Report on the 10th COSME Tech 2020 Cosmetics Development Exhibition

Ultimate moisturizing produced by Halomonas sp. with protection (UV, BL, IRA, viruses), anti-inflammatory, and femcare ingredient Ectoin Natural.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water for every 1 mole of ectoin, giving it cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules and forms a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV exposure, and dehydration. ― About Effectiveness ― In Vivo Vaginal care effects: Reduction of vaginal atrophy symptoms, vaginal moisturization (50% improvement in dryness), improvement of vaginal heat and itching. Moisturizing persistence (lasting for 1 week), barrier recovery, erythema suppression, protection of Langerhans cells (100% protection). Anti-aging effects: Improvement in skin roughness (86% improvement), wrinkle depth (32% improvement), elasticity (82% improvement), smoothness (61% improvement), whitening effect (25% improvement). In Vitro: Promotion of heat shock protein production, anti-pollution effects (Ex-Vivo), protection against blue light, UV-A, UV-B, and IR-A.

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Extreme environment microorganisms, long-lasting moisture, UV protection, Langerhans cell protection, anti-pollution, anti-aging, fermentation, hair care.

<Ectoin Natural Features> Ectoin is a type of cyclic amino acid produced by extremophilic microorganisms (Halomonas) that inhabit salt lakes and deserts. It has 4 moles of bound water per 1 mole of Ectoin, exhibiting cosmotropic properties. This characteristic contributes to the stabilization of interactions between water molecules, forming a hydrocomplex. This hydrocomplex helps stabilize biological structures (such as cells, proteins, enzymes, and nucleic acids) against environmental stresses like temperature changes, high salt concentrations, strong UV radiation, and dehydration. ― About Effectiveness ― Moisturizing Persistence (In-Vivo): Lasts for 1 week. Skin Barrier Function and Protection of Langerhans Cells (In-Vivo): 100% protection. Promotion of Heat Shock Protein Production (In-Vitro), Anti-Pollution Effect (Ex-Vivo), Protection against Blue Light, UV-A, UV-B, IR-A, and Heat, Anti-Aging Effects (In-Vivo): Improvement in Skin Roughness (86% improvement), Wrinkle Depth (32% improvement), Elasticity (82% improvement), Smoothness (61% improvement), Whitening Effect (In-Vivo): Improvement in Skin Pigmentation (25% improvement).

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

Achieved 100% purity of 2αGG, the most active isomer of the miraculous resurrection plant, through our unique manufacturing technology. High moisturizing, wound healing, and cell revitalization functions.

Glycoin natural is a product composed of 100% unique structural isomers manufactured using patented biotechnology by Bitop AG in Germany. These structural isomers are found only in the miraculous resurrection plant Myrothamnus flabellifolia and blue-green algae (spirulina), which are known as the miracle plants of the desert that can revive green with just a small amount of water even after being dried for 50 years. Glycoin natural activates the rejuvenating power of tired skin, stressed skin, and aging skin. <Efficacy> Stimulates cell regeneration, growth factors, and ATP synthesis Activates antioxidant enzymes (SOD1, SOD2, CAT) Immediate moisturizing effect improved by 49% (after one application) Skin elasticity improved by 93% Skin smoothness improved by 61% Skin thickness increased by 9.9% Reduces sunburn and skin redness Tissue repair and wound healing effects maintained for 48 hours

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

New hyaluronic acid crosspolymer, refreshing and moist feeling, anti-wrinkle, pore care, pore tightening, moisturizing effect.

Cross Linked HA is a hyaluronic acid cross-polymer made using Contipro's patented manufacturing method. The patented manufacturing technology creates a soft and fine gel, providing a unique sensation that is not found in conventional high molecular weight sodium hyaluronate. <About the Sensation> Immediately after application, it retains the pleasant texture of the chewy sodium hyaluronate, while the fine gel quickly penetrates the skin's grooves (such as wrinkles and pores), resulting in a moist yet refreshing sensation. <About Effectiveness> - Moisturizing effect (62% improvement) - Anti-wrinkle effect (46% reduction in wrinkles) - Sustained release effect of active ingredients (51% increase in the activity of Vitamin B3)

• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients
• Other medical supplies and cosmetic manufacturing materials

We are introducing Contipro's hyaluronic acid derivatives, such as sodium hyaluronate and hydrolyzed sodium hyaluronate, which have unique efficacy.

Contipro is a biotechnology company located in the Czech Republic. It is a global manufacturer that produces and sells various active ingredients, primarily sodium hyaluronate, in the pharmaceutical and cosmetic fields, supplying to over 60 countries for approximately 30 years. The listed products are categorized into three groups: sodium hyaluronate, natural polysaccharides, and peptides. <Sodium Hyaluronate> We offer grades with a molecular weight distribution ranging from 2.3 million Da to 10,000 Da, and we have confirmed differences in efficacy due to varying skin permeability based on molecular weight through Vivo and Vitro data. Additionally, we also have hydrolyzed sodium hyaluronate as a grade with excellent skin permeability. <Derivatives> We have confirmed through Vivo and Vitro data that sodium hyaluronate possesses not only its inherent properties of moisturizing, barrier function, anti-wrinkle, and calming effects but also efficacy in whitening, sebum secretion regulation, sebum suppression, and improvement of skin texture. *For more details, please download the PDF or feel free to contact us.

• Pharmaceutical materials and carriers
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

Hyaluronic Acid Na for Whitening that Maximizes the Function of Alpha-Linolenic Acid

HyWhite is a sodium hyaluronate with whitening (brightening) properties manufactured by Contipro in the Czech Republic. HyWhite is a product that has high whitening (brightening) effects, made by partially replacing low molecular weight sodium hyaluronate with alpha-linolenic acid, which has high permeability to the skin. Alpha-linolenic acid is widely known for its strong melanin production suppression effects, and in in-vitro results, it has been confirmed to have a higher suppression effect than kojic acid. On the other hand, it is also known as a component that is difficult to formulate due to its low skin permeability and instability. This product promotes the absorption of alpha-linolenic acid, which has been a problem in the past, by replacing part of the low molecular weight hyaluronate with alpha-linolenic acid, thereby improving stability and maximizing the effects of alpha-linolenic acid. *In addition to HyWhite, Contipro also manufactures sodium hyaluronate, hydrolyzed sodium hyaluronate, and other hyaluronate derivatives.

• Other additives
• Cosmetic materials and raw materials

Achieves excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect"! Low molecular weight hyaluronic acid oligosaccharides with excellent permeability.

OligoHyaferre is a hydrolyzed sodium hyaluronate manufactured by a company in the Czech Republic, known for its excellent "anti-wrinkle effect," "moisture retention effect," and "skin barrier function recovery effect." In vitro studies have confirmed its effects of MMP inhibition, TNF-α inhibition, promotion of angiogenesis, and gene expression of HAS2. These effects lead to favorable results in in vivo "anti-wrinkle tests" and "skin barrier function recovery tests."

• Other additives
• Cosmetic materials and raw materials
• Other pharmaceutical intermediates and cosmetic ingredients

[Lecture Topics] 1. Trends in Policies for Decarbonization of Housing and Buildings Tetsuya Hirayama, Deputy Director, Housing Bureau, Ministry of Land, Infrastructure, Transport and Tourism (in charge of architectural planning) 2. Construction Circular Economy - Expanding Horizontal Recycling for Achieving Sustainable Construction Takahiro Moritomi, Analyst, Social Infrastructure Team, Next Generation Infrastructure and Services Office, Industry Research Department, Mizuho Bank, Ltd. 3. Beyond "Scrap and Build" Aiming for the Realization of "Circular Design Build®" Shoichi Fukui, Senior Chief Expert, Sustainability Promotion Department, Management Planning Office, Takenaka Corporation

[Instructor] Attorney Kurato Suzuki, Irokawa Law Office [Key Lecture Content] Due to the amendments to the Comprehensive Promotion Law for Labor Policies, starting from October 1, 2026, employers will be required to take necessary measures in employment management regarding customer harassment (Kasu Hara) and sexual harassment against job seekers (Job Hunting Sexual Harassment). In line with this, companies will need to prepare for practical implementation before the enforcement date, based on the guidelines published by the Ministry of Health, Labour and Welfare. This includes developing internal regulations, establishing consultation and response systems, raising awareness within the company, and determining judgment and response methods on-site. This seminar will organize the setting of job hunting rules related to job hunting sexual harassment, internal awareness, and key points for regulatory development. It will also explain the distinction between legitimate complaints and customer harassment, judgment, documentation, and response on-site, the establishment of a company-wide system, regulatory development considering dispute risks, and points that are easily overlooked. The Human Resources, Labor, Legal, and Compliance departments will systematically organize the response matters that need to be confirmed in preparation for the enforcement on October 1, 2026, from the perspectives of guideline compliance and on-site operations. [Lecture Items] 1. Job Hunting Sexual Harassment 2. Customer Harassment 3. Q&A

[Speaker] Mr. Itsuki Wakayama, Project General Manager, Technology Promotion Unit, Low Carbon Solutions Division, INPEX Corporation [Key Lecture Content] The greatest advantage of synthetic methane production through CO2 methanation technology is that it enables decarbonization without significant additions or modifications to all existing natural gas and city gas infrastructure. At INPEX, after two NEDO commissioned projects, we have been conducting the development of practical application technology with a capacity of 400 Nm3-CO2/h, one of the largest in the world, as a subsidized project by NEDO since the fiscal year 2021. By the fiscal year 2025, we aim to achieve the injection of synthetic methane produced during the demonstration operation of the test facility. This presentation will provide detailed information on the results of the NEDO project for the fiscal year 2025, including the current status of the latest test facilities. [Presentation Items] 1. INPEX's efforts towards net zero by 2050 2. Policy trends related to CO2 methanation 3. Challenges of CO2 methanation 4. Results of the NEDO practical application technology development project with a capacity of 400 Nm3-CO2/h for the fiscal year 2025 5. Future commercialization prospects and challenges 6. Q&A / Business card exchange

[Speaker] Mr. Satoru Shimizu, President and CEO of Okunote Inc. [Key Lecture Content] Generative AI is not a "magic wand," but a "mirror" that reflects the questions of the user. In this lecture, based on my book "The 'Super' Planning Techniques Practiced by Competition Disruptors: Seven Creative Steps to Lead Winning Strategies with the 'Art of Questioning'," I will explain how to overcome the challenges of proposals being rejected, not moving forward within the company, and not being executed on-site through interactions with AI. I will introduce the entire process of planning, linking it with AI utilization, from question design to hypothesis destruction, structuring materials from the decision-maker's perspective, forming internal consensus, managing execution, and turning reflections into assets. In the latter part of the workshop (exclusive to on-site participants), you will actually formulate questions and refine your dialogue with AI, taking home usable "art of questioning" techniques for tomorrow. [Lecture Items] 1. Orientation: AI is a "mirror," not a "magic wand." 2. Enhancing the precision of planning through "question design" and "hypothesis destruction." 3. Structuring materials from the decision-maker's perspective to create "acceptable" proposals. 4. Forming consensus that transcends internal barriers. 5. Mechanisms that prevent execution from stopping and turning experiences into assets through reflection. 6. Habitualizing AI as a "partner" and the roles humans will take on in the AI era.

【Exhibition Overview】 A collection of products related to data centers, which are at the core of AI infrastructure, gathered in one place.