Exploration and evaluation of Olink neurobiomarkers.
Olink Explore HT, Target 96, Target 48
Multiplex Approach to Multifactorial Diseases: A New Era in Neurodegenerative Biomarker Research
Olink's neurobiomarker analysis is a proteomics method that allows for the highly sensitive and specific simultaneous measurement of neurodegenerative disease-related proteins from limited samples such as plasma, serum, and cerebrospinal fluid, using Proximity Extension Assay (PEA) technology. Olink Target 48 Neurodegeneration enables the absolute quantification of markers important in neurodegenerative disease research, such as Aß40, Aß42, pTau217, NfL, and GFAP, making it useful for longitudinal studies and inter-facility comparisons. Furthermore, by using Olink Explore HT and Target 96 Neurology, a broad protein profiling analysis including neuroinflammation and synaptic function becomes possible, supporting the identification of novel biomarkers and elucidation of pathological mechanisms. **Effects of Implementation** - Promotion of understanding disease mechanisms through comprehensive analysis of neuroinflammation-related proteins. - Increased efficiency in biomarker discovery and contribution to drug development research. - Ability to measure numerous proteins from a small amount of sample, allowing for effective use of valuable samples.
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【Target 48 Neurodegeneration Features】 - Number of proteins: 41 (validated) - Sample volume: 1 µL (plasma, serum, etc.) / panel - Specificity: 99.5% (very little cross-reactivity) - Expression value: pg/mL absolute quantification - Reading method: Quantitative PCR (Olink Signature Q100) 【Explore HT Features】 - Number of proteins: Simultaneous measurement of over 5,400 proteins - Sample volume: 2 µL (plasma, serum, etc.) / panel - Specificity: High specificity of 99.5% - Throughput: Over 2,000 samples per week - Reading method: NPX relative quantification (next-generation sequencer) 【Our Strengths】 Thermo Fisher Scientific Inc. provides cutting-edge analytical instruments, including Olink Explore HT, as a world-leading scientific services company. Our experienced staff supports customers from the consideration of experimental design tailored to research purposes and analytical needs to equipment installation and analysis services.
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Applications/Examples of results
From cohort analyses such as the UK Biobank and SCALLOP to validation in clinical research, we can consistently conduct research from exploration to bridging studies on a single platform. It is utilized for research purposes in many fields, not only in disease research but also in healthcare related to aging, by companies, research institutions, and hospitals. It cannot be used for diagnosis. 1) Neurodegenerative Diseases: Looking Beyond the Boundaries of the Brain. (2022) Front Neurosci. 2) Emerging non-traditional biomarkers for Alzheimer’s diagnosis and progression. (2025) Ageing Research Reviews Many papers can be found on the Olink website.
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Thermo Fisher Scientific K.K., the Japanese subsidiary of Thermo Fisher Scientific Incorporated, is a sales company for comprehensive system analysis instruments, bio-related equipment, and research reagents. In Japan, it has bases in Yokohama, Tokyo, Osaka, Fukuoka, and Nagoya, handling various analytical instruments including mass spectrometers, various bio-related equipment, measuring instruments, medical devices, lab software, and research reagents.
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