Automatic Synthesis and Screening System for Lipid Nanoparticles Sunscreen

The development of lipid nanoparticles (LNP) requires flexible tools that can accommodate everything from screening to GMP manufacturing. The ideal manufacturing equipment should be capable of handling a wide range of applications, from small-scale, easy-to-handle experiments to multi-parameter, multi-sample, large-scale continuous operations. Additionally, not only is the production of LNP important, but the evaluation of characteristics such as encapsulation efficiency (EE%), RNA amount, particle size, and PDI is also crucial; traditionally, these measurements have been complicated and required multiple instruments. In this webinar, we will introduce scalable LNP manufacturing by Sunshine and one-stop measurements of EE%, total RNA, particle size, PDI, and particle concentration using Stunner AF. Furthermore, you will also be able to watch a demo video showcasing the actual operation of the Sun series (Sunshine, Sunscreen) and Stunner! Instructor: Takuma Iwasaki | Field Application Scientist *This webinar is a recording of a session hosted by Unchained Labs, Inc. in October 2025.

The development of lipid nanoparticles (LNPs) requires flexible tools that can consistently handle everything from screening to GMP manufacturing. An ideal manufacturing tool must accommodate small-scale, user-friendly experiments as well as multi-parameter, multi-sample, and even large-scale continuous operations. However, the creation of lipid nanoparticles (LNPs) is only half the goal; evaluating characteristics such as encapsulation efficiency (EE%), payload quantification, particle size, and PDI is also essential. Our Sunshine series and Stunner AF (Add Fluorescence) enable scalable nanoparticle manufacturing and powerful all-in-one characterization. In this webinar, we will introduce scalable LNP manufacturing with Sunshine and one-stop measurements of EE%, total RNA quantification, particle size, PDI, and particle concentration with Stunner AF. Experience solutions that will take nanoparticle development to the next level, from research to industrial applications.

**[Issue]** The evolution of LNPs is progressing more rapidly than ever, largely due to modifications in particle formulations. However, the formulations to be tested are complex in composition and involve a vast number of combinations, making large-scale screening difficult to achieve. Furthermore, there is the subsequent challenge of transferring to production. Evaluations are also required to be accurate, comprehensive, and high-throughput. **[Webinar Overview]** In this webinar, we will explain how our Sun series can accelerate the exploration and development of LNPs, based on the latest research findings and user case studies in LNP formulations. We will also introduce Stunner, which enables high-speed and accurate LNP evaluations.

Unchained Labs, Inc. will exhibit at the 41st Annual Meeting of the Japanese DDS Society, which will be held from June 17 (Tuesday). At our booth, you can see a wide range of products, from the manufacturing of lipid nanoparticles (LNP) to their characterization, as well as products for ADC and the evaluation of extracellular vesicles. Additionally, on the first day of the event, July 17, we will also hold a presentation by exhibiting companies. All of our staff sincerely look forward to your visit. Event Name: 41st Annual Meeting of the Japanese DDS Society Date: July 17 (Tuesday) - July 18 (Wednesday) Venue: Makuhari Messe International Conference Hall Details: https://procomu.jp/dds2025/ <Exhibiting Company Presentation> July 17 (Tuesday) around 15:28