Contracted production of genetically modified mice: Conditional knockout mice

Conditional knockout has become a very useful method for analyzing gene function.

Our company is engaged in the production of "conditional knockout mice." Conditional knockout, also known as condition-specific gene disruption, is a method that involves creating mice with a gene locus flanked by the Cre recombinase target sequence loxP, which targets a specific gene region. By crossing these mice with mice that express Cre recombinase in a tissue- and time-specific manner, we can induce the disruption of the target gene only in specific tissues and at specific times. In recent years, various Cre-expressing mice have been developed, including those that induce activity through drugs (such as CreER), making conditional knockout a very useful method for analyzing gene function. 【Features】 - Possesses loxP sequences, allowing gene disruption through the expression of Cre recombinase. - Enables the analysis of lethal genes. - Allows for tissue-specific gene disruption. - Enables time-specific gene disruption. - We also accept the production of mice from targeting vectors from KOMP and EUCOMM. *For more details, please refer to the PDF materials or feel free to contact us.

Animal cells