We will exhibit at the DDS Society academic conference.

Accelerating formulation optimization for vaccine and pharmaceutical development.

To create the optimal LNP, it takes a tremendous amount of time and effort to examine and pursue formulation conditions. LNPs are nanoparticles composed of multiple lipids. Therefore, it is necessary to find the optimal conditions such as the mixing ratios, the ratio of lipids to payload, and the flow rates during mixing. Furthermore, we must also consider throughput issues. Sunscreen can produce up to 96 types of small LNPs within six hours, thus solving the previous throughput problems. This means that it is possible to explore a greater number of formulation condition investigations in a single day. • Fully automated execution of up to 96 types of condition investigations within six hours • 200 μL to 2 mL per experiment • Flow rate of 0.1 to 30 mL/min • Reusable microfluidic chips • Seamless scale-up through process and protocol optimization

• Other Physics and Chemistry Equipment

Efficient mass production of LNPs - Supporting everything from small-scale condition testing to scale-up.

Once we succeed in finding the optimal formulation conditions for sunscreen, let's use Sunshine to adjust the size of the LNP. Furthermore, we will optimize the protocols and processes for scaling up. We will find the ideal flow rate and explore different mixing options. Next, we will adjust these to the appropriate dilution factor that can keep them stable. Once everything is in place, Sunshine will transition to continuous mode, allowing us to produce several dozen liters in a day. In other words, we will achieve process development and scaling up on a single platform. Many researchers have likely been looking forward to the birth of such a groundbreaking system. • 10 experiments in 15 minutes • Fraction & total flow • From 1 mL to continuous flow • Flow rate 0.1 to 30 mL/min • Reusable microfluidic chips • Possible transition of protocols from sunscreen

• Other Physics and Chemistry Equipment

Accelerating formulation optimization for vaccine and pharmaceutical development.

The transition from LNP to GMP is a costly and complicated process. Typically, this requires switching equipment, using different flow paths and mixing devices, and essentially re-developing and re-validating everything that has been painstakingly done so far. With Sunbather, the transition to GMP can be done easily thanks to its recording features, interchangeable flow paths, and easily transferable design. Sunbather uses the same mixing process and protocols as the Sunscreen and Sunshine from the same Sun series, allowing for easy transition of adjusted formulation conditions to GMP. - Up to 1.8 L/h - Integrated inline dilution - Fully interchangeable flow paths - A wide variety of mixing devices - Software compliant with 21 CFR Part 11 - Process transferable from Sunshine

• Other Physics and Chemistry Equipment

Quality assessment of proteins, nucleic acids, AAV, LNP, etc. is possible with trace amounts and high throughput.

"Stunner" is a product that allows simultaneous acquisition of UV/Vis concentration, dynamic light scattering (DLS), and static light scattering (SLS) data from a 2μL identical sample. It enables detailed investigation of AAV and adenoviruses to measure total capsid titer and Empty/Full ratios, as well as to obtain payload concentration and size data of lipid nanoparticles all at once. You can analyze concentration, hydrodynamic size, polydispersity, and the presence of aggregates collectively, allowing you to assess the quality of proteins. This way, you can immediately determine whether your AAV, adenoviruses, lipid nanoparticles, or proteins are suitable for your purposes. [Features] ■ Measure up to 96 samples in a batch in 60 minutes*/12 minutes** *When measured by DLS **When measured by UV/Vis only [Applications] ■ AAV/Adenovirus capsid titer ■ AAV/Adenovirus Empty/Full ratio ■ Lipid nanoparticle (LNP) payload amount ■ Aggregate measurement ■ Concentration measurement ■ Sizing & polydispersity ■ B22 & kD *For more details, please refer to the PDF document or feel free to contact us.

• Other protein analysis

Up to 8 samples can be processed simultaneously! Automatic and hassle-free buffer exchange and concentration that used to be complicated!

Buffer exchange and concentration must be performed as a sample preprocessing step. This is a labor-intensive task that takes a long time, requiring your presence throughout the process. "UNAGI" is a fully hands-free benchtop buffer exchange solution designed to take over this tedious task. It can process up to 8 samples simultaneously. The software is very easy to operate, allowing you to be anywhere during the work, eliminating the need to stay in the laboratory the entire time. 【Features】 ■ Simultaneous processing of up to 8 samples ■ Efficient solvent removal prevents sample adsorption, achieving over 96% recovery rate ■ Built-in recipes for UF/DF buffer exchange ■ User-friendly software ■ Concentrates up to 8 diluted samples from 48mL to 8mL in one go *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research Software
• DNA analysis

[Video Available] Are you spending a lot of time and effort on buffer exchange and concentration work? You can streamline the sample preprocessing steps with this device.

Buffer exchange and concentration must be performed as a pre-treatment of the sample, which is a time-consuming task. This process takes a long time, and you have to be present the entire time. "UNAGI" is a fully hands-free benchtop buffer exchange solution designed to perform this tedious task for you. You can be anywhere during the process, eliminating the need to stay in the laboratory the whole time. 【Features】 ■ Simultaneous processing of up to 8 samples ■ Efficient solvent removal to prevent sample adsorption, achieving over 96% recovery rate ■ Built-in recipes for UF/DF buffer exchange ■ User-friendly software ■ Concentration of up to 8 diluted samples from 48mL to 8mL in one go *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research Software
• Other filtration and separation equipment

Introducing the details of the newly launched LNP production and screening device.

Researchers of lipid nanoparticles (LNPs) spend a tremendous amount of time on screening, optimization, and scaling up experiments to achieve optimal performance, spot-on targeting, and controlled release of active pharmaceutical ingredients (APIs). Factors such as solubility, pH stability, payload release, and encapsulation all depend on particle size, shape, and structure. In other words, to obtain the right formulation, it is necessary to explore a vast number of formulation parameters and process parameters one by one, and even if a perfect formulation is found, scaling up usually means switching equipment and re-optimizing settings. In this webinar, we will introduce a platform, Sunny Suite, that can reduce the time spent on these LNP formulations. ■ Date and Time: February 26 (Monday) 14:00~ ■ Speaker: Yuji Senoo, Field Application Scientist, Unchained Labs, Inc. ■ Register here: https://unchainedlabs.zoom.us/webinar/register/3217065146675/WN_U1o3xQoZRAKHN-A-7b1yqg

• Other protein analysis

It enables the monitoring of potency and purity throughout the entire workflow of lentivirus research and development, accelerating gene therapy development.

"Leprechaun" is a system that analyzes whether lentivirus particles are of the correct size and structure, and can measure viral titer. It allows for the determination of the titer of lentivirus present in a sample without being misled by confusing noise (such as incomplete viruses or contamination). Not only can it measure information that was previously only obtainable separately through conventional methods like ELISA, qPCR, and transduction assays, but it also enables structural analysis that those methods could not provide, all on a single platform. Capabilities: ■ Lentivirus titer ■ Lentivirus structure ■ Exosome concentration ■ Analysis of contamination (impurities such as extracellular vesicles) Features: ■ No sample purification required ■ Physical structural analysis possible ■ Distinction between virus integrity and impurities ■ Up to 16 samples can be measured at once *For more details, please refer to the PDF document or feel free to contact us.

• Other measurement and measuring equipment

[Speaker] Ministry of Land, Infrastructure, Transport and Tourism, Road Bureau, Planning Division, Road Economic Research Office Planning Specialist Yuki Endo [Key Lecture Content] The Ministry of Land, Infrastructure, Transport and Tourism is advancing discussions on the realization of automated logistics roads as a new form of logistics in response to recommendations from the "Interim Summary on the State of High-Standard Road Networks," addressing logistics crises and carbon neutrality. This lecture will introduce the final summary on the state of automated logistics roads published in July of the 7th year of Reiwa, as well as the demonstration experiments planned for the 7th year of Reiwa. [Lecture Items] 1. Final summary on automated logistics roads 2. Demonstration experiments for the 7th year of Reiwa 3. Q&A / Business card exchange

[Speaker] NTT Docomo Business Inc. 5G & IoT Services Department Director in charge of Global Connected Cars, Yuji Tamai [Key Lecture Content] The value of SDV lies in continuously cycling 'updates × data × cloud', and connectivity is a prerequisite for this. In this presentation, we will organize the barriers of quality, cost, and regulation faced in global expansion, and explain the design principles and operational models from roaming enhancement, eSIM/RSP (SGP.32), integrated management (CMP), NTN, to Network API. Additionally, we will delve into security aspects related to connectivity, introducing phenomena observed in actual service operations and their countermeasures, as well as exploring other operational updates (staged delivery, avoiding simultaneous activation, monitoring/observability). [Lecture Items] 1. Positioning of connectivity in SDV 2. Barriers to global connectivity 3. Designing to "strengthen" roaming 4. eSIM/RSP and SGP.32 5. Integrated connectivity management (CMP) and operations 6. Further connectivity - NTN and Network API 7. Security and update operations 8. Q&A

"Even though I'm communicating, nothing changes." "When I give a warning, the atmosphere gets worse." — Are you trying to solve these problems just by changing how you interact? What you need is not to move people, but to create a workplace that is easy to navigate. I will explain based on numerous examples of on-site improvements that I have supported. Held on May 27 (Wednesday). Please check the LP for more details. ▼ For more information and registration (free), see below.

At the Dry Fog Humidification System Free Demo Experience, you will have the opportunity to actually experience our Dry Fog, as well as our single-fluid and dual-fluid humidifiers. We will explain the differences from conventional humidifiers and the effects of implementation. In addition to introducing the latest case studies, we will also provide time for you to consult directly with our specialized staff. Please select a convenient venue and date from the application page and apply. * The "morning session" and "afternoon session" contain the same content. Please participate at a time that suits you. * This event is intended for users only. Participation from trading companies, other companies in the same industry, or for sales purposes to our company is not permitted. Venues: ■ Yamagata Venue: 3/12 (Wed) at Yamagata International Exchange Plaza 3/13 (Thu) at Sakata Chamber of Commerce and Industry ■ Sendai Venue: 3/14 (Fri) at Kiri no Ikeuchi Sendai Branch ■ Tokyo Venue & Osaka Venue: 3/18 (Tue), 3/19 (Wed), 3/21 (Fri) at Kiri no Ikeuchi Tokyo Sales Office & Kiri no Ikeuchi Osaka Headquarters ■ Nagoya Venue & Fukuoka Venue: 4/9 (Wed), 4/10 (Thu), 4/11 (Fri) at Kiri no Ikeuchi Nagoya Sales Office & Kiri no Ikeuchi Fukuoka Sales Office

In recent years, as many companies are considering modernization, exploring methods for system renewal has become an important issue. This seminar will focus on "Rewrite," one of the solutions to such challenges, and will explain questions and issues encountered during project promotion in a Q&A format. <Program> - Opening - How to advance system renewal through "Rewrite" and key points for problem-solving - Introduction of unique tools to support migration <Recommended for> - Those who are struggling with specific methods for system renewal - Those who are concerned about the continuity of maintenance for existing systems and a shortage of personnel - Companies that own IBM i (AS/400) *We may refuse applications from competing companies or those not eligible to participate.