◆On-Demand Webinar Distribution◆ A Ray of Hope for Challenges in LNP Research and Development

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

The transition from LNP to GMP is a costly and complicated process. Typically, this requires switching equipment, using different flow paths and mixing devices, and essentially re-developing and re-validating everything that has been painstakingly done so far. With Sunbather, the transition to GMP can be done easily thanks to its recording features, interchangeable flow paths, and easily transferable design. Sunbather uses the same mixing process and protocols as the Sunscreen and Sunshine from the same Sun series, allowing for easy transition of adjusted formulation conditions to GMP. - Up to 1.8 L/h - Integrated inline dilution - Fully interchangeable flow paths - A wide variety of mixing devices - Software compliant with 21 CFR Part 11 - Process transferable from Sunshine

• Other Physics and Chemistry Equipment

[Lecturer] Professor Hiroyuki Kato, Faculty of Sociology, Department of Social Policy Science, Hosei University [Key Lecture Content] In this lecture, I will introduce perspectives on the shipbuilding industry. Japan's shipbuilding industry has a long history and can be seen as a "microcosm" of Japanese industry. Within about ten years after World War II, Japan's shipbuilding industry became the world leader in construction volume, and at one point, the construction volume of the seven major domestic companies accounted for more than half of the world's share. Although it has since been surpassed in construction volume by latecomers such as South Korea and China, it still maintains a certain level of competitiveness. Reflecting on the path taken by the shipbuilding industry, which serves as a "microcosm," the reasons for its continued strength, and the challenges it currently faces may provide insights when considering the future of various Japanese industries. [Lecture Items] 1. Characteristics of the shipbuilding industry 2. Shipyards seen through photos and videos 3. The shipbuilding industry depicted in films 4. Why is it still strong? 5. Points to consider for future developments 6. Q&A / Business card exchange

[Speaker] Maho Tanaka, Manager, Strategy Group, Business Consulting Division, Accenture Japan Ltd. [Key Lecture Content] AI is evolving beyond a mere tool for operational efficiency to become an entity responsible for execution, including information acquisition, comparison, judgment, contracts, and purchasing. As actions initiated by dialogues with general-purpose AI chatbots like ChatGPT become mainstream, corporate information is not reaching users directly, and the structure where decision-making and execution are completed on AI is rapidly expanding. In this lecture, based on this irreversible change, we will organize the reality that the competitive axis of companies is shifting from "appealing to consumers" to "how AI understands, selects, and executes." Furthermore, we will explain the key points of strategic transformation that management should consider in the era of agent-based AI, from organizing the information structure cited by AI to designing touchpoints that reclaim the initiative for judgment and execution for the company. [Lecture Items] 1. The impact of AI on information search and access 2. The impact on corporate marketing and communication 3. The ideal direction for corporate communication in the AI era 4. Introduction of our company’s case studies 5. Q&A session

The overall theme of the webinar is: "The Two Barriers Hindering Automation in Food Factories" "Case Studies on Access Control and AI Image Recognition" Our company will be the first to present. For more details, please visit our website!

[Speaker] Yuki Kobayashi, CEO/Co-Founder of MESON Inc. [Key Lecture Content] In this presentation, we will explore "AI glasses," which have recently begun to attract significant attention as the next-generation user interface, explaining their essence and business impact. We will clarify the differences from previous XR devices and organize representative products currently available, while interpreting why AI glasses are becoming a realistic option against the backdrop of the evolution of generative AI and changes in societal acceptance. Furthermore, through market expansion and case studies primarily overseas, we will demonstrate why the years 2026 to 2028 will be a turning point for technology and business, and discuss the issues and risks that Japanese companies should currently address. [Lecture Items] 1. What are AI glasses? 2. Why AI glasses now? 3. Changes happening globally 4. How AI glasses will change work 5. Experience design as a decisive factor 6. The turning point for Japanese companies (Closing) 7. Q&A / Business card exchange *The content of the lecture may change based on the latest trends.

[Speaker] Andy Mochizuki, Director, Deloitte Tohmatsu TMT Division / Monitor Deloitte [Key Lecture Content] In an era where thinking is commoditized by AI, the source of value is determined not by "information" but by "existence," that is, "the meaning of your being." This course will start from the environmental changes surrounding the AI era, exploring the concept of redesigning work in a purpose-driven manner, the type of thinking required in the AI era (QADI cycle), and delving into the absolute differentiating factor that only humans possess—"embodiment." We will update our sense of purpose in the AI era and our collaborative relationship with AI, initiating a transformation to "live anew" from here. [Lecture Items] 1. Mapping Environmental Changes - "From the Era of Information Asymmetry to the Era of Existence Asymmetry" 2. Redesigning Work in a "Purpose-Driven" Manner 3. The "Thinking Models" Necessary in the AI Era 4. The "Body" as an Absolute Differentiating Factor 5. How to "Live Anew" in the Coming AI Era 6. Q&A / Business Card Exchange