[Announcement of Webinar] Agilent Pharma / Biopharma Virtual Summit 2021

Agilent dissolution tester online UV system

The Cary 60 spectrophotometer, when combined with a pump in an online UV system, along with the sampling station 850-DS, allows for filter filtration and simultaneous sampling into test tubes or HPLC vials after filtration. **Evaluation Method for Drugs in Dissolution Testing Using Fiber Optics** Using fiber optics enables direct quantification of drugs within the vessel without the need for sampling. For example, when using fiber optics in dissolution testing for the evaluation of crystallization suppression of solid dispersions aimed at improving solubility, detailed dissolution profiles can be obtained through measurements at short intervals, as no sampling is required.

• UV/visible spectrophotometer

JP17 Bureau Reference Information: Mechanical Calibration Correspondence for Dissolution Test Apparatus

The 280-DS MQS measures the parameters of mechanical calibration of dissolution testers with high precision. Measurement is done hands-free thanks to sensor technology, taking only about 30 minutes per unit. It complies with 21 CFR Part 11. ★ Mechanical calibration has been included as reference information in the 17th edition revision. "To aim for reduced variability in test results through mechanical calibration, it is recommended to apply this reference information." (From the 17th Japanese Pharmacopoeia revision "Standard Methods for Mechanical Calibration of Dissolution Testers")

• Dissolution Tester

Corresponds to the Japanese Pharmacopoeia, USP, and EP3. The design minimizes mechanical variation factors of the device using vessels that reduce the deviation of the container's centering.

The dissolution tester 708-DS features one-touch centering with the TruAlign vessel, and its design minimizes the risk of misalignment after installation, reducing the risk of failure during mechanical calibration. It supports Japanese language, has a two-piece paddle, and significantly improves basic operability with an expanded space between the drive unit and the vessel plate. It accommodates a wide range of dosage forms for dissolution testing, including tablets, capsules, rotating cylinders, and the paddle-over-disk method.

• Dissolution Tester

It automatically performs sample suction, filtration, and collection from the dissolution tester.

■Efficiency Automation enables easy and quick sampling. It eliminates the labor involved in dissolution testing and prevents variations in sampling volume and position that would be difficult to manage manually. All functions, including the pump, filter (optional), and sampler, are integrated into a device just 39 cm wide. One filter plate used for sample filtration contains the equivalent of eight 0.45 μm filters. ■Flexibility In addition to the standard pump function, you can select filter functions according to your needs. Sampling can accommodate test tubes, HPLC vials, and well plates. ■Accuracy The rotary piston syringe pump ensures precise sampling of the specified amount at designated sampling points. Uniformity The color touch panel of the 850-DS allows for input of the dissolution test program. ■Test Results Test data can be printed using the built-in printer.

• Dissolution Tester

Management of test data, data integrity, dissolution testing software!

Since 2015, guidance on data integrity (DI) has been issued by the MHRA (UK Medicines and Healthcare products Regulatory Agency), WHO, FDA, and PIC/S, and its importance has been increasing in recent years. DI is defined as "the completeness, consistency, and accuracy of data. Data that is complete, consistent, and accurate is recorded with attributes of traceability, legibility, and contemporaneity, and is either original data or a true copy, and is accurate." It also ensures that pharmaceuticals meet the required quality standards. DWS is the optimal software for ensuring data integrity in dissolution testing. It supports access management, data tampering prevention, and backup, allowing for the management and control of dissolution testers and their peripheral devices with just this one software, making complex methods and data management easier to handle.

• Dissolution Tester

In spatial biology/spatial proteomics research, the coexistence of "high-quality multiplex fluorescence image acquisition" and "reliable quantitative analysis" is becoming increasingly important. This webinar, co-hosted by Thermo Fisher Scientific and Indica Labs, will introduce a practical workflow that allows for a comprehensive understanding from imaging to analysis. Recommended for: - Those interested in spatial biology/spatial proteomics research who want to systematically understand the entire process from imaging to analysis. - Those who are already conducting or considering the implementation of multiplex imaging (multiplex immunostaining). - Those who feel limited by traditional four-color fluorescence observation and wish to engage in higher-dimensional spatial information analysis. This is a free seminar, so please join us. *For research use only. Not for diagnostic use.

Cancer Biomarker Discovery 2026 is an online seminar focused on the latest biomarker discovery and analysis technologies in the field of cancer research. Advanced technologies that support the understanding, diagnosis, and treatment research of cancer, such as liquid biopsy, proteomics, and spatial omics analysis, will be introduced. This seminar primarily targets basic and clinical researchers involved in cancer research, as well as those interested in biomarker discovery and analysis. In our section, we will introduce the latest techniques in fluorescent imaging for spatial biology and spatial proteomics research, centered around the Invitrogen EVOS S1000 Spatial Imaging System. Unlike traditional microscopy, which is limited in multiplex immunostaining, our spectral unmixing technology enables simultaneous imaging of up to 9 colors, allowing for rapid data acquisition with minimized sample damage. Additionally, we will explain a practical workflow using direct conjugate antibodies and TSA-based Invitrogen Aluora amplification reagents, proposing high-reproducibility analysis methods that leverage spatial information. For research use only. Not for diagnostic use.

[Speaker] Shinya Okimoto, Founder & CEO of Okiwa Studio LLC [Lecture Topics] Part 1: The tectonic shifts in the display industry and the market potential of QDEL Part 2: Business solutions to the "three major technical challenges" for the practical application of QDEL Part 3: Winning strategies for Japanese companies: Targeting the "high value-added components" sector Part 4: Redefining the business portfolio towards 2030 Part 5: Q&A

[Lecturer] Mr. Kenji Kimura, Chief Researcher, Nuclear Group, Power Unit, Japan Energy Economics Research Institute (JEA), and Research Strategy Group, Research Strategy Unit [Key Lecture Content] In recent years, the role of nuclear power has been highlighted in the context of global warming countermeasures and energy security, and more recently, in response to the increased electricity demand due to the use of AI and the expansion of data centers. Under these circumstances, new movements are being observed in countries that utilize nuclear power. In the United States, investments in nuclear power by IT companies are becoming more active, while in Europe, measures are being promoted to enhance the feasibility of new projects. In Japan, the role of nuclear power has been clarified once again, and discussions surrounding specific institutional measures are gradually progressing. This lecture will provide an overview of these movements and organize the trends that should be noted in the future. [Lecture Items] 1. Global Situation and Nuclear Power 2. Trends in Other Countries 3. Trends in New Reactor Development 4. Domestic Trends and Challenges 5. Key Points to Watch After 2026 6. Q&A / Business Card Exchange

At our booth, we will mainly showcase the following products: 〇 Our original product T-Arm 〇 Tecnospiro's product Spider 〇 Knight Global's product Air Balancer 〇 A drone for equipment inspections ▽------------------------------------------------------------▽ From April 8 (Wednesday) to April 10 (Friday) at Port Messe Nagoya ■ Manufacturing World Nagoya (Booth Number: 16-40) https://www.manufacturing-world.jp/nagoya/ja-jp.html ■ Pre-registration for attendance is convenient! https://www.manufacturing-world.jp/nagoya/ja-jp/register.html?code=1603005193330205-52G △------------------------------------------------------------△ We look forward to your visit.