Accelerating Neurodegenerative Disease Research with Proteomics Webinar | Olink Use Cases and Latest Applications

Analysis platform adopted by the world's largest human proteome study, "UK Biobank-PPP."

Olink Explore HT is a next-generation multiplex proteomics analysis platform that extracts an overwhelming amount of information from small sample volumes. It can simultaneously measure over 5,400 proteins from just 2 µL of diverse samples such as plasma, serum, and CSF, achieving 99.5% high specificity and reproducibility through its unique PEA (Proximity Extension Assay) technology. By combining an automated workflow with NGS readouts, it enables high-precision and efficient analysis, accommodating a wide range of research phases from biomarker discovery to clinical research and drug development. Furthermore, it has been adopted in The UK Biobank Pharma Proteomics Project, the largest human proteome study in the world, demonstrating its performance and reliability in large-scale research projects. In addition to the installation of the equipment in laboratories, it is also available through service providers and Olink analysis services, with our staff supporting the experimental design phase according to research objectives and analysis needs.

• Other protein analysis
• Research Antibodies
• Other Protein Research

Research on neurodegenerative diseases using PEA technology, pioneering with the latest markers and absolute quantification.

Olink Target 48 Neurodegeneration is a high-performance proteomics panel specialized in neurodegenerative disease research. It can simultaneously measure 41 types of proteins, including the latest and important central nervous system biomarkers such as Aß40, Aß42, pTau217, NfL, and GFAP, which are gaining attention in Alzheimer's and Parkinson's disease research. This panel enables the acquisition of absolute quantification (ng/mL) data, which is difficult with other technologies, allowing for data comparison between studies and institutions, as well as high reproducibility in long-term longitudinal studies. With just 1µL of plasma or cerebrospinal fluid, high-sensitivity measurements can be achieved, maximizing the use of valuable clinical samples. Furthermore, by combining analyses with Olink's cytokine panel, it comprehensively captures neurodegeneration and neuroinflammation, significantly enhancing analytical power. The standardized workflow using the Signature Q100 system contributes broadly from basic research to clinical and drug discovery research.

• Analysis and sequencing services
• Other protein analysis
• Research Antibodies

Multiplex Approach to Multifactorial Diseases: A New Era in Neurodegenerative Biomarker Research

Olink's neurobiomarker analysis is a proteomics method that allows for the highly sensitive and specific simultaneous measurement of neurodegenerative disease-related proteins from limited samples such as plasma, serum, and cerebrospinal fluid, using Proximity Extension Assay (PEA) technology. Olink Target 48 Neurodegeneration enables the absolute quantification of markers important in neurodegenerative disease research, such as Aß40, Aß42, pTau217, NfL, and GFAP, making it useful for longitudinal studies and inter-facility comparisons. Furthermore, by using Olink Explore HT and Target 96 Neurology, a broad protein profiling analysis including neuroinflammation and synaptic function becomes possible, supporting the identification of novel biomarkers and elucidation of pathological mechanisms. **Effects of Implementation** - Promotion of understanding disease mechanisms through comprehensive analysis of neuroinflammation-related proteins. - Increased efficiency in biomarker discovery and contribution to drug development research. - Ability to measure numerous proteins from a small amount of sample, allowing for effective use of valuable samples.

• Other protein analysis
• Research Antibodies
• Other Protein Research

Nitto Kohki will be exhibiting at the "Data Center EXPO" held at Makuhari Messe Hall 1 from Wednesday, October 23 to Friday, October 25. [Booth Number: A6-23] At this exhibition, we will showcase the "Compact Zero Spill Coupler," which is specifically designed for data centers, including supercomputers. We will also present the "Blind Mate Type," a fitting exclusively for server cooling piping, as a reference exhibit.

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely invite you to visit us during this busy time. 【 Exhibition Name 】 Automotive Technology Exhibition 2025 YOKOHAMA https://aee.expo-info.jsae.or.jp/ja/yokohama/ (An "online exhibition" will also be held during and around the event period) 【 Dates 】 May 21 (Wednesday) - 23 (Friday), 2024 10:00 AM - 6:00 PM *On the final day, 9:00 AM - 4:00 PM (Online exhibition: May 14 (Wednesday) - June 4 (Wednesday)) 【 Venue 】 Pacifico Yokohama (1-1-1 Minatomirai, Nishi-ku, Yokohama, Kanagawa Prefecture) Our booth number: "Concourse 505"

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will showcase a variety of products, including new ones. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to attend this event. 【 Exhibition Name 】 27th INTERPHEX Week Tokyo https://www.interphex.jp/tokyo/ja-jp.html 【 Dates 】 July 9 (Wednesday) - 11 (Friday), 2025 10:00 AM - 5:00 PM 【 Venue 】 Tokyo Big Sight (3-11-1 Ariake, Koto-ku, Tokyo 135-0063)

[Lecturer] Taku Ito, Partner, Mori Hamada & Matsumoto Foreign Law Joint Enterprise Yoshifumi Nagakubo, Senior Associate [Key Lecture Content] As we move towards a carbon-neutral society, the large-scale introduction of renewable energy sources is progressing, making the enhancement of market design that balances stable electricity supply and economic efficiency an urgent issue. In this context, the "simultaneous market," which integrates the trading of electricity (kWh) and adjustment capacity (ΔkW), is being discussed as a core component of future electricity systems, and serious considerations for its implementation are underway. In this lecture, a lawyer who has led discussions at the forefront of national system design will explain in an easy-to-understand manner the background and necessity of the simultaneous market, as well as the overall picture of its complex mechanisms, based on practical experience. Furthermore, the lecture will clearly outline the latest developments in current discussions, realistic challenges for implementation, and prospects for future electricity business in Japan, incorporating perspectives and insights as a system designer and practitioner.

[Instructor] Hirokazu Shibata, President and CEO of ZAZU Design Co., Ltd. [Key Lecture Content] As the importance of heat dissipation design increases in daily operations, it is necessary to study a range of books on thermal engineering to learn the overall picture of heat dissipation design. However, books on thermal engineering typically start with the basics of heat transfer and cover topics such as temperature boundary layers and dimensionless numbers related to heat transfer, making it quite difficult for beginners to grasp the overall picture in a short period. This seminar is aimed at engineers who will begin thermal design in the future, focusing on various heat dissipation devices as specific subjects. The goal is to understand the basics of thermal design while learning about the characteristics and usage of these heat dissipation devices. After attending this seminar, participants are expected to acquire knowledge equivalent to that gained from studying a range of thermal engineering books. [Lecture Topics] 1. Current Status and Challenges of Thermal Design 2. How "Thermal Resistance" Determines Heat Dissipation Pathways 3. Fundamental Laws Governing Heat Transfer 4. Air Cooling through Heat Transfer 5. Heat Diffusion through Thermal Conduction 6. Heat Transfer via Two-Phase Flow of Gas and Liquid 7. Q&A Session