Free invitation with pre-registration! Announcement of participation in the 28th Interphex Japan Exhibition.

Enhanced leakage prevention performance with the adoption of a new seal structure! Diaphragm valves for pharmaceuticals, bioprocesses, cosmetics, food, and semiconductor manufacturing equipment!

Starting from July 2025, we will begin accepting orders for our new product series, the "EX-Bioclean Diaphragm Valve." This product is an evolution of the existing "Bioclean Diaphragm Valve" series designed for pharmaceutical and related facilities, featuring a new sealing structure for diaphragm valves. While maximizing the characteristics of diaphragm valves that have a "structure that does not contaminate fluids" and "excellent cleanability," we have revamped the sealing structure to meet user needs and further enhance product performance. 【Features】 ■ Improved airtightness! - New sealing structure that maintains high airtightness ■ Improved maintainability! - Enhanced workability during diaphragm assembly (reduced assembly time, possible omission of tightening and alignment tasks) ■ Ensured compatibility! - Same performance in the wetted parts as conventional products - Durability and seat sealing performance equivalent to conventional products - Compatible with existing valve bodies ■ Safety performance and quality! - Can accommodate tightening in emergencies - Applies safety technology proven in domestic nuclear power plants *For more details, please refer to the catalog or feel free to contact us.

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Excellent corrosion and chemical resistance! In response to many requests, we have renewed our product!

This is a corrosion-resistant valve with a total lining of glass that excels in corrosion resistance, making it suitable for use with highly permeable chemical solutions. 【Features】 ■ Excellent corrosion and permeation resistance: It can be used with strong acids such as hydrochloric acid and concentrated nitric acid, as well as highly permeable chlorine gas. It has corrosion resistance against almost all chemicals, except for some such as alkalis. ■ Wear resistance: Compared to PFA linings, which show similar corrosion resistance, it has superior wear resistance, making it suitable for use with slurry-type chemical solutions. *For more details, please refer to the PDF document or feel free to contact us.

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• Valves and fittings
• Other water treatment

The issues caused by "dead space" in the plumbing equipment that you had given up on can be resolved immediately!

■NDV Dead Space Countermeasure Products These are products designed with a valve body structure that eliminates dead space (such as pockets and liquid accumulation) and is compact. Representative examples include sampling valves for collecting fluid samples, three-way valves that allow for fluid switching and mixing with a single body, and tank bottom valves that achieve high stirring efficiency and complete discharge without residue. 【Do you have any of these concerns?】 ☑ The narrow and small drain area at the bottom of the tank is difficult to stir, creating dead space... ☑ During liquid discharge or when closing the valve, liquid gets trapped in the gaps of the valve mechanism... ☑ Large dead legs in piping increase the required piping space... 【Features】 ● Sampling Valve Type P: Enables fluid sampling without dead space! ● Three-Way Valve Type K: Allows for switching and mixing of flow paths without dead space! ● Tank Bottom Valve Type T: A dedicated valve for tank bottoms that excels in stirring efficiency without dead space! ● Self-Drain Type F: A valve that further enhances the effect of preventing liquid accumulation! ■ This product will be exhibited at the "27th Interphex Japan." *For more details, please refer to the catalog or feel free to contact us.

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No dead space (in pockets or liquid traps), fluid sampling is OK. Can be used widely!!

**Features** - Fluid sampling can be done without dead space (such as in pockets or liquid pools). - It can be directly mounted in the piping, is compact, and has a structure that prevents fluid retention in the valve. - In addition to sample collection, it can be widely used for branching, merging (mixing), introducing cleaning water or sterilizing steam, and discharging. **Specifications (Excerpt)** - Main body material: SUS316L - Applicable nominal diameter (DN): Standard combinations of main pipe and valve: 15 to 50 (other ranges available as options) - Operation method: Both manual and pneumatic operation methods are applicable. *For more details, please refer to the PDF document or feel free to contact us.*

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Easy with 90-degree operation! Prevents over-tightening and damage! "I'm worried if it's tightened securely..." We solve this kind of problem.

The "BQL400NB model" is a rapid opening and closing type handle diaphragm valve from BioClean. While the standard handle type requires about 5 rotations for operation (in the case of DN50), the rapid opening and closing handle allows for a very simple operation of just "opening and closing by 90 degrees." The valve's open and closed status can be clearly identified from a distance based on the handle position. Additionally, it has achieved a lighter and more compact design compared to conventional products. We invite you to try the easy operation and stable sealing performance of the 90-degree rotating lever handle. 【We solve these problems!】 ■ Excessive opening and closing torque → Reduction is possible, greatly contributing to labor savings. ■ Want to check the opening and closing status from a distance → The valve's open and closed status can be clearly seen from a distance based on the handle position. ■ Damage caused by over-tightening the valve → Only the minimum necessary operation is required. This prevents damage and extends the lifespan. *For more details, please refer to the PDF materials or feel free to contact us. (The English and Chinese versions of the catalog can be downloaded from the catalog page of the special website below.)

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Many delivery achievements for pharmaceutical and food plants, as well as high-purity chemical solutions! It can completely block corrosive fluids.

At Nippon Diaphragm Valve, we handle "clamp-connected corrosion-resistant valves" with a body made of fluororesin (ETFE) lining. These valves are suitable for countermeasures against corrosive fluids in sanitary piping, gap corrosion due to chloride ions, and metal ion elution. With the diaphragm valve's features of "air tightness" + "corrosion resistance," they can completely shut off corrosive fluids. We have many achievements not only in pharmaceutical and food plants but also in high-purity chemical lines. 【Features】 ■ Body material: SUS316L ■ Lining material: ETFE ■ Connection method: Clamp joint (ISO2852) ■ Applicable nominal diameter: 25A to 65A (1S to 2.5S) *For more details, please refer to the PDF materials or feel free to contact us. (The English and Chinese versions of the catalog can be downloaded from the catalog page of the special website below.)

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An evolved version of the bio-clean diaphragm valve. The structure eliminates liquid pooling by positioning the valve shaft horizontally. A solution for dead space!

The self-draining type is a valve body that further enhances the liquid retention prevention effect of the Bio Clean diaphragm valve series. When this valve is installed on horizontal piping, it is designed to eliminate liquid retention by positioning the valve shaft horizontally. 【Specifications (excerpt)】 ■ Stainless steel body (Applicable nominal diameter (DN): 8 to 100) ■ Lined body (Applicable nominal diameter (DN): 15 to 50) ■ The surface finish classification of the body and diaphragm specifications follow standard specifications. ■ Various drive components for manual operation valves and pneumatic ON-OFF valves can be used interchangeably. *For more details, please refer to the PDF materials or feel free to contact us. (The English and Chinese versions of the catalog can be downloaded from the catalog page of the special website below.)

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No short pipe section and minimal dead leg! A compact design sample collection valve.

The "Bio-Clean Diaphragm Valve" is a dedicated valve for sample collection. Since it does not use a cheese fitting, there is no short pipe section, resulting in a smaller dead leg. Additionally, its compact design and lightweight construction help reduce the load on the piping. It can be widely used for introducing and discharging split flow, merging (mixing liquids), cleaning water, and sterilizing steam. 【Features】 ■ Does not use a cheese fitting ■ No short pipe section, resulting in a smaller dead leg ■ Compact installation due to the integrated structure of the main pipe and body ■ Average weight reduction of 23% compared to conventional products ■ Reduced load on piping due to lightweight design *For more details, please refer to the documentation. Feel free to contact us with any inquiries.

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【For pharmaceutical and food plants!】A butterfly valve with minimal powder and particle adhesion and excellent cleanability.

The "Sanitary Butterfly Valve for Powder and Granule Discharge" has numerous achievements in the discharge of powders and granules in pharmaceutical and food plants' containers. The main components are made of stainless steel, and the inner surface is finished with #400 buff polishing, which minimizes the adhesion of powders and granules and provides excellent cleanability. 【Features】 ■ Minimal adhesion of powders and granules, with excellent cleanability ■ Easy installation and removal for containers and piping ■ Adopts a clamp method for quick assembly and disassembly, making cleaning easy *For more details, please refer to the catalog or feel free to contact us.

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Diverting, merging, and the introduction and discharge of cleaning water and sterilizing steam are "applicable." The internal structure of the valve has no dead space, making it ideal for preventing liquid accumulation.

**Features** - It can be directly installed in the piping, is compact, and has a structure that prevents fluid residue in the valve. - It can be widely used for applications such as branching, merging (mixing liquids), introducing cleaning water, and discharging sterilization steam. **Specifications (Excerpt)** - Main body material: SUS316L - Applicable nominal diameter (DN): Standard combination of main pipe and valve: 15 to 50 (other ranges available as options) - Operation method: Both manual and pneumatic operation methods are applicable. *For more details, please refer to the catalog (P.20) or feel free to contact us. (An English version is available upon request!)*

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Tanks from approximately 10L to 10,000L are acceptable! The opening and closing are done solely by the diaphragm, allowing for smooth discharge of the tank contents with almost no residue left.

【Features】 ● The structure is directly welded to the bottom of the tank, resulting in excellent stirring efficiency. ● There are no contact parts such as gland packing, stem, seat, or gasket; the opening and closing are done solely by the diaphragm, allowing for smooth discharge of the tank contents with minimal residue. Contamination caused by valve components is extremely low, and cleaning and sterilization can be easily and reliably performed. ● The applicable nominal diameters range from DN15 to 100 (4S), making it suitable for use with small containers of about 10 liters to medium tanks of about 10,000 liters. 【Specifications (Excerpt)】 ● Main body material: SUS316L ● Applicable nominal diameter (DN): 15 to 100 ● Operation method: Manual operation and pneumatic operation methods are both applicable. *For more details, please refer to the PDF materials or feel free to contact us. (The English and Chinese versions of the catalog can be downloaded from the catalog page of the special website below.)

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It is possible to manufacture valve bodies tailored to specific applications and specifications! "Bioclean diaphragm valves that are optimal for pharmaceutical bioprocesses and more."

This product is a valve suitable for manufacturing equipment in pharmaceuticals, bioprocesses, cosmetics, food, and semiconductors. The diaphragm completely isolates the fluid from the drive mechanism, providing a highly airtight structure. It has a packless design that eliminates the gland packing area, which is often associated with a high risk of leakage in general valves, thus excelling in maintaining airtightness and preventing bacterial contamination. 【Features】 ■ Excellent airtightness ■ Structure that does not contaminate the fluid ■ Superior cleanability ■ Excellent maintainability ■ Customizable valve body to match applications and specifications *For more details, please refer to the sanitary valve catalog (pages 8-16) or feel free to contact us. (English and Chinese versions are available upon request!)

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Prevents the generation of foreign substances due to coating peeling! Air-operated ON-OFF valve made of stainless steel with excellent corrosion resistance. Compact and buff-polished for excellent cleanability.

This product is an ideal valve for manufacturing equipment in pharmaceuticals, bioprocesses, cosmetics, food, and semiconductors. The air-operated ON-OFF valve is available in the stainless steel drive model 'BPO1400N type 05S to 16S'. Since painting is not required, it prevents the occurrence of foreign substances due to peeling of the coating, and a retaining ring method is used to secure the bonnet and cylinder. With minimal unevenness and compact design, along with buff polishing, it offers excellent cleanability. 【Features】 ■ All stainless steel construction with excellent corrosion resistance ■ Exterior shape with superior cleanability ■ Significant improvement in smooth operation and durability *For more details, please refer to the catalog (P15-16) or feel free to contact us. (English and Chinese versions are available upon request!)

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Rainproof equivalent to IP67! It has been reborn with an indicator that excels in visibility!

We would like to introduce our diaphragm valve limit switch box, the 'MDNB Series', specifically designed for air-operated drive units. The indicator of the conventional model has been changed from a rubber cap to a bright red, dedicated resin indicator, improving visibility. This is a compact product with a direct mount type that incorporates a micro switch. 【Features】 ■ Direct mount type with built-in micro switch ■ Changed the indicator from a rubber cap to a bright red, dedicated resin indicator ■ Improved visibility due to the change in cap shape *For more details, please refer to the PDF document or feel free to contact us.

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Introduction of lining products that prevent deterioration from corrosion and chemicals!

Introducing the "Lining Type Diaphragm Valve" with excellent resistance to corrosion and chemicals. It is utilized in a wide range of fields such as chemicals, environmental and water treatment, pharmaceuticals, and semiconductors. It can be applied to countermeasure against corrosive fluids, gap corrosion, and metal ion elution. 【Product Lineup (Example)】 "Model 430": Hard natural rubber lining on a base material of FC200 or FCD-S "Model 459": PFA lining on a base material of FCD-S or SCS13 "Model 460": ETFE lining on a base material of FCD-S "Model 450": Polyethylene lining on a base material of FC200 "Model 480": Porcelain lining on a base material of FCD-S *Sanitary specification diaphragm valves are also available. *For more details, please refer to the catalog or feel free to contact us.

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Exhibits outstanding performance for food resistance and chemical resistance applications! Achieves stable sealing through a uniquely developed shaft sealing mechanism!

The "PFA Lined Butterfly Valve" is a highly reliable corrosion-resistant butterfly valve that is fully lined with PFA. All components that come into contact with the fluid are made of PFA, providing excellent corrosion resistance to most chemicals. The gland mechanism, which has self-sealing and wedging effects, offers high shaft sealing performance against thermal cycles and frequent opening and closing. Additionally, the inclusion of V-packing and coil springs enhances the reliability of the shaft sealing performance against external leakage. 【Features】 ■ Excellent corrosion and chemical resistance ■ High shaft sealing performance ■ Durable casing ■ Resistance to permeation and non-stick properties *For more details, please download the PDF or feel free to contact us.

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We would like to express our congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will introduce a number of products, including new ones. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to attend this event. 【 Exhibition Name 】 31st Measurement and Measurement Exhibition INTERMEASURE 2024 Official Website: https://intermeasure.org/itms2024/ 【 Dates 】 From __ (Wednesday) to __ (Friday), 202_ 【 Venue 】 Tokyo Big Sight (Tokyo International Conference Center) East Hall (Booth Number: ___) 【 Exhibited Products 】 - Air Leak Tester - Hydrogen Leak Detector - Pin Hole (Reference Test Piece) and more. For more details, please refer to the "Related Materials" (PDF file) below.

Nitto Kohki will exhibit at the "H₂ & FC EXPO Spring International Hydrogen and Fuel Cell Exhibition" held at Tokyo Big Sight, West Exhibition Hall 2, from February 28 (Wednesday) to March 1 (Friday), 2024. [Booth Number: W14-63] The quick fluid coupling "Coupler" is a product that allows for the rapid connection and disconnection of piping for various fluids such as air, water, oil, and chemical solutions. At this exhibition, we will primarily showcase the high-pressure hydrogen filling quick fluid coupling "HHV Coupler."

☆☆☆ Urgent Visit to Japan & Emergency Event Announcement ☆☆☆ Dr. Yuval Levy, CEO of ISCFDC and developer of EPPIC, who has been involved in CFD research at NASA Ames Research Center for about five years, is coming to Japan! He will demonstrate and explain advanced CFD technologies, application cases, and the latest features of EPPIC himself. □ Date and Time □ July 31, 2026 (Friday) 13:00-18:00 (Registration starts at 12:30) <Part 1: Post-Processor Session> 13:00-16:40 <Part 2: Pre-Processor Session> 16:50-17:50 <Networking Event> 18:10-19:40 □ For more details □ Visit the Hulinks page https://www.hulinks.co.jp/seminar/eppic/

[Viewer Benefits Available] Explaining Tips for LC in a Short Seminar Do you have concerns such as "I'm unsure about column selection," "I'm struggling to optimize analysis conditions," or "I have challenges analyzing compounds with weak retention" in LC analysis? Waters will hold a seminar titled "Must-Listen! Advanced LC Application Seminar" where you can learn practical LC analysis know-how in just 30 minutes. In this seminar, we will cover useful topics in a total of six sessions, including tips for choosing detectors, how to utilize reverse phase columns, scaling up to preparative LC, approaches for analyzing hydrophilic and highly polar compounds, case studies of low-adsorption HPLC, and improving purity through solid-phase extraction. Each session is scheduled to start at 15:00. Event Themes: • October 6 (Tuesday) - Session 1: Tips for Choosing Detectors • October 13 (Tuesday) - Session 2: Tips for Choosing Columns • October 21 (Wednesday) - Session 3: Tips for Preparative LC • October 27 (Tuesday) - Session 4: Approaches for Analyzing Hydrophilic and Highly Polar Compounds • November 5 (Tuesday) - Session 5: Case Studies of Low-Adsorption HPLC • November 10 (Tuesday) - Session 6: Tips for Solid-Phase Extraction

In liquid biopsy research, we will introduce a technical evaluation of proteome analysis to obtain reliable data from trace plasma, as well as case studies on data quality verification using the Contamination Index and Simple Western.