossCalibrator and IQX) and also prepared hands-on sessions where participants could experience operating the equipment using a PC. Thank you to everyone who participated. Please feel free to contact us with any questions after the training. ------- At Foss Japan, in addition to training sessions and workshops to ensure you can use our equipment with confidence, we hold many events throughout the year. In seminars and open houses tailored to specific industries and analytical techniques, we showcase Foss's latest analytical solutions. -------

[Lecturers] EY Strategy and Consulting Co., Ltd. Infrastructure Advisory Partner Kenichiro Fukuda Strategy Partner Ken Fujiyama Infrastructure Advisory Director Takashi Matsumura [Key Lecture Content] The water supply and sewage business is facing structural challenges such as facility aging, a shortage of workforce, and a decrease in revenue due to population decline. The government is promoting the introduction of Water PPPs, regional consolidation, and the digital transformation of water supply and sewage systems, marking a significant turning point in the way these businesses are operated. This change is expanding business opportunities for private companies in various areas, including operation and maintenance, pipeline renewal, digital technology, and the utilization of smart meters and data. Additionally, as a means of expanding business domains and enhancing competitiveness, there has been an increase in capital and operational partnerships and M&A between companies, leading to industry restructuring. In this seminar, based on the latest trends in policy and the market, we will introduce business strategies for private companies to enter and expand in the water supply and sewage market, including the use of M&A and capital operational partnerships, drawing on achievements from both public and private support.

[Lecturer] Koichi Iwama, Professor, Faculty of Economics and Management, Wako University / Chairman, Resource Economics Committee, Petroleum Technology Association [Key Lecture Content] In light of the prolonged crisis in the Strait of Hormuz, what will happen to the development of shale gas and shale oil in the United States moving forward? After the midterm elections, what will be the international LNG prices under the Trump administration after winter 2027? How will Japan's business strategies related to LNG projects grow? A leading expert on the shale gas and shale oil revolutions will clearly explain the future outlook.

[Lecture Items] 1. Initiatives for Promoting Smart Cities at the Ministry of Land, Infrastructure, Transport and Tourism Ministry of Land, Infrastructure, Transport and Tourism, Urban Bureau, International and Digital Policy Division, Digital Information Utilization Promotion Office Planning Specialist Mr. Masahiro Kobayashi 1. Initiatives to Promote the Spread of Smart Cities 2. Promotion of the Development and Utilization of 3D Urban Models in Project PLATEAU 3. Q&A / Business Card Exchange 2. Smart Cities in the AI Era - Creating "Light Cities" that Continuously Unleash the Potential of Urban Areas - NTT Urban Solutions Inc., Urban Development Promotion Headquarters, Innovation Promotion Department, Deputy Director NTT Urban Development Corporation, Digital Innovation Promotion Department, Director Mr. Shinya Date 1. Changes in the Environment Surrounding Smart Cities and the Transformation of Urban Development 2. NTT's Vision for Creating "Light Cities" - Urban Development that Continues to Unleash the Potential of Cities 3. Evolution and Value Creation of Smart Cities in an AI-Driven Society 4. Considering Future Urban Models and Co-Creation Possibilities from Social Implementation Cases in Hibiya 5. Q&A / Business Card Exchange

[Speaker] Mitsui & Co., Ltd. Research Institute, Technology and Innovation Information Department Senior Project Manager, Zhao Jian [Key Lecture Content] Low-cost lithium iron phosphate (LFP) lithium-ion batteries are expanding their adoption worldwide. To prepare for future mass emissions, promoting their recycling is essential. However, due to the low material value of LFP batteries, ensuring the profitability of recycling operations has become a challenge. In pursuit of profitability, Chinese companies are seeking economies of scale and integrating battery material manufacturing, while in Europe and other regions, there is a focus on developing high-efficiency and high-purity recovery technologies such as direct recycling. This lecture will explain the current status, challenges, latest trends in technology development, and the impact on the battery supply chain regarding LFP battery recycling. [Lecture Items] 1. The necessity of LFP battery recycling 2. The current status of LFP battery recycling 3. Efforts to improve the profitability of LFP battery recycling 4. Impact on the supply chain & summary 5. Q&A / Business card exchange