◆On-Demand Webinar Distribution◆ A Ray of Hope for Challenges in LNP Research and Development

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

The transition from LNP to GMP is a costly and complicated process. Typically, this requires switching equipment, using different flow paths and mixing devices, and essentially re-developing and re-validating everything that has been painstakingly done so far. With Sunbather, the transition to GMP can be done easily thanks to its recording features, interchangeable flow paths, and easily transferable design. Sunbather uses the same mixing process and protocols as the Sunscreen and Sunshine from the same Sun series, allowing for easy transition of adjusted formulation conditions to GMP. - Up to 1.8 L/h - Integrated inline dilution - Fully interchangeable flow paths - A wide variety of mixing devices - Software compliant with 21 CFR Part 11 - Process transferable from Sunshine

• Other Physics and Chemistry Equipment

[Key Lecture Content] 1. Expectations for Natural Hydrogen and NEDO's Efforts Towards Its Utilization New Energy and Industrial Technology Development Organization (NEDO) Innovation Strategy Center (TSC) Sustainable Energy Unit Unit Head: Mr. Haru Shigeki 1. What is natural hydrogen? 2. Why natural hydrogen now? 3. Global trends 4. Research and development at NEDO 5. NEDO's future initiatives 6. Q&A / Business card exchange 2. Trends in Hydrogen-related Markets and Domestic and International Developments Mizuho Bank Industrial Research Department Resource and Energy Team Senior Analyst: Mr. Takahashi Kōdō 1. The environment surrounding energy 2. The environment surrounding hydrogen 3. Trends in hydrogen policy in Europe and the United States 4. Initiatives in Japan 5. Measures to create demand for hydrogen 6. Q&A / Business card exchange

[Speaker] Ministry of Internal Affairs and Communications, Radio Department Mobile Communication Planning Officer Teruhiko Sato [Key Lecture Content] In April 2025, the Radio Law will be amended, introducing a new system for frequency allocation through price competition (auction) targeting frequency bands above 6GHz. In light of this, efforts are underway to aim for early allocation through price competition for the 26GHz band, with discussions ongoing regarding the specific implementation methods and rules for the price competition. In this lecture, I will explain the background and circumstances surrounding the introduction of frequency auctions (price competition), including recent trends in the overall 5G network, as well as the current status of discussions aimed at implementing Japan's first price competition. [Lecture Items] 1. Trends in the overall 5G network 2. Background and circumstances surrounding the introduction of frequency auctions (price competition) 3. Towards the implementation of price competition for the 26GHz band - Background and circumstances of the discussions - Policy for the allocation of the 26GHz band - Method of price competition - Other rules related to price competition 4. Q&A / Business card exchange

[Speaker] Mr. Takumi Matsuo, Director of the Carbon Credit Market Development Office, Tokyo Stock Exchange, Inc. [Key Lecture Content] Two years have passed since the Tokyo Stock Exchange launched the carbon credit market in October 2023, and the market environment has changed significantly. In particular, discussions are currently underway by the government regarding the details of the second phase of the GX-ETS, which will be fully operational from fiscal year 2026. From the perspective of companies subject to the system fulfilling their obligations to reduce emissions, the role of the J-Credit market at the Tokyo Stock Exchange is expected to become increasingly important. In this lecture, I will provide a broad explanation of the current state of the carbon credit market and future market outlook, taking these policy trends into account. [Lecture Items] 1. What is emissions trading? 2. GX League (Phase 1) and the Tokyo Stock Exchange Carbon Credit Market 3. Initiatives in the Tokyo Stock Exchange "Carbon Credit Market" (FY 2023 and beyond) (1) Introduction of the market maker system (J-Credit) (2) Addition of excess reduction credits to the trading targets 4. GX-ETS (Phase 2) and the Tokyo Stock Exchange Carbon Credit Market 5. Q&A / Business card exchange

The development of lipid nanoparticles (LNP) requires flexible tools that can accommodate everything from screening to GMP manufacturing. The ideal manufacturing equipment should be capable of handling a wide range of applications, from small-scale, easy-to-handle experiments to multi-parameter, multi-sample, large-scale continuous operations. Additionally, not only is the production of LNP important, but the evaluation of characteristics such as encapsulation efficiency (EE%), RNA amount, particle size, and PDI is also crucial; traditionally, these measurements have been complicated and required multiple instruments. In this webinar, we will introduce scalable LNP manufacturing by Sunshine and one-stop measurements of EE%, total RNA, particle size, PDI, and particle concentration using Stunner AF. Furthermore, you will also be able to watch a demo video showcasing the actual operation of the Sun series (Sunshine, Sunscreen) and Stunner! Instructor: Takuma Iwasaki | Field Application Scientist *This webinar is a recording of a session hosted by Unchained Labs, Inc. in October 2025.

"I want to find a way to manage the workload of addressing system integrations one by one," and "Data integration has become reliant on specific individuals, and after their departure, it ended up being left to the vendor," are among the various challenges faced in promoting data integration. As the importance of data integration increases for driving digital transformation (DX), it is essential to not only rely on external resources but also to pursue in-house development. In this seminar, Panasonic IS, which has supported data integration for over 500 companies, will provide insights on in-house development based on case studies of the data integration tool "ASTERIA Warp." This seminar is recommended for those who want to learn about utilizing no-code data integration tools and those looking to bring data integration in-house. <Recommended for> - Those who want to know the latest trends in data integration for large and medium-sized enterprises - Those who want to learn how to utilize data integration tools effectively - Those who are looking for tips on conducting data integration within their own company Target audience: Information system managers, information system personnel, DX promotion personnel.