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  4. Product Introduction: Purification of Cellufine Phosphate/RNA Polymerase
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  • Jun 23, 2022
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Jun 23, 2022

Product Introduction: Purification of Cellufine Phosphate/RNA Polymerase

JNC JNC
We have published application data on the efficient purification of T7 RNA polymerase, which is essential for the synthesis of mRNA drugs, using Cellufine Sulfate (chromatography resin). Please utilize it for the purification of T7 RNA polymerase and RNA-binding proteins, which are indispensable for synthesizing mRNA drugs. In the manufacturing process of mRNA vaccines, which have become well-known as vaccines for COVID-19, T7 RNA polymerase is used as the enzyme for mRNA synthesis. Cellufine Phosphate is an affinity chromatography resin that has an affinity for nucleic acid-binding proteins. T7 RNA polymerase, being a nucleic acid-binding protein, can be efficiently purified using Cellufine Phosphate. *For more details, please feel free to contact us.
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[Technical Column] Case Study of Purification of T7 RNA Polymerase Using Cellfine Phosphate

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Cellufine phosphate / purification of RNA polymerase

It is an affinity chromatography resin that efficiently purifies the important T7 RNA polymerase used in the synthesis of mRNA drugs.

Cellufine Phosphate is an affinity chromatography resin that has an affinity for nucleic acid-binding proteins. T7 RNA polymerase can be efficiently purified using Cellufine Phosphate due to its nature as a nucleic acid-binding protein. T7 RNA polymerase is an RNA synthesis enzyme used to produce mRNA from DNA templates. In the manufacturing process of mRNA vaccines, which became famous as a vaccine for the novel coronavirus disease (COVID-19), T7 RNA polymerase is used as the enzyme for mRNA synthesis. T7 RNA polymerase can be purified to high purity through a two-step purification process using Cellufine Phosphate and Cellufine MAX DEAE (a weak anion exchange support). *For more details, please refer to the PDF document or feel free to contact us.

  • Other purification and extraction

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Biopharmaceutical chromatography packing material "Cellufine"

It is a chromatography resin for the purification of domestically produced biopharmaceuticals. We provide high-performance products backed by over 40 years of manufacturing experience in a stable manner.

"Cellufine" is a resin to chromatography used for the purification of antibody drugs such as monoclonal antibodies, biopharmaceuticals like proteins and enzymes, vaccines, virus particles, and food additives. Due to its spherical cellulose particles, it has mechanical strength and high biocompatibility, making it widely used for the purification of biopharmaceuticals. With over 40 years of manufacturing experience, it has been adopted by global pharmaceutical companies around the world. Additionally, as it is derived from natural polysaccharides, it has a lower level of leachables compared to synthetic polymers. 【Features】 - Adopted by pharmaceutical companies worldwide for the purification of biopharmaceuticals - Can be operated at high flow rates - High adsorption performance allows for cost improvements in the manufacturing process - Lower leachables compared to synthetic polymers due to being made from natural polysaccharides - Manufactured under an ISO9001 quality system *For more details, please refer to the PDF document or feel free to contact us.

  • Chromatography

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[Technical Column] A Case Study on the Purification of T7 RNA Polymerase Using Selfine Phosphate

[Technical Column] A Case Study on the Purification of T7 RNA Polymerase Using Selfine Phosphate

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Chromatography packing material "Cellfine"

Chromatography packing material "Cellfine"

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[Cast Prototype] 3D Printer Molding Prototype with Cast Sand Molds

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● The production time for casting prototypes can be shortened! Since model making is not required, the production time for prototypes, which previously took about a month, can be significantly reduced. ● Model costs can be reduced! By directly creating sand molds from 3D data, there is no need for model production costs. If changes to the model are necessary, they can be addressed by modifying the 3D data. ● Similar products with different shapes and dimensions can be prototyped simultaneously! Different products, such as similar shapes or variations in dimensions, can be created in a single molding process. This allows for the verification of multiple types in a short period.

Mar 27, 2026

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Casting prototype and casting repair.

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The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without affecting the base material with heat. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

Mar 27, 2026

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Realizing strict access control with high-speed facial recognition and impersonation prevention using edge AI.

High-speed facial recognition and spoof prevention using edge AI enables strict access control management, with FaceMe Security supporting VIA Technologies' access control device "ACS-5000."

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This time, the ACS-5000 is available as a facial recognition terminal compatible with FaceMe Security's add-on feature "Face Terminal," enabling access control management that combines "advanced anti-spoofing features" with high-speed facial recognition powered by edge AI. ■ Main Features 1. Accelerated Authentication Processing FaceMe Security is optimized for the MediaTek Genio 700's NPU, achieving faster facial recognition processing and reduced CPU load compared to processing solely on the CPU. It ensures stable authentication without delays even during peak times such as clocking in and out, contributing to alleviating congestion. 2. Advanced "Anti-Spoofing" Optimized for the IR + RGB camera mounted on the ACS-5000, it can quickly detect fraudulent authentication using photos, videos, or 3D masks within 0.6 seconds, ensuring reliable identity verification. 3. Door Control Without Additional Equipment FaceMe Security can directly control the digital I/O of the ACS-5000, allowing for the construction of an access control management system without the need for additional equipment. This simplifies system configuration and reduces implementation costs.

Mar 27, 2026

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■■ Air leak tester for EV (electric vehicle) battery cases | FLZ-0630 series ■■ Reduces noise. Measurement is performed using a newly developed smoothing function and linear fitting correction function.

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This is an air leak tester for battery cases of electric vehicles (EVs). The battery case has the characteristic of being "large with a significant internal volume, and its structure may deform due to internal pressure." As a result, air leak testing generates "noise caused by its large size and capacity" and "noise caused by expansion or deformation due to internal pressurization." To mitigate this noise, this device features a newly developed smoothing function and a linear fitting correction function used in combination during measurement. Additionally, to achieve low-pressure control that is difficult to manage and to expand flow for large volumes, we provide a bypass box (CBU-600) equipped with an electro-pneumatic regulator for precise pressure control and a pressurization valve with a large effective diameter to supply high flow rates. Measurement methods: Work-Work comparison, Work-Master comparison, Fixed Master comparison Measurement pressure range: 10 kPa, 20 kPa, 50 kPa (depending on specifications) Gauge pressure sensor accuracy: ±2% F.S. Differential pressure sensor accuracy: ±0.5% F.S. Group settings: 0 to 31 groups Power supply voltage / Power consumption: AC100 to 240 V / 100 VA

Mar 27, 2026

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PFAS Regulation Countermeasures! ■■ Leak Test Equipment for Small Electronic Components|MSA-0101 series ■■ Does not use fluorinated inert fluids. PFAS-free. Offers accuracy equal to or better than liquid immersion testing.

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● This is a leak testing device for small electronic components that does not use fluorinated inert liquids (PFAS-free). ● There is no longer a need for unstable visual confirmation through liquid immersion testing. It adopts a quantitative testing method that allows for stable pressure leak testing. ● It is a tabletop leak testing device specifically for gross leaks, with accuracy equal to or greater than that of liquid immersion testing. ● The detectable range is approximately 1×10⁻² Pa·m³/s to 1×10⁻⁶ Pa·m³/s (varies depending on the target product). ● It is suitable for sealed structures ranging from a few millimeters to a maximum of 80 × 70 mm. Please feel free to contact us for more information!

Mar 27, 2026

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