High-capacity PCR device capable of mass-producing DNA.

basic information

Instead of the currently mainstream DNA production using E. coli culture, large amounts of DNA can be produced quickly using clean PCR. 【Device Configuration】 - High-capacity dedicated thermal cycler - High-capacity dedicated reaction liquid bags - High-capacity dedicated reaction liquid (heat-resistant polymerase, etc.) 【Breakthrough Technology】 - For large-scale PCR, two technologies are required: a device that can accurately control the temperature cycles of a large volume (e.g., 200 mL) of reaction liquid, and a reaction liquid that can perform PCR even with slow temperature changes. - Researchers from Yamaguchi University and a local kamaboko manufacturing equipment company have collaborated for many years to achieve the best match through improvements to the PCR device and adjustments to the reaction liquid. - As a result, it has become possible to conduct PCR with 200 mL of reaction liquid at once. - For the reaction liquid, which tends to be costly in PCR, a low-cost reaction liquid suitable for large-scale PCR has been developed. Patent Application No. 2017-034496 "Thermal Cycler" Patent Application No. 2020-202035 "Nucleic Acid Amplification Method and Thermal Cycler"

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Applications/Examples of results

【Application Areas】 - DNA drug manufacturing - DNA vaccine manufacturing - DNA reagent manufacturing - Manufacturing of products containing DNA