Skin microbiome, promotion of antimicrobial peptide production, anti-inflammatory effects, barrier function recovery effects, enhancement of tight junction barrier function.
BIOTILYS enhances the expression of antimicrobial peptides, improving antibacterial activity, anti-inflammatory effects, barrier function recovery, and the diversity of the skin microbiome. <Effects of Antimicrobial Peptides> - Antimicrobial peptides have a broad range of antibacterial activity and have been reported to exhibit antibacterial activity against Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa, and even drug-resistant bacteria. - They have also been confirmed to improve tight junction barrier function and have anti-inflammatory effects on the skin, showing promise for the treatment of atopic dermatitis and psoriasis. <Stimuli for Antimicrobial Peptide Expression> - β-defensin 2 (hBD2): +229% - β-defensin 3 (hBD3): +19% - S100A7 (soriacin): +237% <Anti-inflammatory> - Toll-like receptor 2 (TLR2): -57% - IL-8: -58% <In Vivo: Barrier Function Recovery Effects> - Water vapor loss: -31% (after 6 hours) - Moisturizing function: +27% (after 3 hours) - Improvement in the diversity of the skin microbiome
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Green Tech Co., Ltd. is a company established in 1992. The company has been importing and selling various types of plant extracts in Japan for about 20 years, and we have heard that Japanese customers perceive Green Tech as a manufacturer with a wide range of plant extracts. In fact, the company handles over 5,000 types of plant extracts. In addition to conventional plant extracts, we also produce and sell products focused on the biodiversity of South America, particularly Brazil, including plant extracts and oils, as well as products developed based on microbiome research that demonstrate effectiveness in maintaining microbial community homeostasis, and components and extracted extracts derived from algae and microalgae. In recent years, we have been focusing on research and development, not only enhancing the evaluation data of our products in In-Vivo and In-Vitro studies but also conducting research and development in response to new trends such as skin microbiome, circadian rhythm, and senescent cells. Additionally, we are committed to the development and manufacturing of products that have demonstrated effectiveness by increasing the concentration of active ingredients using our proprietary freeze technology (preservation, grinding, extraction) and fermentation technology. These manufacturing technologies support not only the development of our own products but also the development of customized products.
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Recommended addition amount: 1-5% Recommended usage pH: 4.0 - 10.0 Appearance: Transparent aqueous solution, yellow to beige Solubility: Soluble in water up to 10% Addition is recommended in cold processes. - Protection and repair products - Products for dry skin - Moisturizing products - Microbiome support
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Starting as an import trading company in 1927, we have been developing our business with many overseas suppliers and domestic customers over the years. Through our services of connecting the two together, Higuchi has become the well trusted "Japan distribution channel" for suppliers, and the "dependable vendor" who provides a stable supply of the latest high-valued overseas products to customers. Today, we conduct not only importing but also exporting businesses, trilateral trades, and overseas business investments as well. We have also expanded to local subsidiaries in the United States and China, to which we are able to effectively network overseas. Higuchi believes in the criticalness of providing a stable supply to customers, and we also place the highest priority on the coexistence with suppliers, to whom we can mutually develop together in a long-term perspective. Your support and consideration to our corporate philosophy would be much appreciated.