Report on the 10th COSME Tech 2020 Cosmetics Development Exhibition

Ultimate moisturizing produced by Halomonas sp. with protection (UV, BL, IRA, viruses), anti-inflammatory, and femcare ingredient Ectoin Natural.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water for every 1 mole of ectoin, giving it cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules and forms a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV exposure, and dehydration. ― About Effectiveness ― In Vivo Vaginal care effects: Reduction of vaginal atrophy symptoms, vaginal moisturization (50% improvement in dryness), improvement of vaginal heat and itching. Moisturizing persistence (lasting for 1 week), barrier recovery, erythema suppression, protection of Langerhans cells (100% protection). Anti-aging effects: Improvement in skin roughness (86% improvement), wrinkle depth (32% improvement), elasticity (82% improvement), smoothness (61% improvement), whitening effect (25% improvement). In Vitro: Promotion of heat shock protein production, anti-pollution effects (Ex-Vivo), protection against blue light, UV-A, UV-B, and IR-A.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Extreme environment microorganisms, long-lasting moisture, UV protection, Langerhans cell protection, anti-pollution, anti-aging, fermentation, hair care.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water per 1 mole of Ectoin, exhibiting cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules, forming a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV radiation, and dehydration. ― About Effectiveness ― Moisturizing Persistence (In-Vivo): Lasts for 1 week. Skin Barrier Function and Protection of Langerhans Cells (In-Vivo): 100% protection. Promotion of Heat Shock Protein Production (In-Vitro), Anti-Pollution Effect (Ex-Vivo), Protection against Blue Light, UV-A, UV-B, IR-A, and Heat, Anti-Aging Effects (In-Vivo): Improvement in Skin Roughness (86% improvement), Wrinkle Depth (32% improvement), Elasticity (82% improvement), Smoothness (61% improvement), Whitening Effect (In-Vivo): Improvement in Skin Pigmentation (25% improvement).

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Achieved 100% purity of 2αGG, the most active isomer of the miraculous resurrection plant, through our unique manufacturing technology. High moisturizing, wound healing, and cell revitalization functions.

Glycoin natural is a product composed of 100% unique structural isomers manufactured using patented biotechnology by Bitop AG in Germany. These structural isomers are found only in the miraculous resurrection plant Myrothamnus flabellifolia and blue-green algae (spirulina), which are known as the miracle plants of the desert that can revive green with just a small amount of water even after being dried for 50 years. Glycoin natural activates the rejuvenating power of tired skin, stressed skin, and aging skin. <Efficacy> Stimulates cell regeneration, growth factors, and ATP synthesis Activates antioxidant enzymes (SOD1, SOD2, CAT) Immediate moisturizing effect improved by 49% (after one application) Skin elasticity improved by 93% Skin smoothness improved by 61% Skin thickness increased by 9.9% Reduces sunburn and skin redness Tissue repair and wound healing effects maintained for 48 hours

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Achieves excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect"! Low molecular weight hyaluronic acid oligosaccharides with excellent permeability.

OligoHyaferre is a hydrolyzed sodium hyaluronate manufactured by a company in the Czech Republic, known for its excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect." In vitro studies have confirmed its effects of MMP inhibition, TNF-α inhibition, promotion of angiogenesis, and gene expression of HAS2. These effects lead to favorable results in in vivo "anti-wrinkle tests" and "skin barrier function recovery tests."

• Other additives
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

Zaltrius Japan will be exhibiting at the 98th Annual Meeting of the Japanese Society for Tissue Culture. ◼ Date: August 27 (Thursday) - 28 (Friday), 2026 ◼ Location: 2-8-35 Tai-machi, Nagaoka City, Niigata Prefecture, Hotel New Otani Nagaoka, Venue for the 98th Annual Meeting of the Japanese Society for Tissue Culture ◼ Booth: No. 11 ◼ Exhibited Products: Polyplus High-Efficiency Transfection Reagents NexaGel 3D Cell Culture Matrix Research Growth Factors and Cytokines Basic Cell Culture Media and Reagents Picus 2 Electronic Pipette We have a selection of products recommended for those considering improving research reproducibility and establishing 3D culture environments. Please come and see the actual products and applications at the venue. We look forward to your visit!

We are pleased to announce a co-hosted seminar with Live Consulting Co., Ltd. "Practical Seminar on Microsoft Copilot for Executives and Managers in the Manufacturing Industry" "The new AI tools are no longer needed." This seminar will allow you to experience Microsoft Copilot, which can be used directly within your usual Word, Excel, and Teams, through a demonstration of the actual operation screen. The answers are already within your existing Microsoft 365. You can use AI directly in Word, Excel, and Teams without the need for additional tool selection or new investments, all within the security framework of M365. We will explain the basics to practical applications of Copilot in 90 minutes, specifically for executives and managers in the manufacturing industry. We sincerely look forward to your participation. [Recommended for the following individuals] - Executives and managers in the manufacturing industry who have not yet mastered generative AI/Copilot - Those considering AI implementation but are stalled due to tool selection, security, or promotion systems - Individuals who prefer to see the "actual screen" rather than just "reading" about it - Those who are unable to use ChatGPT in their company due to security concerns.

We will hold a webinar focused on analytical challenges in the research, development, and quality control of biopharmaceuticals, particularly antibody-drug conjugates (ADCs). We are pleased to invite Professor Yuji Ito from Kagoshima University, who will give a lecture on the latest analytical strategies and practical insights in biopharmaceutical research, including ADCs. Target Audience: - Researchers, developers, and CMC personnel from pharmaceutical companies, CDMOs, and CROs - Those considering advanced analytical methods for ADCs and antibody drugs - Individuals facing challenges in improving separation performance, reproducibility, or analytical efficiency - Those considering the implementation of MAM and workflow development Lecture 1 [Special Lecture]: Next-Generation Drug Discovery Using DDS with Tissue-Translocating Antibodies - AccumBody Platform and Antibody Conjugate Technology - Professor Yuji Ito, Graduate School of Science and Engineering, Kagoshima University Lecture 2: Latest LC Column Technology to Solve Challenges in ADC and Antibody Analysis Lecture 3: MAM Practice - An Integrated Workflow from Research and Development to Quality Evaluation * This webinar is a restructured version of the content from the on-site seminar held in July 2026.

Fujikogyo Co., Ltd. will exhibit at the "5th Smart Factory EXPO Autumn" held at Makuhari Messe from September 9 (Wednesday) to September 11 (Friday), 2026. On the day, we will showcase the latest FA and robotics products that achieve automation, efficiency, and labor-saving in the field. [Main Exhibited Products] ◇ Collaborative Robot Palletizing System (Elite Robot Co.) A compact design that is mobile and integrated. It enables seamless loading and easy operation via a tablet. ◇ Autonomous Mobile Robot for Pallet Transport (FEXA Co.) A small and agile AMR. It supports fully automated transportation through shutter and elevator coordination and the use of load sensors. ◇ Automatic Sealing Machine for Packing Tape (EXTEND Co.) Compliant with decarbonization and environmental considerations. It can be used with only power, without the need for air, allowing for use without constraints of location or utilities. We will propose solutions that help solve your challenges. Please visit our booth (Hall 2 / A13-36). *Advance registration (free) is required for attendance.

The organization will hold a seminar titled "EMC Performance of In-Vehicle Devices as Considered by Automobile Manufacturers" on September 16, 2026 (Wednesday), featuring lecturers from Toyota Motor Corporation, Hino Motors, Ltd., and Daihatsu Motor Co., Ltd. In addition to presentations from the three companies, a leading expert on in-vehicle device EMC from our organization will introduce the latest topics. Furthermore, after the seminar, a technical exchange meeting will be held, allowing participants, lecturers, and our organization's technical staff to exchange information. In recent years, the acceleration of autonomous driving, connectivity, and electrification technologies has been aimed at achieving carbon neutrality and evolving mobility. Within this context, it is anticipated that the demands for EMC in electric vehicles (xEV) and fuel cell vehicles (FCV), particularly regarding the electrification of powertrains and EV components, will be stronger than ever. In this seminar, we will invite EMC experts from automobile manufacturers to explain the latest trends in standards regarding the "EMC performance required for in-vehicle devices" to suppliers. We encourage you to take advantage of this opportunity.