An online TOC analyzer that adopts the "gas permeable membrane conductivity measurement technique" in accordance with the Japanese Pharmacopoeia General Test Method <2.59 Organic Carbon Test Method>.
The online TOC analyzer Sievers M500 is the third generation of online TOC analyzers that has developed Sievers' long-standing reagent-free gas permeable membrane conductivity measurement technology. While inheriting the conventional "accuracy," "reproducibility," and "stability," it has achieved rapid measurement and enhanced data management functions. 【Unique technology compliant with the Japanese Pharmacopoeia】 - Complies with the Japanese Pharmacopoeia General Test Method <2.59 Organic Carbon Test> - Complies with various national pharmacopoeias (USP <643>, EP 2.2.44) - Measures by separating carbon dioxide: gas permeable membrane conductivity measurement method - Calibration using potassium hydrogen phthalate - Detects sodium dodecylbenzenesulfonate with a recovery rate of over 90% 【High performance & high functionality】 - Real-time measurement at 3-minute intervals - Flexible sampling functions - Abundant system protocols - Data integrity compliant with 21 CFR Part 11
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【TOC】 Measurement Principle: Ultraviolet Oxidation + Gas Permeable Membrane Conductivity Measurement Method Measurement Range: 0.03 to 2,500 ppb TOC Detection Limit: 0.03 ppb Quantification Limit: 0.1 ppb Accuracy: ±5% of the measured value or ±0.1 ppb, whichever is larger Reproducibility: ±1% of the measured value or ±0.03 ppb, whichever is larger 【Conductivity】 Measurement Range: 0.01 to 800 μS/cm Accuracy: ±1% or ±0.005 μS/cm, whichever is larger Reproducibility: Within 1.0%
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**Real-Time Testing of Pharmaceutical Water** Real-time testing of TOC and conductivity using Process Analytical Technology (PAT) enables a better understanding and control of the pharmaceutical water system, improving quality and productivity. PAT utilizes real-time measurement data to design, analyze, and manage processes, ensuring product quality. To maximize the benefits of PAT, validation of the analytical method for TOC meters is necessary. The Sievers M500 provides documentation and standard solutions to support the implementation of analytical method validation. Adopting real-time testing for pharmaceutical water offers the following benefits: - Reduction of costs/resources/contamination/lab errors/data delays associated with traditional lab analysis - Real-time detection of out-of-specification and out-of-trend test results - Root cause analysis utilizing TOC/inorganic carbon/conductivity - Technology transfer from lab testing to online testing using Sievers TOC measurement technology.
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"Selectivity of Carbon Dioxide Using Sievers' Unique Gas Permeable Membrane Conductivity Measurement Method" In the TOC measurement method, the conductivity indicated by the carbon dioxide (carbonate ions) generated after the oxidation and decomposition of organic matter is measured to calculate the carbon concentration. The Sievers M500 enables accurate TOC measurement by using a carbon dioxide separation measurement mechanism called the "gas permeable membrane module," which separates carbon dioxide from the sample water to the pure water line within the analyzer using a Teflon thin film, thereby eliminating the influence of other ions.
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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.
