Introduction of animal models for research on photoreceptor protection, retinal and visual regeneration, and retinal pigmentary degeneration (RCS) rats.
The Royal College of Surgeons (RCS) rat, a model for retinal pigment degeneration, is the first known model of hereditary retinal degeneration. It has been widely used in research on hereditary retinal dystrophies. Since April 2016, Japan Crea has started general sales. For more details, please check from [Download Catalog]. *You can easily make inquiries using a simpler email form than on our company website. (Search for "Japan Crea")
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basic information
Features: ■ Although the retina is normally formed after birth, degeneration of photoreceptor cells begins around three weeks after birth, and by around three months, most photoreceptor cells have disappeared. ■ Shows abnormalities in the phagocytic ability of retinal pigment epithelium cells regarding the outer segments of photoreceptor cells. ■ Causes retinal degeneration in a recessive inheritance pattern. ■ Has a deletion mutation in the Mertk gene. ■ Widely used as a model for retinal degenerative diseases. For more details, please refer to the [Download Catalog]. *You can easily make inquiries using a simpler email form than our company website. (Search for "Nihon Kurea")
Price information
Details are available in the catalog. Please refer to it.
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※The delivery date may vary due to breeding. Please contact us.
Applications/Examples of results
■Examples of Photoreceptor Protection Research: Protection of Retinal Degeneration by Growth Factor Administration Basic fibroblast growth factor (bFGF, 1μg/μl) was administered into the vitreous of 23-day-old RCS rats. As a result, the treated group showed an observable photoreceptor layer, confirming a delay in degeneration. (Pathological photos are explained in the catalog) ■Examples of Retinal (Visual) Regeneration Research: Visual Restoration Using Optogenetics The ChR2 gene was introduced into the ganglion cells of RCS rats that had lost their photoreceptors and become blind, restoring visual function. (Pathological photos and graphs are explained in the catalog) For more details, please check the 【Download Catalog】.
Detailed information
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Retinal Pigment Degeneration Model RCS Rat Price List (Excluding Tax) For orders of RCS rats, please contact the AD Order Center TEL: 03-5704-7123 Order-only email: adorder@clea-japan.com For more details, please check [Download Catalog].
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Company information
Nihon Kurea Co., Ltd. is a company primarily engaged in the production and sale of laboratory animals, the manufacture and sale of laboratory animal feed, and the manufacture and sale of laboratory animal housing equipment, tools, facilities, and devices. In response to research using laboratory animals, we have been working on the development and improvement of various types of laboratory animal feed. Currently, there are 15 different brands available. These feeds are supplied under strict management from the procurement of raw materials to formulation, manufacturing, product inspection, storage, and transportation, in accordance with the regulations of the "Nihon Kurea Co., Ltd. Business Standards for Management Criteria Related to Laboratory Animal Feed," with the aim of maintaining consistently stable quality and improving reliability.