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  6. BioSMB PD System

BioSMB PD System

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last updated:Nov 06, 2025

Sartorius Stedim Japan K.K.
Sartorius Stedim Japan K.K.
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Continuous production single-use multi-column chromatography

**Features** - The efficiency of the unit operations inherent in the BioSMB PD system allows for a reduction of up to 80% in the cost of media in chromatography without changing the resins or buffers used in the chromatography process. - All chromatography processes can be conducted with only a fraction of the media and buffers required to obtain the same amount of substance in a conventional batch process. - The ability to use up to 16 columns enhances productivity and application flexibility. - By installing a buffer selection valve, composition gradients and cleaning steps are unnecessary. *You can watch the webinar at the following URL:* https://bit.ly/3yaB65S *title: 'Virtual Demonstration and Conceptual Overview of the BioSMB Multi-Column Chromatography Platform'*

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BioSMB PD System

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The BioSMB platform is a fully scalable continuous production multi-column chromatography solution that enables process development (PD) in the lab to GMP manufacturing through disposable flow paths. It is specially designed to convert continuous production chromatography without changing chromatography resins, buffer systems, or product quality testing from existing batch processes. The BioSMB technology provides process consistency across all scales, including development, clinical, and full production, and allows for flexible use in a variety of product facilities.

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BioSMB PD System

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White Paper "Promoting Environmental Sustainability in the Biopharmaceutical Industry"

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[On-Demand Streaming Available] 10/6 (Wed) International Webinar 'Simplifying the mRNA Process_Part 2: Why Multi-Column Chromatography is Superior to Batch_Throughput Analysis'

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Participation in this webinar has ended. Those who wish to view it on demand can register for details and access it after registration. The mRNA vaccine plays a crucial role in combating SARS-CoV-2, and the necessity to produce mRNA has never been greater due to the ongoing development of treatments for various indications. In Part 2, the product manager and product specialist of the BioSMB system will explain how multi-column chromatography is superior to batch chromatography and how it can increase throughput by up to six times. They will also introduce traditional batch processes and demonstrate how BioSMB can be easily integrated into existing processes without compromising purification performance, throughput, or quality. [Topics] ▪ How batch chromatography limits throughput and increases resin costs ▪ How to improve throughput with less resin using BioSMB's multi-column cycling ▪ An analysis of how increased throughput reduces time to scale-up and the facility footprint.

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Sartorius

Sartorius Stedim Japan K.K.

Pharmaceuticals and Biotechnology

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Sartorius Stedim, established in 2007 through the merger of the German company Sartorius, founded in 1870, and the French company Stedim, is a pioneer in "Single-Use Technology (SUT)." As a company capable of providing comprehensive technical support to the pharmaceutical and biotechnology industries, its cutting-edge technology is highly regarded worldwide in the fields of scientific instruments and biotechnology.

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