UpCell Campaign

No need for trypsin! Macrophages and others are collected intact. The temperature-responsive culture equipment UpCell has "grid walls" arranged at 3mm intervals.

◆The temperature-responsive culture device UpCell for cell recovery is equipped with "grid walls" placed at 3mm intervals. ◆It has become easier to recover cultured cells in single cell/small colony form. ◆The grid wall is a new technology that prevents cells from proliferating beyond the grid by using optimized grooves on the surface of the culture dish. Cells can be recovered intact with just a short time and temperature treatment. Advantages of RepCell - It is known that trypsin significantly damages cell viability, but with RepCell, it is possible to recover cells while maintaining surface antigens and extracellular matrix. - Cell detachment using only temperature treatment The only necessary procedure for cell recovery is temperature treatment, eliminating the need for cumbersome pipetting operations associated with traditional trypsin use. For more details, please contact us or refer to the catalog.

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UpCell dedicated cell sheet stacking device. Stacking of sheets becomes easy. Demo unit available.

Features of CellStamp ● Utilizes the adhesion of gelatin gel and cell sheets for layering * ● Can be sterilized by autoclaving ** ● Compatible with UpCell 3.5 cm dishes and 24-well multi-wells

• Other physicochemical equipment

Live demonstration available! While culturing cells, we will measure the TER (transepithelial/endothelial resistance) and Ccl (capacitance) of the cell layer in real-time.

Features 1) Measurement possible while culturing cells: Long-term measurements can be conducted with the cell module placed inside the incubator. 2) Medium exchange and addition of reagents possible: The module can be removed from the incubator for operations. 3) Compatible with cell culture inserts from various manufacturers: Provides optimized medium volume for each company's inserts. 4) Each electrode is independent: Measurement of up to 24 samples is possible. (+/2) Cleaning the electrodes is easy, and inserts of different sizes can also be used. Specification of the electrodes to be measured is possible. Demonstrations are available. For more details, please contact us or refer to the catalog. You can also watch an introduction video of cellZscope on our YouTube channel.

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At our cell culture center, we conduct contract services related to cell sheet manufacturing, facility operation, and the preparation of application documents.

Features of Regenerative Medicine Contract Services 1. Development and Contract Manufacturing of Cell Sheet Products We provide contract development and manufacturing services primarily for cell sheets, commissioned by pharmaceutical companies and research institutions. Our team includes clinical culture specialists certified by the Japanese Society for Regenerative Medicine, and we offer high-quality cell sheet product development and manufacturing using experienced staff in a cell culture processing facility licensed for the production of specific cell processed products. 2. Facility Management and Application Support The "Act on Securing Safety for Regenerative Medicine" stipulates the structure, equipment, and operation of cell processing, requiring each cell culture processing facility to submit notifications and applications for permits to the Minister of Health, Labour and Welfare. At CellSeed, we assist with the notification and application documentation for the manufacture of specific cell processed products, as well as the creation of necessary operational documents. Additionally, we support the necessary administrative procedures, including the preparation of consultation materials for authorities regarding applications such as clinical trial notifications. 3. Education for Cell Culture Technicians We conduct training for cell culture technicians who have no prior experience with cell sheets, covering procedures such as cell sheet culture and detachment at our cell culture facility. For more details, please contact us or refer to our catalog.

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Live demonstration available! The difference compared to metal heating plates is clear!

It is a transparent heating element made of specially processed hard glass. It improves work efficiency in clean benches for tasks such as microscope observation and media exchange using UpCell/RepCell. Temperature settings are possible from room temperature to 50°C. It is lightweight (approximately 70g) and suitable for portability. It can also be used to cover petri dishes and multi-well plates to prevent fogging during photography. Demonstrations are available. For more details, please contact us or refer to the catalog.

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It is possible to collect mesenchymal stem cells, dendritic cells, macrophages, and cell sheets without using trypsin and without causing damage.

- Celsid's Technology By utilizing a unique nano-surface design, temperature-responsive polymer (PIPAAm) has been immobilized on the surface of the equipment. This allows the surface to change from hydrophobic (cell-adhesive surface) to hydrophilic (cell-releasing surface) by lowering the surface temperature around 32°C. Without using any enzymes that can damage cells, such as trypsin, intact cells can be recovered simply by setting the equipment temperature to 20-25°C and waiting for about 10-30 minutes. - Benefits 1) Easy cell recovery through temperature control. 2) Recovered cells completely retain the extracellular matrix. 3) No need for trypsin, which can harm cells. 4) Suitable for culturing tissues used in regenerative medicine research. 5) For 3D culture by stacking homo/heterogeneous cell sheets. For more details, please contact us or refer to the catalog.

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Complete suppression of cell adhesion in cell culture.

By applying our unique nano-surface design technology, we have fixed (covalently bonded) superhydrophilic polymers to the surfaces of our equipment. In addition to being superhydrophilic, this polymer creates a free water film. The double effect of "superhydrophilicity" and "free water" has achieved a level of low adhesion performance that far surpasses conventional low-adhesion equipment. For more details, please contact us or refer to our catalog.

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Sample presentation available! Cell sheets can be easily collected and transplanted. We use materials that are gentle on cells.

Features Dedicated cell sheet recovery support "CellShifter" for UpCell Utilizes a material with flexibility and water absorption suitable for cell detachment that could not be achieved with hydrophilic PVDF membranes or nitrocellulose membranes. This allows for the reliable and easy recovery of your precious cell sheets that have been carefully cultured with UpCell. The CellShifter, with the cell sheet adhered to it, boasts excellent ease of handling when transplanted directly to the host. Thanks to the specially treated material, there are almost no detached fibers. We guarantee maximum experimental results. Please take this opportunity to experience the results of years of material development.

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JOHNAN has released a video that clearly explains the implementation technology for stretchable films, which are expected to be utilized in wearable devices and medical equipment. In the video, you can see how the film, which has excellent elasticity, stretches and contracts. Please check our high technological capabilities and the flexible characteristics that are useful for product development. We hope this will help you generate new ideas in product development. ▼You can watch the video here [Link to the implementation page for stretchable films] https://www.johnan.com/dms/mounting/filmdevic/stretchable/

Based on practical experience in support companies and business companies, SBS Marketing Co., Ltd. provides consulting services related to marketing, sales promotion, and customer attraction mainly in the BtoB (business-to-business) sector. On August 7, 2025 (Thursday), they published a page titled "Can You Leave an 'Impact' in Business Meetings and Presentations!? 'Echoic Memory'". 'Echoic Memory' is the temporary storage of auditory information received through the ears. The page explains the mechanisms and examples of its occurrence, the differences from 'Iconic Memory', points to maximize its effectiveness, and advanced utilization techniques. (Page Overview: Excerpts) ■ What is 'Echoic Memory'? ■ The mechanism of 'Echoic Memory' and familiar examples ■ 'Echoic Memory' and 'Iconic Memory' ■ Examples of utilization in business scenes ■ Four points to maximize the effectiveness of 'Echoic Memory' ■ Advanced utilization techniques for 'Echoic Memory' (DL content only) ▼ For more details, please visit this page. https://sbsmarketing.co.jp/blog/echoic-memory-2025-08/

We would like to inform you that our company has recorded a special loss (executive retirement benefits) for the first half of the fiscal year ending December 2025, as detailed below. Furthermore, the payment of executive retirement benefits was approved at the "51st Annual General Meeting of Shareholders" held on March 28, 2025. 1. Recording of Special Loss In recognition of the long-standing contributions of one retiring director, we have recorded a special loss of 14,045 thousand yen as executive retirement benefits. 2. Impact on Performance The impact of this matter on the performance forecast for the fiscal year ending December 2025 is minimal. End.

We will disclose the interim financial results for the fiscal period ending December 2025.

As part of the "Hometown Ibara Future Creation Human Resource Development Project," we welcomed local elementary and middle school students to the special summer program "Ibara Job Exploration Tour 2025," a collaboration between the Ibara City Chamber of Commerce and the Corporate Branding Committee. We conducted a presentation that clearly and enjoyably introduced how our technology supports society, allowing the children to learn about the appeal of manufacturing and the significance of working while interacting with actual devices and products. Through this initiative, we hope to deepen our connection with the community and nurture the curiosity of the children who will carry the future. We sincerely thank everyone who participated, as well as all those involved in planning and organizing the event.