Protein and Nucleic Acid Quality Evaluation Device 'STUNNER'

Unchained Labs, Inc. will be exhibiting at the 4th Annual Meeting of the Japanese Society for Antibody Research, which will be held from December 1 (Monday). At our booth, we will introduce innovative tools essential for antibody and ADC research, such as Aunty, a device for evaluating protein structural stability, and Stunner, which can measure various parameters including potency and size. We look forward to seeing you in Omiya! Exhibition details: ■ Dates: December 1 (Monday) to 3 (Wednesday), 2025 ■ Venue: Omiya Sonic City

The analysis of antibodies and antibody-drug conjugates (ADCs) is no longer a headache. Stunner measures the concentration, size, and aggregation of antibodies using just 2 µL of sample in 2 minutes, processing up to 96 samples in a single run. In this webinar, we will detail how Stunner's Unmix software separates the signals of antibodies and drugs, allowing for the rapid quantification of protein amount, drug amount, and drug-antibody ratio (DAR). Be sure to see how Stunner streamlines the cumbersome ADC characterization process.

The development of lipid nanoparticles (LNPs) requires flexible tools that can consistently handle everything from screening to GMP manufacturing. An ideal manufacturing tool must accommodate small-scale, user-friendly experiments as well as multi-parameter, multi-sample, and even large-scale continuous operations. However, the creation of lipid nanoparticles (LNPs) is only half the goal; evaluating characteristics such as encapsulation efficiency (EE%), payload quantification, particle size, and PDI is also essential. Our Sunshine series and Stunner AF (Add Fluorescence) enable scalable nanoparticle manufacturing and powerful all-in-one characterization. In this webinar, we will introduce scalable LNP manufacturing with Sunshine and one-stop measurements of EE%, total RNA quantification, particle size, PDI, and particle concentration with Stunner AF. Experience solutions that will take nanoparticle development to the next level, from research to industrial applications.

**[Issue]** The evolution of LNPs is progressing more rapidly than ever, largely due to modifications in particle formulations. However, the formulations to be tested are complex in composition and involve a vast number of combinations, making large-scale screening difficult to achieve. Furthermore, there is the subsequent challenge of transferring to production. Evaluations are also required to be accurate, comprehensive, and high-throughput. **[Webinar Overview]** In this webinar, we will explain how our Sun series can accelerate the exploration and development of LNPs, based on the latest research findings and user case studies in LNP formulations. We will also introduce Stunner, which enables high-speed and accurate LNP evaluations.