For screening cell culture conditions! For process development in microbial fermentation, C1 gas fermentation, cell culture, experimental design research, and early-stage experiments!
Compact system that effectively utilizes bench space – Suitable for robot integration – Selection of reactor sizes and types, including high-pressure designs (5 bar or 10 bar options) – Parallel processing of up to 8 independent reactors. A single PC can control up to 48 reactors – Offers a variety of compatible bioreactors – Reusable glass bioreactors suitable for a wide range of applications at atmospheric pressure – Stainless steel reactors for standard or high-pressure fermentation (up to 10 bar / 145 PSI) – Specially designed head plate compatible with all probes and feeds – Working volumes from 20 ml to 150 ml – Bioreactor shape that mimics large-scale systems
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basic information
Gas Supply - Choose from simple or more sophisticated gas flow control methods - Each bioreactor consists of one or more mass flow controllers - For microbial fermentation, automatic oxygen enrichment is available - In cell culture applications, CO2 is used for pH control - Online feedback from off-gas analysis allows for mixing and adjusting the ratios of multiple gases Liquid Supply - Options for liquid supply for standard and pressure applications - A highly linear peristaltic pump drive is integrated into the standard head, enabling excellent pH and dosage control, as well as a wide operating range - Typically, 2 to 4 pumps are supplied per reactor, with additional pumps added as needed - Syringe pumps and high-pressure pumps are also available in the lineup Magnetic Suspension Stirring - Ideal for small bioreactors with proven performance - No shaft seals or moving parts: no issues with sterility - Excellent magnetic coupling - Various stirrer designs (marine, Rushton, etc.) - Speed options from 300 rpm to 1500 rpm or 30 rpm to 200 rpm
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Applications/Examples of results
The H.E.L control software WinISO enables the BioXplorer 100 system to run complex fully automated experiments unattended. This allows for: - Multi-reactor control with unlimited step recipe planning. Plans can be modified online at any time without interrupting the process. - Individual or simultaneous start and stop of reactors. - User-defined data logging with customizable table and graphic displays. - Data export functionality and integration with in-house electronic lab notebooks and record management systems. - Integration of DoE and QbD packages. Specifically, the software controls a wide range of system functions such as: - Temperature - Gas supply, flow, and mixing - pH - Dissolved oxygen - Redox - Stirring speed - Torque (for viscosity display) - Pressure - Liquid supply amount - Foam control and level detection.
Company information
Aivic Research was established with the aim of contributing to the improvement of healthcare by helping to enhance the data accuracy of dissolution testing through the provision of excellent dissolution testers and dissolution tester inspection services, as well as introducing the latest dissolution testing information by utilizing various pipes from overseas, thereby supporting the development of the pharmaceutical industry in Japan.
